Tamoxifen?

[James9876]

Hello,

I've just been prescribed Tamoxifen by my doctor.  Has anybody here had any experience of this drug?

Thanks,

James

[Paolo]

I thought it was to block hormones, look up SERM?

Be careful.

[NeoV]

I dont' recommend it. Acetyl-L-Carnitine did better than it in one study.

[Old Man]

Hey All:

This drug is usually prescribed for women in therapy/treatment for breast cancer. It will change the hormone balance in men, so I see no reason for Peyronies Disease therapy. Who knows??

Anyway, maybe there is a ''new'' drug for Peyronies Disease.

Old Man

[James9876]

There have been a few studies with mixed results.  

https://www.ncbi.nlm.nih.gov/pubmed/1486392

https://www.ncbi.nlm.nih.gov/pubmed/10569556

i'll give it a go for a few months though, maybe it could help.

[popopo]

I don't have experience wih Nolvadex (tamoxifen), but I do have experience using clomiphene which does basically the same thing in the body. It's nit worh the side effects in my opinion. Clomid gave me permanent floaters and visual side effects are common in both nolva and clomid as well as emotional side effects like depression. It does raise your testosterone while using it, but you won't feel any of ot because the substance has "estrogenic" side effects as well.. all in all not an option. I am however interested in what Aromasin could to for testosterone levels. In theory blocking (too much) estrogen conversion would increase testosterone, especially free testosterone. There are also studies done that confirm aromasin raises test, but the problem is you can easily drive your estrogen too low which can lead to even more problems than low testosterone (bone loss, depression, sore joints) and it's hard to measure how high/low estrogen levels are exactly. In short, no use for peyronies. In theory clomid and nolva raises test and estrogen, while aromatase inhibitors like aromasin raise test and lower estrogen. I wouldn't use any of these substances unless you're on steroids, but in very specific cases where estrogen is high and testosterone is low/low-average an aromatase inhibitor like aromasin could help.

[James9876]

My Doc explained that the Tamoxifen could help to reduce inflammation and therefore pain and reduce fibrosis but he didn't mention testosterone levels as a way to treat Peyronies.  The first bit of the below gives a brief explanation of how it supposed to work.

https://prostate.net/articles/can-tamoxifen-treat-peyronies-disease

I've been on it a couple of days now with no obvious effects at all so far.  But I'll update if I see any improvement.

[popopo]

Tamoxifen raises testosterone levels by binding to the estrogen receptor in your hypothalamus. As a result your body "thinks" it lacks estrogen so it produces more LH and FSH and in turn your hormone levels are gonna rise for as long as you take it. The reason I know this is because it's commonly used by bodybuilders after a cycle. I did read that it used to be an option for peyronie's as well, but never heard any true succes stories and the side effects can be bad especially on mood and vision. I think for peyronies pentoxifilyne, cialis and even acetyl l carnitine are better options with fewer side effects.

[James9876]

Interesting, I don't feel anymore masculine than I did a few days ago but we'll see what happens.

My problem is a bit of an odd one as I'm not sure I have Peyronies but as my doc doesn't have a good explanation as to whats happening to me he suggested we treat it as such.  

I've had pain and atrophy mainly on the right hand side of my dick which has been happening for the last 3-4 years or so.  My penis almost seems to be slowly wasting away, although it still all works ok at least for the moment.  i've had a dopler ultrasound and MRI that identified a very small plaque (fibrosis) at the base of my penis somewhere near where the pain is located.  but I only have a slight bend to the right and still can have sex although it is a bit painful on occasions.  

I think my doc suggested the Tamoxifen as really a pacification as he realized I wanted something to be done.  I don't think that it will help if I am honest but will give it a go.  

Interestingly when I had the dopler ultrasound it identified that the blood flow was half as strong on the side of my penis that has the atrophy.  Although it was within accepted normal limits but it suggest to me that i have some sort of blood flow issue.  Maybe pentox might help me more as i know that is associated with improving circulation.