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Author Topic: Diabetes of the Penis: Peyronie's and Diet  (Read 13879 times)

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Gabriel

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #100 on: April 14, 2019, 03:49:56 AM »

Fascinating phenomenon, thanks man.

That's another info supporting fasting... Which, by the way, is considered quite safe even by hard science: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819235/
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- 31 yo, very healthy lifestyle, Peyronies Disease with Erectile Dysfunction, pain, distal hourglassing & length loss since 09/01/17, still acute.
- Treatments: all oral meds/supps discussed here; traction/VED; ointments (essential oils, diclofenac); PRP/HA injections (5/6 sessions)

TonySa

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #101 on: April 14, 2019, 05:49:42 AM »

Interesting article.
Of note, fasts one greater than one day (less than one day = IF) were medically supervised twice per day.  Any fasts were discontinued if problems arose (noted by patient or MD).
Also, it sounds as if all meds were d/c’d except thyroid meds tittated appropriately.
I believe this is why extended water fasting is recommended to be done under a doctors care and includes bloodwork to screen for appropriateness (as all were in this study)
Good news, intermittent fasting seems pretty straightforward without needing medical clearing or monitoring throughout as does dctrnded water fasting.
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Gabriel

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #102 on: April 14, 2019, 08:11:46 AM »

Very good point Tony!

It's pretty clear that if you are know as diabetic or fragile in this or that metabolic field, you shouldn't fast without medical precaution; that's common sense. But for anyone said to be healthy (apart from Peyronies Disease of course...), or, better said, without specific syndroms, I do believe fasting alone can be totally safe as long as you investigate it first and get well prepared (with mineral water + electrolytes, an activity planning, good food to break your fast anytime you fell like it, etc.).

That is pure theory from now, as I've just made one 3 days fast so far (everything OK); I'm beginning a 7-10 one from tomorrow, I'll let you know what comes out of it :-)
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- 31 yo, very healthy lifestyle, Peyronies Disease with Erectile Dysfunction, pain, distal hourglassing & length loss since 09/01/17, still acute.
- Treatments: all oral meds/supps discussed here; traction/VED; ointments (essential oils, diclofenac); PRP/HA injections (5/6 sessions)

NeoV

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #103 on: April 14, 2019, 09:13:03 AM »

Thank you whyisthishappening,

No surprise but very useful find!
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skunkworks

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #104 on: April 14, 2019, 12:31:35 PM »

Totally random thought, but it's kinda like the penis is the canary in the coalmine. First thing to show the hurt when things get too toxic.

TonySa

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #105 on: April 14, 2019, 11:00:29 PM »

Personally, even if healthy (could be underlying issues one was Unaware) I’d go no longer than 7 days without medical supervision.
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Whyisthishappening

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #106 on: April 15, 2019, 12:20:33 PM »

L-cysteine supplementation upregulates glutathione (GSH) and vitamin D binding protein (VDBP) in hepatocytes cultured in high glucose and in vivo in liver, and increases blood levels of GSH, VDBP, and 25-hydroxy-vitamin D in Zucker diabetic fatty rats.
https://www.ncbi.nlm.nih.gov/pubmed/26778482
L-Cysteine Supplementation Increases Blood Levels of Hydrogen Sulfide and Nitrite, and Decreases Insulin Resistance and Vascular Inflammation in Zucker Diabetic Rats
https://professional.diabetes.org/abstract/l-cysteine-supplementation-increases-blood-levels-hydrogen-sulfide-and-nitrite-and
Can L-Cysteine and Vitamin D Rescue Vitamin D and Vitamin D Binding Protein Levels in Blood Plasma of African American Type 2 Diabetic Patients?
https://www.ncbi.nlm.nih.gov/pubmed/25816831
 guys what do you think about l-cysteine
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pey ron

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #107 on: April 17, 2019, 01:43:40 AM »

i think both hydrogen sulfide & nitrite are gonna help a lot, so i am gonna get on L-cysteine soon!
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Whyisthishappening

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #108 on: April 17, 2019, 08:59:19 AM »

ron DO NOT try L-CYSTEINE i can elaborate later not now

  this disease is Not us simple as we try to understand it
 
   i am focusing now on WNT2 PROSTAGLANDINS and prostaglandin receptor abnormalities(thats why some got Peyronies Disease after alprostadil although its antinflammantory(PGE1)  prostaglandin receptors with abnormalities could give signal as it is PGE2 a pro inflammantory and start inflammation cascade ) also HEPARINASE 1 and 2 should have our attention also i am making a link why   thc and cbd are bad for us even if for many is antiinflammantory
       
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Whyisthishappening

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #109 on: April 17, 2019, 04:15:45 PM »

Structural and dynamic characterization of human Wnt2-Fzd7 complex using computational approaches.
https://www.ncbi.nlm.nih.gov/pubmed/30191337
  "Wnt and Frizzled (Fzd) family members play crucial roles in the self-renewal of tumor-initiating cells. Until now, only a few studies have addressed the distinct mechanism of Wnt-Fzd interactions. In this study, we suggest a possible interaction mode of Wnt2 with the Fzd7 CYSTEINE-rich domain (CRD)-both of which are up-regulated in some types of cancer"
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TonySa

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #110 on: April 17, 2019, 11:09:16 PM »

If same effect, how is it a “cheat”?
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pey ron

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #111 on: April 18, 2019, 12:11:53 AM »

NAC is a very powerful antioxidant.

I believe PGE2 would be anti-fibrotic. And I wonder if PGD2 wouldn't be profibrotic.

WNT is scary as hell, I believe it is proliferative and profibrotic. Well, I believe PGE2 is proliferative as well but oddly antifibrotic.

I also believe that some PPAR's can be strong antifibrotics despite being proliferative.

I would love if someone were able to get to the bottom of these.

Profibrotic = inducing fibrosis
Proliferative = making cancers grow
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Whyisthishappening

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #112 on: April 18, 2019, 06:18:21 AM »

no man pge2 is pro inflammantory (prolonged inflammation=fibrotic cascade )

"If same effect, how is it a “cheat”?"      tony i do not understand  please explain
 
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pey ron

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #113 on: April 18, 2019, 01:07:47 PM »

why are you making statements in the present indicative about PGE2 being pro-fibrotic?

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Whyisthishappening

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #114 on: April 18, 2019, 03:00:32 PM »

it is proinflammantory  and prolonged inflammation in tunica albuginea is bad
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Whyisthishappening

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #115 on: April 18, 2019, 03:05:42 PM »

Molecular Mechanisms Underlying the Link between Diet and DNA Methylation
https://www.mdpi.com/1422-0067/19/12/4055/htm
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pey ron

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #116 on: April 18, 2019, 04:50:01 PM »

Prostaglandins are not as easy as that: they also resolve inflammation. PGE2 has an extremely short half-life, in the order of minutes. And not all PG's are born equal. There are several pathways and sometimes a given PG can extert both an anti-fibrotic and a pro-fibrotic effect, depending on the receptor it docks to. For example PGD2 is pro-fibrotic when it docks to the CRTH2 receptor, but anti-fibrotic when it docks to the DP1 receptor. So, blocking the CRTH2 receptor via setipiprant/fevipiprant would be ideal. Dig deeper, keep an open mind.
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Whyisthishappening

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #117 on: April 18, 2019, 05:29:19 PM »

i keep an open eye also
  Penile fibrosis in intracavernosal prostaglandin E1 injection therapy for erectile dysfunction.
https://www.ncbi.nlm.nih.gov/pubmed/9442421
"Penile fibrosis is hence a significant complication of intracavernosal PGE1 therapy"
The long-term safety of alprostadil (prostaglandin-E1) in patients with erectile dysfunction. The European Alprostadil Study Group.
https://www.ncbi.nlm.nih.gov/pubmed/9806184
"Penile fibrosis occurred in 4% of patients"
CAVERJECT IMPULSE®(alprostadil) for injection, for intracavernosaluse Initial U.S. Approval: 1981
http://labeling.pfizer.com/ShowLabeling.aspx?id=667&format=PDF
CONTRAINDICATIONS
"• Treatment of erectile dysfunction in men with fibrotic conditions of the
penis, such as anatomical deformation, angulation, cavernosal fibrosis, or
Peyronie’s disease (4)"
Peyronie's-like plaque after penile injection of prostaglandin E1.
https://www.ncbi.nlm.nih.gov/pubmed/8051767
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pey ron

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #118 on: April 19, 2019, 02:10:16 AM »

1) the needle causes trauma every single time it pierces the tunica
2) PGE1 is not PGE2... PGE1 belongs to the family 1 of prostaglandins, PGE2 to the family 2 of prostaglandins. Most humans have predominantly PG's from the family 2 -- with the sole exception of Eskimos that due to their diets very rich in different kinds of fatty acids have a completely different proportion of ecosanoids.
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Whyisthishappening

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #119 on: April 19, 2019, 06:16:02 AM »

it is not only the needle enthourethral alprostadil is prohibeted also, check the instructions. we can make a thread about prostaglandins or erection injections lots of people here ad them and i think we hijack this thread

  because this is about dibetes of the penis
  in cadavid 2015 igf increases the most after tgf stimulation in plaque ,that is in active Peyronies Disease phase what you want to avoidthe most besides another injury is insulin spikes neos hypothesis is solid
 
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Whyisthishappening

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #120 on: April 19, 2019, 10:00:42 AM »

The effect of Ferula elaeochytris root extract on erectile dysfunction in streptozotocin-induced diabetic rat.
https://www.ncbi.nlm.nih.gov/pubmed/30979969

" FE recovered neurogenic and endothelial dysfunction and decreased glucose levels in diabetic rats."
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pey ron

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #121 on: April 19, 2019, 09:23:46 PM »

yes this thread should have been split off a few posts ago...
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Gabriel

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #122 on: April 22, 2019, 12:18:59 PM »

An excellent and pedagogical resumen of the ubiquitous influence of insulin resistance and the benefits of keto/IF about the multiplicity of pathologies involved: https://www.youtube.com/watch?v=tRPqYqa3oLA (title is obviously ironical!)
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- 31 yo, very healthy lifestyle, Peyronies Disease with Erectile Dysfunction, pain, distal hourglassing & length loss since 09/01/17, still acute.
- Treatments: all oral meds/supps discussed here; traction/VED; ointments (essential oils, diclofenac); PRP/HA injections (5/6 sessions)

Whyisthishappening

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #123 on: April 23, 2019, 05:53:48 AM »

The negative effect of the adverse systemic milieu on adult stem cells.

https://www.researchgate.net/project/The-negative-effect-of-the-adverse-systemic-milieu-on-adult-stem-cells

Goal: Autologous adult stem cell transplantation is frequently unsuccessful in repairing the targeted problem. Our results suggest that the toxic systemic environment, i.e. hyperglycemia or hyperlipidemia is impairing the repair capacity of adult stem cells via epigenetic modifications. The goal of this study to clarify the underlying mechanisms and determine new biomarkers that can predict stem cell damage before transplantation
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Whyisthishappening

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #124 on: April 23, 2019, 08:59:59 AM »

Original Article Effects of hypercholesterolemic diet by long-term on elastic system fibers penile tissue: volumetric density analysis of elastic system fibers
https://www.researchgate.net/publication/303475300_Original_Article_Effects_of_hypercholesterolemic_diet_by_long-term_on_elastic_system_fibers_penile_tissue_volumetric_density_analysis_of_elastic_system_fibers
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Whyisthishappening

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #125 on: April 23, 2019, 05:24:30 PM »

check this FQ and DM
Can antibiotics cause, or make Peyronies Disease worse? - Peyronies Society Forums

Acute metabolic amplification of insulin secretion in mouse islets is mediated by mitochondrial export of metabolites, but not by mitochondrial energy generation
https://www.sciencedirect.com/science/article/pii/S0026049513001479

Defining and characterizing the critical transition state prior to the type 2 diabetes disease
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180937

Multiple Biomarker Prediction of Type 2 Diabetes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699735/

Identification of Biomarkers for Type 2 Diabetes and Its Complications: A Bioinformatic Approach
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614656/

Biomarkers for predicting type 2 diabetes development—Can metabolomics improve on existing biomarkers?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503163/

Predictive biomarkers for type 2 of diabetes mellitus: Bridging the gap between systems research and personalized medicine
https://www.sciencedirect.com/science/article/pii/S187439191830099X



Study of Protein Biomarkers of DIABETES Mellitus Type 2 and THERAPY with VITAMIN B1
https://www.hindawi.com/journals/jdr/2015/150176/
 
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Christopher1

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Re: Diabetes of the Penis: Peyronie's and Diet
« Reply #126 on: April 24, 2019, 08:06:00 PM »

My Peyronies Disease was caused by Trimix injections. So...
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