Peyronies Society Forums

Special Boards => Resource Library => Topic started by: NeoV on November 11, 2014, 04:07:05 AM

Title: Acetyl-L-Carnitine Studies
Post by: NeoV on November 11, 2014, 04:07:05 AM
All relevant Acetyl-L-Carnitine (ALCAR) and Carnitine studies should be added here.

discussion of these studies HERE (https://www.peyroniesforum.net/index.php?topic=5648.msg62174#msg62174)

Directly related to Peyronie's
2007 - Comparison of vitamin E and propionyl-L-carnitine, separately or in... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/17706714) (Not effective)
2002 - Oral propionyl-l-carnitine and intraplaque verapamil in the therapy... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/12010235) (propionyl-l-carnitine)
2001 - Acetyl-L-carnitine vs tamoxifen in the oral therapy of Peyronie's d... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/11446848)

Testosterone & erectile dysfunction
2005 - Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of s... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/16286128)
2004 - Preliminary observations on the use of propionyl-L-carnitine in com... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/15383186)
2004 - Carnitine versus androgen administration in the treatment of sexual... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/15072869)

Vascular function and endothelial health
2015 - Oral L-carnitine supplementation increases trimethylamine-N-oxide, ... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/25636076)
2013 - Role of Carnitine Acetyl Transferase in Regulation of Nitric Oxide Signaling in Pulmonary Arterial Endothelial Cells (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565262/)
2012 - Does L-carnitine improve endothelial function in hemodialysis patients? (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634264/) (no effect)
2009 - Effect of Combined Treatment with Alpha Lipoic Acid and Acetyl-L-Carnitine on Vascular Function and Blood Pressure in Coronary Artery Disease Patients (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734271/) (positive effect)
2008 - Effects of carnitine supplementation on flow-mediated dilation and ... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/18993165?dopt=Abstract&holding=f1000,f1000m,isrctn)

Liver fibrosis & TGF-β
2014 - BMC Developmental Biology | Full text | TGF-ß1 induces senescence of bone marrow mesenchymal stem cells via increase of mitochondrial ROS production (http://www.biomedcentral.com/1471-213X/14/21) (needs analysis)
2014 - Protective effects of L-carnitine, N-acetylcysteine and genistein i... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/24239319)

Pain, nerves, & inflammation
2014 - The effects of N-acetyl-cysteine and acetyl-L-carnitine on neural s... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/24680856)
2014 - Prophylactic role of acetyl-l-carnitine on knee lesions and associa... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/24786526)
2014 - Acetyl-L-carnitine (ALCAR) for the prevention of chemotherapy-induc... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/25168296)
2009 - Neuroprotective effects of acetyl-L-carnitine on neuropathic pain a... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/18709658)
2007 - Double-blind, multicenter trial comparing acetyl l-carnitine with p... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/17543140)
2007 - Acetyl-L-carnitine in neuropathic pain: experimental data. - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/17696591)
2007 - Acetyl-L-carnitine for the treatment of chemotherapy-induced periph... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/17696592)
2006 - L-Acetylcarnitine: A Proposed Therapeutic Agent for Painful Peripheral Neuropathies (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430690/)
2005 - Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/15616239)
2002 - L-Acetylcarnitine induces analgesia by selectively up-regulating mG... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/11961116)

Carnitine deficiency
2012 - Carnitine Deficiency in OCTN2−/− Newborn Mice Leads to a Severe Gut and Immune Phenotype with Widespread Atrophy, Apoptosis and a Pro-Inflammatory Response (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480427/)

Other potentially helpful studies

Depression and neuroplasticity
2014 - A review of current evidence for acetyl-l-carnitine in the treatmen... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/24607292)
2013 - L-acetylcarnitine causes rapid antidepressant effects through the e... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/23382250)
2013 - A placebo-controlled trial of acetyl-L-carnitine and α-lipoic acid ... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/23948785)
2011 - Acetyl-L-carnitine reduces depression and improves quality of life ... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/21443422)
Dopamine
2004 - Repeated acetyl-l-carnitine administration increases phospho-Thr34 ... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/15066157)
1992 - Acetyl-L-carnitine releases dopamine in rat corpus striatum: an in ... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/1397026)
1991 - Effect of acetyl-L-carnitine on the dopaminergic system in aging br... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/1839317)
Noradrenaline and serotonin 
2012 - Chronic acetyl-L-carnitine alters brain energy metabolism and incre... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/22549035)
Uric acid and free radical production
2004 - Acetyl-L-carnitine prevents total body hydroxyl free radical and ur... - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/15219812)