Protein injection heals damaged hearts in animals >> solution for Peyronies?

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Amitr

I just happened to come across this article which is about a Stanford research:

Delivering missing protein heals damaged hearts in animals, Stanford-led study finds
Researchers have discovered that a particular protein, Fstl1, plays a key role in regenerating dead heart-muscle cells.

https://med.stanford.edu/news/all-news/2015/09/delivering-missing-protein-heals-damaged-hearts-in-animals.html

What do you guys think could be the implications for it's potential to heal similar smooth muscle tissue in the penis?

Youngdude22

If I'm not mistaken most peyronie's is caused by damage to the tunica albugenia, not the smooth muscle. Damaged smooth muscle is essentially corporal fibrosis.  

kuaka

I gave a word picture in another thread describing what Peyronie's typically consists of.

Picture if you would a tube made out of cheese cloth (Tunica).  The fibers run lengthwise and around in a circle.  Put one of those balloons a clown makes animals out of inside the tube.  Inflate the balloon.  The length and girth of the resulting inflatable is constrained by the fibers of the cloth tube.

Deflate the balloon.  While it is "relaxed", put a blob of wax on the cheese cloth.  Let the wax harden.  Now, when you attempt to inflate the balloon, the tube constrains it into the bent shape of a typical Peyronie's sufferer, as the wax blob prevents that portion of the tube from being expanded to its "designed size and shape".  You can also have the wax "blob" in a circle all the way around (hourglass) or multiple blobs.

The balloon is NOT the problem here, and besides, erectile tissue is not really muscle.  There is actually very little "smooth muscle" in a penis.

A Nesbitt plication is about putting a blob on the other side to counter the bend (surgically damaging the Tunica opposite the plaque)...with a resulting loss of length which I personally cannot afford.  Call me "Shorty" if you must.  It can restore sexual function, however, is a possible solution for many.

Other Peyronie's treatments are about softening or removing the wax blob (scar tissue plaque), and restoring the ability of the cheese cloth sock (Tunica) to be expanded to near its original size and shape.  These can be done mechanically with surgery (which may stimulate additional scarring), chemically (Pentox/Cialis, Xiaflex and such), physically assisted chemically (Pentox/Cialis etc along with traction and/or VED) and so forth.  This last approach is the least intrusive, and the first place to start any treatment, in my opinion.  

The most invasive treatment would be an implant.  An implant would have its own constrained size/shape, eliminating the role of the Tunica entirely.  I consider such a solution a "last resort", almost as scary as a Nesbitt plication (which I consider quite Neanderthal).

Your mileage may vary.

kuaka