Peyronies Society Forums

Please login or register.

Login with username, password and session length
Advanced search  


Please go to PROFILE then FORUM PROFILE to replace your signature line text with your profile info such as age, date of onset, symptoms, treatments tried, etc

Pages: [1]   Go Down

Author Topic: Caffeine thread  (Read 6292 times)

0 Members and 1 Guest are viewing this topic.


  • Global Moderator
  • ***
  • Country: jp
  • Offline Offline
  • Gender: Male
  • Posts: 1704
    • Neoman
Caffeine thread
« on: February 28, 2016, 04:49:18 PM »

It turns out there are many studies on coffee or caffeine and fibrosis. It is a xanthine derivitive just like pentox, and appears to work the same way by inhibiting TGF-beta and Smad2.

TGf-beta and fibrosis
2016- Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ, and reduces established fibrosis in ex vivo precision-cut lung slices -- Tatler et al. -- Thorax
2014 - Caffeine prevents experimental liver fibrosis by blocking the expression of TGF-β. - PubMed - NCBI
2008 - Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via
2009 - Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver
2009 - Less Smad2 is good for you! A scientific update on coffee's liver benefits - Gressner - 2009 - Hepatology - Wiley Online Library
2009 - About coffee, cappuccino and connective tissue growth factor-Or how to protect your liver!? - PubMed - NCBI
2008 - Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases. - PubMed - NCBI

Penis and erection
2012 - Caffeine relaxes smooth muscle through actin depolymerization. - PubMed - NCBI
2008 - Effect of caffeine on erectile function via up-regulating cavernous cyclic guanosine monophosphate in diabetic rats. - PubMed - NCBI
2004 - Effect of caffeine on response of rabbit isolated corpus cavernosum to high K+ solution, noradrenaline and transmural electrical

Inflammation in general
2013 - Effects of caffeine on the inflammatory response induced by a 15-km run competition. - PubMed - NCBI
2004 -
*My YouTube Channel*:

Talk to me on Skype


  • Major Contributor
  • ****
  • Country: ro
  • Offline Offline
  • Gender: Male
  • Posts: 6592
  • Age 71. Peyronies from January 2009
Re: Caffeine (Coffee) thread
« Reply #2 on: October 10, 2016, 02:55:22 AM »

Thanks NeoV, my blood pressure is low, so I can continue sipping the many daily coffees  ;D
Seriously I didn't see any negative side effects from coffee, just positive.

Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum
Pages: [1]   Go Up

Related Topics

  Subject / Started by Replies Last post
13 Replies
Last post April 29, 2012, 04:35:20 AM
by Luciano
18 Replies
Last post March 03, 2016, 03:22:01 PM
by Laveley
0 Replies
Last post February 05, 2018, 07:24:04 AM
by cheeznips