Peyronies Society Forums

Please login or register.

Login with username, password and session length
Advanced search  

News:

Augusta Med System info for Australians
Link to post

Pages: [1]   Go Down

Author Topic: Why doesn't a topical Pentox Cream Exist? That Seems Like It Would Be Perfect  (Read 1415 times)

0 Members and 1 Guest are viewing this topic.

maxster

  • Voting Member
  • **
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 9

So I believe pentox can certainly help in combination with other treatments, but let's be honest, when you take an oral medication it gets dispersed all throughout the body. With that said, why do you guys think a topical pentox cream has not yet been made. If it does, I certainly have not found it.

The molecular weight of pentox is 278.31 g/mol, which is well under the 500 rule to pass through skin.

What do you guys think? Is there any way to compound a cream ourselves?
Logged

james1947

  • Major Contributor
  • ****
  • Country: ro
  • Offline Offline
  • Gender: Male
  • Posts: 6435
  • Age 70. Peyronies from January 2009

Have, I mean topical Pentox.
I suppose if you will invest time on a search on the forum you will find the topic

James
Logged

QuackAttack

  • Major Contributor
  • ****
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 510

Maxster,

Creams typically don't work because they won't penetrate deep enough. Many of us, me included, have done the DMSO combo route and found it to be ineffective. Xiaflex, however, when injected into the plaque breaks up the plaque from the inside of the plaque.
Logged

Paolo

  • Major Contributor
  • ****
  • Country: gb
  • Offline Offline
  • Gender: Male
  • Posts: 800
  • 56 Year old with stable Peyronie's

I have to agree, creams or gels seem ineffective, remember the hope of H-100 topical treatment, what happened??.................https://www.ncbi.nlm.nih.gov/pubmed/26700214

Nothing  :(
Logged
People who think they know everything are a great annoyance to those of us who do.

pey ron

  • Major Contributor
  • ****
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 361

@Paolo: dr Levine told me H-100 was very promising but they don't have H-100 available from any supplier... or something to that tune...
Logged

Tsanchez12369

  • Major Contributor
  • ****
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 1310

And there's the recent study w diclofenac
Logged

pey ron

  • Major Contributor
  • ****
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 361

And there's the recent study w diclofenac

it was linked below by Paolo. Then I mentioned that when I mentioned that study to dr Levine (one of the two authors!!!), dr Levine said that H-100 is no longer available...
Logged

Paolo

  • Major Contributor
  • ****
  • Country: gb
  • Offline Offline
  • Gender: Male
  • Posts: 800
  • 56 Year old with stable Peyronie's

I have at last received a courteous e-mail from Harold Hoium @ Hybrid Medical saying that to 'monitor the website for updates and suggest the same to your urologist'.
Logged
People who think they know everything are a great annoyance to those of us who do.

Christopher1

  • Major Contributor
  • ****
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 320

There is a doctor in Oregon who prescribes a compounded cream which consists of pentox, iodine, DMSO, verapamil, and vitamin E.

A member here posted about it. He got significant improvement out of the cream.
Logged
NEW MODALITY: Erectile Dysfunction and Peyronies Disease - Peyronies Society Forums
I highly recommend a high-fish diet for Peyronies Disease.

pey ron

  • Major Contributor
  • ****
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 361

Where does one find compounding pharmacies in the US?
Logged

Christopher1

  • Major Contributor
  • ****
  • Country: us
  • Offline Offline
  • Gender: Male
  • Posts: 320
Re: Why doesn't a topical Pentox Cream Exist? That Seems Like It Would Be Perfect
« Reply #10 on: September 30, 2017, 12:01:00 PM »

They are everywhere.

You just need a doctor to write what he wants in a cream.
Logged
NEW MODALITY: Erectile Dysfunction and Peyronies Disease - Peyronies Society Forums
I highly recommend a high-fish diet for Peyronies Disease.

PD

  • PDS Newbie
  • *
  • Country: gb
  • Offline Offline
  • Gender: Male
  • Posts: 1

With that said, why do you guys think a topical pentox cream has not yet been made. If it does, I certainly have not found it.

The molecular weight of pentox is 278.31 g/mol, which is well under the 500 rule to pass through skin.
What do you guys think? Is there any way to compound a cream ourselves?

The problem might be the other stuff that you get in a pentoxifylline tablet (or any other tablet designed for oral use).
For example, the Trental formulation of pentoxifylline contains benzyl alcohol, FD&C red no.3, hydroxyethyl cellulose, hydroxypropyl methylcellulose, magnesium stearate, polyethylene glycol 8000, povidone, talc, titanium dioxide.
All of that extra stuff might get through the skin also.
I don't know if it would it do any harm?
Do you guys know?


Logged

james1947

  • Major Contributor
  • ****
  • Country: ro
  • Offline Offline
  • Gender: Male
  • Posts: 6435
  • Age 70. Peyronies from January 2009

God point Peyronies Disease, but I don't have answer to your question.
I hope some forum members with better knowledge in medications will write the opinion.
Maybe a search on the web for those substances will give some answers, I am not enough knowledgeable to understand the answers.

James
Logged

projectpd

  • Voting Member
  • **
  • Country: gb
  • Offline Offline
  • Gender: Male
  • Posts: 23

what an interesting question.

I have no specific knowledge but googled the ingredients:

FD&C red no.3
just scrape off the coloured coating?
by the way is yours a bright pink colour with tendency to fade. just curious if mine is genuine.

hydroxymethyl cellulose
molecular weight is very high :
https://www.sigmaaldrich.com/catalog/product/aldrich/308633?lang=en&region=GB

hydroxypropyl methylcellulose  : weight is very high:
https://www.ncbi.nlm.nih.gov/pubmed/2394933

magnesium stearate
591.27 g/mol
https://en.wikipedia.org/wiki/Magnesium_stearate
 . within weight range but magnesium and stearate both natural from food?,

polyethylene glycol 8000
https://www.sigmaaldrich.com/catalog/product/sial/p5413?lang=en&region=GB
"average mol wt 8,000"
hence the name? dont know. this is antifreeze/
maybe small amount ok?

povidone
https://watermark.silverchair.com/49-6-457.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAawwggGoBgkqhkiG9w0BBwagggGZMIIBlQIBADCCAY4GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM_ah4TQkwY_leIBL3AgEQgIIBX4KXJf7LO9zVIW9udeBs1d9iCKf5mm2pcHe5-FP4lhqaGEqgGKq5h8P9o--jTDnrlGZ4zgpQ1zx3As4aR1s6AJhfMtcTPsVRV8_rSuc5BNb0SrSs1lRbgbEsxcxjk3VDOCkuYvD73opkrF4o4WD_lJ9PZkyF1uvESzHtoiuc_CPl0uP9ryHBXZ6Djk--0puHt8tniVdwqE86y9EDwjcgqtRlPfStkugzA4xX8Rv3k0ug9eOOitoKaYwowDvkHFQtAHoP2zeC254wW7ixhh4V7VFvMbtwkKCWpdVtH_NQE8tzuo-Z4XLuwXN0rVR8VS34nxLl4ojCJWcmR910ajmXuhcr7ijOjSc88BiaFNTH0u20UGEtTR95-4yhCfynAZhWRj_2ixlxFSxh3eE8ZYFcqSOzhqzJhHWqRf3F_oZW4X0L4UTypN7pv0wz3fSo9pjCjne3ZLVG8wn3Y-WUCwMNZQ

" A wide range of molecular weights, from a few thousand to a few million Daltons can be obtained by controlling the degree of polymerization "

talc
Talc Mineral Data
molecular weight 379g/m
assume this could well be absorbed.

I don't know, but maybe this could be worrying, obviously depending on the amount:
http://www.bluelight.org/vb/archive/index.php/t-525320.html
https://www.ncbi.nlm.nih.gov/pubmed/2198684
https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+830
https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+830

INTRAVENOUS INJECTION of talc-containing tablets or
          capsules produces foreign body vascular granulomatas
          (microemboli) at the site of intramuscular or
          subcutaneous injection and widespread arterial wall
          granulomas.
      4)  SYSTEMIC GRANULOMATOSIS has been reported in IV drug
          abusers. Angiothrombotic pulmonary arterial
          hypertension and cor pulmonale may develop. Mild
          retinal hemorrhage may occur following IV injection of
          talc or talc containing products. Pulmonary effects
          include nonproductive cough, fever, dyspnea, and
          granulomatosis. Subtle x-ray changes may develop
          showing symmetrical hilar and perihilar interstitial
          infiltrations which are only minimally reversible. As
          the disease progresses, typical findings on chest CT
          include large and irregular attenuated nodules
          ("ground glass") in the middle and upper part of the
          lung following intravenous abuse of oral drugs. These
          nodules can evolve into large masses or consolidations
          and panlobular emphysema can develop in the lower
          lobes likely following years of abuse.
      5)  OPEN WOUNDS: When talc is applied to open wounds or
          contaminates wounds during surgery, it can cause a
          severe granulomatous reaction. Talc should not be
          applied to broken skin. It is a severe eye irritant
          and has caused symblepharon, serious enough to require
          surgical correction



titanium dioxide
molecular weight 79.866 g/mol
assume this would be absorbed.
but, it is used as a colouring : if it is only in the coloured coating (to make it the bright pink rather than bright red), which you could scrape off





Logged
Pages: [1]   Go Up
 

Related Topics

  Subject / Started by Replies Last post
1 Replies
1109 Views
Last post July 24, 2016, 01:50:54 PM
by LWillisjr
8 Replies
426 Views
Last post March 16, 2018, 07:10:48 AM
by Tsanchez12369
4 Replies
499 Views
Last post April 09, 2018, 02:57:42 AM
by Paolo