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Special Boards => Resource Library => Topic started by: NeoV on February 28, 2016, 04:49:18 PM

Title: Caffeine thread
Post by: NeoV on February 28, 2016, 04:49:18 PM
It turns out there are many studies on coffee or caffeine and fibrosis. It is a xanthine derivitive just like pentox, and appears to work the same way by inhibiting TGF-beta and Smad2.

TGf-beta and fibrosis
2016- Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ, and reduces established fibrosis in ex vivo precision-cut lung slices -- Tatler et al. -- Thorax (http://thorax.bmj.com/content/early/2016/02/24/thoraxjnl-2015-208215.long)
2014 - Caffeine prevents experimental liver fibrosis by blocking the expression of TGF-β. - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/23903851)
2008 - Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via  (http://www.ncbi.nlm.nih.gov/pubmed/18486259)
2009 - Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver  (http://www.ncbi.nlm.nih.gov/pubmed/19291178)
2009 - Less Smad2 is good for you! A scientific update on coffee's liver benefits - Gressner - 2009 - Hepatology - Wiley Online Library (http://onlinelibrary.wiley.com/doi/10.1002/hep.23097/pdf)
2009 - About coffee, cappuccino and connective tissue growth factor-Or how to protect your liver!? - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/21783975)
2008 - Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases. - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/18783549)

Penis and erection
2012 - Caffeine relaxes smooth muscle through actin depolymerization. - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/22683573)
2008 - Effect of caffeine on erectile function via up-regulating cavernous cyclic guanosine monophosphate in diabetic rats. - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/18421070)
2004 - Effect of caffeine on response of rabbit isolated corpus cavernosum to high K+ solution, noradrenaline and transmural electrical  (http://www.ncbi.nlm.nih.gov/pubmed/14756689)

Inflammation in general
2013 - Effects of caffeine on the inflammatory response induced by a 15-km run competition. - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/23299767)
2004 - http://ajcn.nutrition.org/content/80/4/862.full (http://ajcn.nutrition.org/content/80/4/862.full)
Title: Re: Caffeine (Coffee) thread
Post by: NeoV on October 08, 2016, 02:33:43 AM
New one on TGF-beta! Good one,

Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ, and reduces established fibrosis in ex vivo precision-cut lung slices -- Tatler et al. -- Thorax (http://thorax.bmj.com/content/early/2016/02/24/thoraxjnl-2015-208215.long)
Title: Re: Caffeine (Coffee) thread
Post by: james1947 on October 10, 2016, 02:55:22 AM
Thanks NeoV, my blood pressure is low, so I can continue sipping the many daily coffees  ;D
Seriously I didn't see any negative side effects from coffee, just positive.

James