This is a very interesting study using combinations of:Silymarin+ Ginkgo+ vitamin E+ propolis+ bilberry+ topical diclofenac + pentoxifylline injections. They had 5 groups using one or more of the above. The results were very significant!
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530853/
That is a big result and the actual treatment would not be hard to follow, except for the pentox injections.
Diclofenac gel/spray is just Voltaren.
I've very interested in this. I'm tempted to rush out and buy as many of the supplements used, but I'm wary. When I realized I was losing my hair I tried supplements and creams galore. Saw palmetto and propecia may have contributed to my peyronies. It certainly decreased my night time erections, and we all know we need healthy blood flow in the penis to prevent peryonies.
Anyway, I'm interested in hearing from anyone on this board who has tried silymarin, ginko biloba, propolis, bilberry, and/or any combination of them.
Nice study. Anyone here have experience using topical diclofenac / Voltaren?
Yes I tried it during the active phase for pain control and it seemed to reduce the pain by about 50 percent. I used the strong formulation which is 2.3 percent.
I called the pharmacist who indicated there is both a 1% and 3% Diclofec gel. I'm trying the 3%, will increase by 25% to match the 4% gel in the study and report back with any progress. I have also ordered the antioxidants used in the study.
Good luck mate!
Some improvement in one moth Tsanchez?
James
No, maybe worsening...I'm waiting to see Dr Lue on 10/20/17 and hoping to start xiaflex with the supplements.
Thanks for the update Tsanchez
I am not surprised it didn't help.
From reading all the posts on the forum for many years, very rarely I read about some topical treatment that helped with Peyronies
James
Has anyone heard of the PTX100 injections? Is thus pentox and is it injected into the plaque?
would you apply the voltaren/diclofenac on the shaft or on the glans where it gets absorbed more readily?
I've been applying on the shaft, especially at plaque
how would it ever penetrate to the plaque? the skin moves, it's like a glove on top. At least for an uncut penis like mine... I'm confused, maybe circumcised penises have a better chance of success from topical treatments?
I'm not sure, but the study had better results w the cream than w/o
Topical treatments IMO don't go deep enough, as pey ron has said the skin is like a glove, I am uncut also :-\
I believe it relates to the molecular weight of the topical.
Quote from: Tsanchez12369 on October 10, 2017, 09:48:03 PM
Has anyone heard of the PTX100 injections? Is thus pentox and is it injected into the plaque?
I have those, I follow the antioxidant therapy too.
I'm following the study but am substituting Xiaflex injections.
Quote from: Tsanchez12369 on October 11, 2017, 10:16:06 PM
I'm not sure, but the study had better results w the cream than w/o
We don't know that the cream had any effect in the study, since they added several oral supplements with it. They added propolis, for instance, which also has some positive peyronie's research on the books. Personally, I don't think topical NSAIDs will help at all.
True, but both inexpensive. I'm following the protocol but substituting Xiaflex. The article has a rationale for the diclofenac other than just pain relief.
Tsanchez12369: what's the purported rationale for dicloflenac?
"diclofenac has anti-inflammatory, analgesic, and antioxidant activity, but its antifibrotic activity has also been ascertained, as it has been shown to inhibit fibroblast proliferation.81–84"
How about taking it systemically as well, then?
It's a gel and mostly local to where applied. Can penetrate to deep tissues.
Diclofenac is an NSAID, as with all nonsteroidal anti-inflammatory drugs they should not be taken 'long term', mostly a heart risk. Having said that please update if any member gets an improvement with it :-\