I mentioned a study
here relating to the potential use of Superoxide Dismutase in the treatment of peyronie's (as well as other instances of fibrosis). Unfortunately the "topical gel containing liposomally encapsulated recombinant human superoxide dismutase" mentioned isn't available to purchase. Not that we know that it would work, but any positive peyronie's study is worth exploring.
Superoxide Dismutase is available from iherb in the forum of a dietary supplement called S.O.D.
I just now found what is claimed to be an enhanced verison of Superoxide Dismutase from 'Life Extension' called
GliSODin. It contains cocoa and pomegranate too. (
wikipedia page)
Taurine may be a useful addition to the peyronie's arsenal, and it does appear that taurine raises superoxide dismutase levels, so maybe it is useful in part due to this mechanism:
Effect of taurine on alcoholic liver disease in rats.
Wu G, Yang J, Sun C, Luan X, Shi J, Hu J.
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
gaofengwu@126.comTo investigate the effect of taurine on alcoholic liver disease in rats, male Wistar rats were administered alcohol intragastrically for 3 months. The effect of beta-alanine-mediated taurine depletion and taurine administration on the development of alcoholic liver disease was examined. It was found that taurine administration produced lower levels of aspartate aminotransferase and alkaline aminotransferase than that of the untreated group. In addition, the levels of hepatic total protein, glutathione and
superoxide dismutase were higher in the taurine treated groups than in the untreated control or the taurine depleted group, while hepatic malondialdehyde content exhibited the opposite effect. Moreover, the content of hepatic hydroxyproline, serum hyaluronic acid, interleukin-2, interleukin-6, tumor necrosis factor-alpha and laminin were all decreased in the taurine treated group. The pathological changes showed that the percentage of fatty degeneration and inflammation in the taurine group were less than that of the control, taurine depleted and automatic recovery groups. These in-vivo findings demonstrate that hepatic disease caused by chronic alcohol consumption can be prevented and reversed by administration of taurine.
In fact countless studies state that taurine increase SOD. Should anybody else ever be interested or able to go the hyperbaric chamber route oxidation, as a strange coincidence the wikipedia page references a study that shows that Glisodin
is helpful in protecting against DNA damage in such circumstances.
Four small studies are listed in
this pdf state that injectable Orgotein (which is superoxide dismutases) may show promise in peyronie's patients when injected, though some of the peyronie's disease summary studies elsewhere hint that it hasn't been consistently useful.
It appears that we aren't going to get hold of the injectable version of this anytime soon, but maybe the enhanced oral bioavailability version may be of use to us. Adding an oral version to a regime seems like a safe bet since it has anti inflammatory and anti fibrotic properties in a number of conditions. I'm aware that there are a fair amount of assumptions here, but that's true of any area we explore.
