Antihistamines - suppressing TGF-β1 from fibroblasts

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marator

I see no one here is talking about antihistamines. Is there a reason for that, or have it just been overlooked.

from study:
"Antihistamines. Histamine H1 blockers are anti-inflammatory and antiproliferative agents that have been shown to inhibit the deposition of collagen80,81 and the synthesis of collagen in keloidal fibroblasts through suppression of the release of TGF-β1 from fibroblasts.1 In an in-vitro study,1 60 percent of cultured fibroblasts from normal human and keloidal skin showed elevated growth rates when exposed to histamine in a dose-dependent fashion, stimulation that was reverted in the presence of diphenhydramine hydrochloride in histamine-sensitive keloidal strains. A reduction in the proliferation rate (63%), in DNA synthesis (63%), and in the collagen synthesis rate (73%) was obtained after fibroblasts cultured from abnormal scars were exposed to pheniramine maleate.1 Relief of burning sensation, pain, and pruritus associated with keloids has also been reported.85,86"

Innovative Therapies in the Treatment of Keloids and Hypertrophic Scars

NeoV

I read this a few years ago and took antihistamines for a few weeks. It very well may be helpful.