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Author Topic: Plaques softened big time  (Read 842 times)

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Walleye

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Plaques softened big time
« on: February 14, 2018, 03:55:51 AM »

So I finally got to see a Urologist who specializes in Peyronies Disease and such. I asked to be put on the cancelation list for appointments, as my appointment was for late July. I got a call back that day and got an appointment the day after, today.
I’ve been taking Pentox 400x3 for just over 2 weeks, and took 10 mg Cialis 4 times for ED within that time. 2 days ago I noticed my plaques were suddenly very soft. The day before they were hard, like rock hard. They’ve been hard since they developed in Nov 2017. I was shocked by how suddenly it happened.
I’ve been taking 300-400 Vit E every other day, along with Vit D, Omega, 1 a day, and Calcium. I started taking verapamil 2 weeks ago for my recurrent heart arrhythmia. And knowing it’s used in other forms for Peyronies Disease, and even my Cluster headaches, I have multiple uses for it.

So Uro told me my scar is large, yet said it’s good my curve is slight. Told me to take a pic of errection and again before next appointment in 6 months for comparison. Wrote me a 5mg daily Cialis script and told me how the generic at Costco is WAY cheaper. Cost me $85 for a months worth. My regular pharmacy was $70 for 4 20mg pills, and their generics were like a buck or 2 cheaper.
Also got some Verapamil cream 8% for twice a day. He told me to forget about the pharmacies expiry date, and told me unless it crystallizes it’s good. Unfortunately it’s labeled ‘do not refridgerate’ On it, and I forgot it in the truck for 5 hours. Thankfully it was pretty mild today, and I remembered when I did.
I asked about traction and he slightly scoffed. My ESL40 is coming tomorrow though. He said most guys can’t wear them often enough and can get blisters. I’m thinking he’s referring to the more elaborate traction devises as uncomfortable.

Anyways, I’m glad I now have all the tools to use and I have a Dr who knows his Peyronies Disease. Soft plaques were a good sign, finally. Yet it didn’t really change my curve. If I had to guess I’d say my curve is 5° and I can easily straighten it, and it will stay straight predominantly.

I forgot to ask him about the change in my flaccid hang I’ve noticed. My penis hangs flaccid, lie it’s been twisted to my left, same direction of bend. I have no real idea why. Maybe the uneven weight has begun to effect things while flaccid.
Nooner else have that happen? It’s like it’s hanging to my left like usual, but now twists with the top or up side more facing to my left now.
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swiss

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Re: Plaques softened big time
« Reply #1 on: February 14, 2018, 11:50:54 AM »

Do you have arrithmia or palpitations? I have palps. Good to hear about your plaques!
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Tsanchez12369

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Re: Plaques softened big time
« Reply #2 on: February 14, 2018, 01:32:32 PM »

Amazing such dramatic progress.  Was the verapramil the change during that time period?
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Walleye

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Re: Plaques softened big time
« Reply #3 on: February 14, 2018, 03:55:10 PM »

I’ve had arrhythmia for almost 25 years now. I’ve had 4 ablations, the last one was on my ventricle and seemed to finally ‘cure’ it. Yet the past few weeks I’ve had some serious palipitation sessions. Every beat is a PAC or PVC, and one time my blood pressure dropped to 91 over 60. The only thing I was taking at the time this started was Vit E, which I suspected, yet now I’m sure it’s not the cause.

My guess is either the Pentox finally started doing its thing and softened the plaques, or the Cialis. Maybe both. The Urologist said Cialis is (likely / probably) more effective than Pentox. He said the oral Verapamil isn’t effective, yet one would presume it might have an effect. To me Verapamil in my blood, vs Verapamil on my skin, would make me think the pill would be effective.

I know Verapamil is given to Cluster headache patients at progressively higher doses. Yet they want an EKG after you increase from 120, or if you have issues. I had issues going up to 240, but nothing serious, and they told me to just stick to 120 till the cluster finished. Some people take it everyday as a preventative (proactive).

The point being that probably anyone can take Verapamil, under Dr supervision. I’m not suggesting anyone take it for Peyronies Disease alone, but at the same time perhaps it’s effective. Yet I would assume Drs would be very much aware of Verapamil oral regarding Peyronies Disease.

My pain has been off and on and pretty slight. Yet I did have pain while flaccid at times which I thought was odd. Yet no pain at all in the past 3-4 days.
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betterbend

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Re: Plaques softened big time
« Reply #4 on: February 14, 2018, 08:14:25 PM »

There can be a lot of reasons why topical verapamil, or injected verapamil is more effective than oral.  One possible reason is that Verapamil is highly protein bound meaning a lot of it stays in the blood stream and doesn't get into the extra vascular area.  Also topical use and injections into the area may reduce the amounts into the rest of the body thereby reducing side effects.  As you know it's a fairly potent drug and taking it orally to have a Peyronies effect also causes the other therapeutic effects of verapamil. 

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NeoV

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Re: Plaques softened big time
« Reply #5 on: February 15, 2018, 06:23:22 AM »

I have had arrhythmia and palpitations sine I was 17 or so. My father and grandfather have pacemakers and Peyronie's and neuropathy. This is due to hyperinsulinemia. Stop eating carbs, and your palps will be gone, and your Peyronie's! My opinion of course.

Paolo

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Re: Plaques softened big time
« Reply #6 on: February 15, 2018, 08:29:05 AM »

Dang Neo, I wasn't aware you suffer arrhythmia and palpitations, this with neuropathy and peyronie's!
I presume you take meds or do you have regular checkups, do you take beta-blockers?

A rare case study of a 55 Year old male who suffers now with Peyronie's disease and Dupuytren's after using beta blocker timolol.

https://www.ncbi.nlm.nih.gov/pubmed/29423783

Interesting.
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Walleye

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Re: Plaques softened big time
« Reply #7 on: February 15, 2018, 01:57:37 PM »

I have had arrhythmia and palpitations sine I was 17 or so. My father and grandfather have pacemakers and Peyronie's and neuropathy. This is due to hyperinsulinemia. Stop eating carbs, and your palps will be gone, and your Peyronie's! My opinion of course.

Wow, fascinating. I was recently put on Metformin and started cutting carbs. I lost 25 pounds in 3 months but my diet has been not great the past month. I was right on the threshold for type 2 and have been prediabetic for quite a while. I thought I knew pretty much everything on a basic level regarding diabetes and metabolic functions. hyperinsulinemia is a new one for me and sounds like I may very well be effected by it.

Regarding the Arrythmia, is your SVT? Had an ablation? After 3 ablations I kept getting arrhythmia and I became the topic of a conference where it was proposed my re-entry was ventricular. Learning I’ve lived with V-tach for decades was concerning. The ablation for that wasn’t much fun and a whole level above an atrial ablation. Yet it’s been around 5 years and no arrythmia. Yet I’m not sure if what I’ve been having recently is considered tachycardia / arrythmia, since it’s not fast enough. Nor slow enough for brachycardia, but constant palps is likely a sign something is up.

Possibly it’s my pacemaker in the mail, sort to speak. Sometimes I think I’d rather have one and not have as much anxiety about a heart attack or nasty V-tach one day. I’m not sure how the eligibility and such work where you live, but I’d think you should / should of had an EP study done already. Perhaps you have and your condition is easily managed. At my worst I was in the ER once a week or 2 getting electrocardioverted, since nothing else worked. I could probably do it myself by now, and the nurses are usually pretty impressed with my knowledge and calmness. I sometimes refresh the Drs knowledge on the issue, lol.
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swiss

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Re: Plaques softened big time
« Reply #8 on: April 18, 2018, 02:24:08 AM »

I have had a lot of palps in the not so distant past. Mostly stress related, but I drastically increased my intake of oral magnesium.
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pey ron

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Re: Plaques softened big time
« Reply #9 on: April 18, 2018, 10:16:19 AM »

told me how the generic at Costco is WAY cheaper

I guess there's a generic in Canada but there's no generic in the US, right? I believe the same will run for about 400 dollars a month in the US.
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