I honestly think I have the worst case of Peyronie's disease ever.

[Michiganguy19]

I'm guessing most of your peyronies came from a single injury and you have a single large mass of scar tissue?

Has anyone gotten their peyronies from arthritis? I have reactive arthritis from a bacterial infection. Got arthritis from a chlamydia infection from hooking up with a stripper in fall 2015. I think it's cause I waited too long to go to docs when I got white discharge. We used a condom so for like 2 weeks I ignored the discharge and assumed it was precum from watching porn or my body flushing out old stuff. Didn't go to docs cause it didn't hurt that bad. But honeslty, chlamydia is really common. I haven't had it in a year and Reactive arthritis is suppose to go away in 8 weeks. Mines not. Makes me feel like something else is causing it. I have a sinus infection I can't get rid of. Think it's triggering it somehow. But my doc says ReA is sexual only. But my sinus is by the brain so maybe it's spreading. Idk. Just like my joints pop daily, so does my penis. Multiple tiny pops every few minutes. They sting a little but not bad. Before the urologist said it's probably just air bubbles. But I know now it's my connective tissue being damaged on a smaller scale, but constantly.

Does anyone else have constant little pops in the tissue of their penis? I have hard ridges that start at the base of my penis and go all the way up. I cannot get a full erection anymore without vigorously stroking it.  I don't even want to say what size my penis is flaccid now most days. Used to be 6in flaccid, and now it's tightened up to nothing most days. Literally. Embarrasing af. Erect it's still long, but my girth is completely gone.

And this damage is happening every day. I don't think it will ever stop as my reactive arthritis is permanent. It will just keep going until nothing's left. I've already been to special urologists who said we can try verapamil injections but they usually don't help much. Idk what to do besides end it. This just keeps getting worse and worse. I'm already on coq10, ALC, l arganine, yohimbe, msm and chondritton, none of this crap does anything.

Never going to get married. Never going to have kids. Idk what to do. Felt like I couldn't move to anyone new. Stayed clingy on that stripper. Just felt like I wasted my future on her. I'm not even sure my docs right though. Feel like something is much worse.

[Paolo]

Hi Michiganguy19, great to hear from you  

Google 5-LOX Inhibitor with regards to arthritis, might be worth considering.

I take it for joint pain  

Keep posting please

[dru92646]

Welcome Michiganguy19,
Try to hang in there.This is a tough thing to deal with emotionally when when you have a severe form of the disease and treatments are not helping you significantly.I too have lost significant length and girth.My curvature is so severe that intercourse is virtually impossible right now and I have always had a great sexual life.I too am a little lost and depressed. I am now having ED problems which I never had before.This may be do to my knowing now that I am limited in how I can satisfy my wife. Im no psycologist but I have lost a lot of confidence and emotionally this probably doesnt help ED.Lets agree that no matter how bad it gets try to be positive and look to future treatment modalities.I am trying new ways to give and receive sexual gratification.You may be surprised that a willing partner may try to help both of you get through this.Good Luck and find a good urologist to help you with the decision making processes.

[skunkworks]

Hi Michiganguy19, I have moved your thread to the general forum as intro threads are locked after 10 posts and you already have one of them anyway.

If I were you I would be pushing hard to get on sulfasalazine like yesterday. It is one of the recommended treatments for reactive arthritis and I personally believe there is a very good chance it could be a more effective treatment for Peyronie's than pentox.  

[Paolo]

Hi Michiganguy19, I have moved your thread to the general forum as intro threads are locked after 10 posts and you already have one of them anyway.

If I were you I would be pushing hard to get on sulfasalazine like yesterday. It is one of the recommended treatments for reactive arthritis and I personally believe there is a very good chance it could be a more effective treatment for Peyronie's than pentox.

Skunkworks, please elaborate on sulfasalazine being more effective than pentox  

I know it is used for Inflammatory bowel disease, also decreases sperm count  

[skunkworks]

I don't know that it is so I cannot elaborate on 'it being more effective' than pentox. It has certain features that lead me to the idea that it has the potential to be more effective.

An earlier post by me on this forum about it:

There may be more to it than that.

These Myofibroblast - Wikipedia, the free encyclopedia are essentially what causes permanent fibrosis as they secrete a protein which prevents the fibrosis from being broken down. When the myofibroblasts fail to undergo apoptosis (die) as they should then you are stuck with the fibrosis. Myofibroblasts : Mechanisms of fibrosis: therapeutic translation for fibrotic disease : Nature Medicine : Nature Publishing Group  "Pathways that elicit and recruit high numbers of myofibroblasts and those that engender resistance to apoptosis are active areas of fibrosis research"

Pentox decreases these Pentoxifylline Attenuated the Renal Disease Progression in Rats with Remnant Kidney

Myofibroblasts are found in smooth muscle, which make up a good percentage of the tunica albuginea.

Sulfasalazine stops myofibroblasts secreting the protein that prevents fibrosis from breaking down and also increases the rate at which activated hepatic stellate cells undergo apoptosis.

[Paolo]

Cheers skunkworks for re-post  
Paolo

[Paolo]

Skunkworks, I am supplementing currently with 5-LOX Inhibitor, too early to say if it is having an effect with Peyronie's   it is helping with joint pain however  

Found this on Sulfasalazine;

Drug Side Effects - A Tale of Many Colors
Sulfasalazine is an anti-inflammatory sulfa drug used to prevent and treat the inflammatory bowel diseases ulcerative colitis and Crohn's disease, as well as rheumatoid arthritis. It also has antibiotic properties that may be important in changing the bacterial content of the bowel. It's a potent remedy, but, like most drugs, it comes with a passel of side effects, ranging from common to rare, and mild to serious.

The common side effects of sulfasalazine are: headache; dizziness; ringing in the ears; irritation of the mouth or tongue; gastrointestinal discomfort and cramps; diarrhea; nausea and vomiting; brownish discoloration of the urine; and (perhaps not surprisingly) loss of appetite.

Among its more serious, but less common, side effects, are (in no particular order): aching joints and muscles; pain in the back, stomach, or legs; chest pain; swollen glands; peripheral neuropathy; allergic liver damage (hepatitis); bloody diarrhea; coughing; difficulty in breathing or swallowing; hearing loss; allergic reactions such as skin rashes, hives, and itching; bone-marrow depression; drug fever; sore throat; peeling, blistering, or loosening of skin; unusual bleeding or bruising; hemolytic anemia; allergic pneumonitis; kidney damage; severe skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis; anaphylaxis; pancreatitis; myopathy; drug-induced lupus erythematosus; pericarditis; unusual fatigue; and sensitivity to sunlight.1,2

WE'RE NOT DONE YET
You think that's it? Not quite. Last but not least is a bizarre spectrum of side effects that are, well, colorful. Depending on God knows what, you could have: whiteness or redness of the skin; blue discoloration of the skin, lips, or fingernails; and yellow discoloration of the skin or eyes. The stuff can even turn your contact lenses yellow!

Good grief! It's almost enough to make you not want to take sulfasalazine. Adverse effects limit the use of this drug, in fact, in up to 30% of patients.3 Although these effects are no laughing matter, the temptation to indulge in a bit of silly speculation about some of them is irresistible. Let's call it black humor.

So picture this, if you will: you're taking sulfasalazine, and different portions of your skin - those that haven't peeled, blistered, or loosened (or worse), anyway - simultaneously turn red, white, and blue (you could rent yourself out as a human flag!), while your eyes turn yellow and your urine turns brown. With your blue fingernails, you scratch your patriotic rashes, hives, and itches, all the while kissing your money goodbye with your blue lips and turning green with envy for people whose doctors gave them something less costly and more user-friendly - something like Boswellia serrata. By now those lucky folks are probably, uh, in the pink.

BOSWELLIA BEATS SULFASALAZINE
The botanical won! After six weeks of treatment, essentially complete remission of symptoms was found in 90% (18 of 20) of the Boswellia patients, and in 60% (6 of 10) of the sulfasalazine patients. Both of these outcomes are considered very good by any standard. Furthermore, none of the patients in either group showed any deterioration in any of the symptoms of their condition. The only side effect noted in the Boswellia group was heartburn, which affected two patients.

One year after the study began, follow-up examinations showed that 6 of the 18 improved Boswellia patients (33%) had had a relapse. In the sulfasalazine group, the percentage was the same: 2 of the 6 had suffered relapse. The authors suggested that treatment with higher dosages of Boswellia for longer periods of time might reduce this rather high relapse rate.

An earlier study by the same research group, by the way, had found that Boswellia serrata was effective against classic ulcerative colitis: after treatment with 350 mg three times per day, or 1.05 g per day, for six weeks, its efficacy was equivalent to that of sulfasalazine, with an 80% remission rate.7

5-LOX Inhibitor has a compound contained in boswellia called AKBA (3-O-acetyl-11-keto-ß-boswellic acid)9,10 is the key to its beneficial action.

On a total side note for those interested in Prostate health and high fat Western diet  Omega-6 read Inhibition of arachidonate 5-lipoxygenase triggers https://www.ncbi.nlm.nih.gov/pmc/articles/PMC23752/

Your thoughts are welcome, as I am no Doctor

[skunkworks]

Link to the source article please.

Edit, don't bother. It's Natural News type stuff and not even about arthritis.

The specific reason why sulfasalazine might be better than pentox is due to its action on Myofibroblasts. If you've got links to papers on pubmed about boswellia inhibiting the protein secretion from Myofibroblasts then I will be all ears.

[Realvinni2000]

Boswellia is now prescribed into the multimodal therapy here in Italy. The substance should have a positive effect toward elastase decreasing the lost of elastic fibers caused by the disease.

[melting]

Lots of possibilities to combat this.
Bring down the inflammation and do an ultra healthy lifestyle.
Magnesium and high dose vitamin C, for your penis applied via DMSO mix(rsearch!) might help you. Athritis is a problem with calcium and magnesium and vit C are balancing that.

[JayGould]

I would get an implant ASAP.