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Author Topic: Alternative Treatment  (Read 16102 times)

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Christopher1

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Re: Alternative Treatment
« Reply #50 on: April 28, 2017, 04:13:18 AM »

There needs to be a study done with this cream. Hmmm...
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Snake Diet + 5-day fasts + NeoV's stretching routine. Curvature 99% gone. Still have bothersome scar pain. Please message me for a good Peyronies Disease pain cure.

Big benefits experienced from a 2-month NoFap "flatline" (read about flatline) + cardio + Kegels

melting

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Re: Alternative Treatment
« Reply #51 on: April 30, 2017, 07:56:37 AM »

Pentoxifylline has a Molecular Weight: 278.31
This makes it a good candidate for transdermal delivery with DMSO.

We know that Pentox is widely used and described for Peyronies Disease. Many had no improvement with it. Im pretty sure that most oral supplements can have only marginal impact for the condition.
The plaque is sitting in the tunica at a place that hasn't much blood supply. So anything going systemical through the blood will only affect the site of the Peyronies Disease marginally and possibly urinated out of the system before doing any impact. This is simple logic. 
I guess it makes sense, to be blunt, if you would throw a Peyronies Disease-plaque into a 24hour/7days solution of Pentox or any other said to help drug, the pentox would have more impact then eating some pills.


Verapamil hydrochloride has a Molecular Weight: 454.611 g/mol.

So also able to be shuttled transdermal by DMSO.
Some good and some useless reports about it. The most useless obviously oral supplementation of it. Some bad reports cause injections created more scar tissue.
It also might work best on new plaques as a calcium channel blocker stopping the plaque from hardening.(calcification)

Vitamin E and Potassium Iodide are also able to shuttle through by DMSO.


It makes sense that this creme is possibly working. I used DMSO and VE and Iodine already in a DMSO solution and they softened my plaques.

To make it work Im also pretty sure that you have to use it as often as possible for the simple logic already laid out above. The more you "bath" the Peyronies Disease plaque in a helpful solution the more success.
10% dmso seemed to have worked for Perplexed, not sure if that isnt a bit on the low end.


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Christopher1

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Re: Alternative Treatment
« Reply #52 on: May 07, 2017, 09:13:05 AM »

What is DMSO's maximum carrier limit for molecular weight?
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Snake Diet + 5-day fasts + NeoV's stretching routine. Curvature 99% gone. Still have bothersome scar pain. Please message me for a good Peyronies Disease pain cure.

Big benefits experienced from a 2-month NoFap "flatline" (read about flatline) + cardio + Kegels

livinghell

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Re: Alternative Treatment
« Reply #53 on: May 14, 2017, 10:21:13 AM »

Through reading this thread I have gotten very interested in this topical application of Pentox. I started looking up pentox cream in google and came across this article which I found interesting. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228656/ This guy seems to very much support pentox even through a cream. I also came across this http://www.podiatrytoday.com/blogged/how-topical-compounding-has-worked-my-patients so I am hopeful towards this pentox cream and ways to get it leading me to this place Compounded Scar Cream | IPS Compounding . I still plan to do more investigating into this but I'm sure it'll give some ppl something interesting to check out
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Christopher1

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Re: Alternative Treatment
« Reply #54 on: May 14, 2017, 10:57:08 AM »

It would be challenging to find compounded pentox cream.
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Snake Diet + 5-day fasts + NeoV's stretching routine. Curvature 99% gone. Still have bothersome scar pain. Please message me for a good Peyronies Disease pain cure.

Big benefits experienced from a 2-month NoFap "flatline" (read about flatline) + cardio + Kegels

Paolo

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Re: Alternative Treatment
« Reply #55 on: May 14, 2017, 03:01:21 PM »

Hi livinghell, I also found below link, may interest you as it mentions Pentox along with DMSO

A Novel Compound Analgesic Cream (Ketamine, Pentoxifylline, Clonidine, DMSO) for Complex Regional Pain Syndrome Patients. compound analgesic cream (CAC)
ketamine 10%, pentoxifylline 6%, clonidine 0.2%, and dimethyl sulfoxide 6% to 10%.

https://www.ncbi.nlm.nih.gov/pubmed/26547813
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You throw sand against the wind,
And the wind blows it back again.

spyrosg

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Re: Alternative Treatment
« Reply #56 on: May 15, 2017, 09:52:50 AM »

Hi, guys...

isn't it a little peculiar how doctors, like -for example- Dr. Levine who prescribes the PAV, etc. and he is supposedly works with companies for a cream solution, have not tried or recommended something like a pentox based cream, up to now ?

Unfortunately, this disease has a lot of ''try and see'' procedures, by the patients themselves ...

We are taking pentox or other medicine, without a clue ... if we see no betterness, then (I do it) we feel that perhaps, in case we didn't get these things, the situation could be worsened .. and then, we keep on trying everything under the same concept.

For the time, it is 6 months now that i do ved every day, I take one or two pentox pills, and 1000 mgs of arginine ... no results ... but keep trying ... nothing better to do ... 
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livinghell

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Re: Alternative Treatment
« Reply #57 on: May 15, 2017, 10:08:47 PM »

Good find Paolo. It seems like there are small studies that support pentox in topical cream form yet there has not been a larger study. Which makes me wonder why. Is there not an effective ailment that this can properly be marketed for or does it simply not work in cream format. It seems to have worked in some capacity for Perplexed so I would hope to see others to benefit from it as well. So yes the skeptics are out why leading Peyronies Disease urologists haven't implemented pentox in cream form but I hope it has some merit and maybe we'll see it out soon. But spyrosg i just started my 26 week program a couple days ago and before I use the ved I usually heat up with a rice sock and gently massage the plaque areas with a sonicare for a good 10-15 mins before I put it in the ved. After my shower I then apply castor oil. This will be my go to routine for when I use the ved for the next six months and onwards towards recovery. I'm with you man just wish there was an idiot's guide to getting rid of peyronies.
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z01

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Re: Alternative Treatment
« Reply #58 on: August 21, 2017, 02:30:50 AM »

After reading this topic, I had done two things, firstly, I had written to Dr. Dennis to verify the validity of this post (this is the internet after all), he confirmed to me that this was indeed an actual case he had seen for a patient (no details discussed obviously beyond me asking him to confirm that this actually happened). He also told me that the dosage was actually very low and could be increased, but he suggested that (the dosage) as a preliminary "test run" initially to see if the patient responded. However, he did warn that the patient's success wasn't what would be considered typical, so there's that.

Upon having this confirmation I had a discussion with my doctor (showed him this topic and the email - cause you know, asking your doctor about "some guy online" usually doesn't work that well) on the possibility of him prescribing this medication for me to try out. After reviewing, he agreed that it had the potential to work simply based on the vera+pentox+DMSO mix, and further told me that the dosage could be increased (he settled on roughly double of what the OP's dosage was) and that is what I have received.

As I have only started the treatment this week it presumably should take some time before - if any - results are seen.

Let's see how things go.

Side note:

There really are a lot of dissenting opinions in the medical community about Peyronies Disease it seems... my doc hasn't put me on anything oral aside from 2.5mg cialis daily - in his words "just in case you have problems obtaining erections", yet on this board I've read that most are put on various oral regimes. Of course my question would be, of the ingested medication, what percentage would even reach the affected area due to low circulation of said area? Trans-dermal delivery of drugs right to the affected area in theory makes a lot more sense than ingesting but there seems to be very little interest in developing such medication mainstream?

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leland_mack

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Re: Alternative Treatment
« Reply #59 on: August 23, 2017, 05:30:39 PM »

Quote deleted by moderator. Read the forum rules

Haven't been here or posted for a while now. My treatment consisted of the usual, Vitamins, Pentox, Vacuum, used traction also. I feel I had my most improvement using traction and VED and saw no change with Pentox or Vitamin E or anything else.

I tried to have my doctor prescribe Dr. Dennis' formulation, at first he seemed receptive, on my next visit I brought formula and he balked saying he needed a more precise description than 10% this and 5% that.

This seemed strange to me, since one would think that all that is needed is to decide the total amount of medication you will make then compound the actives by percentage with the base carrier.

Made me think he was more interested in treating me than curing me.  Less money to be made by curing I suppose so I have not been back to him.

Still hoping to hear another success story from Dr. Dennis' compound.

If I do I am headed to Oregon, I have plenty of air miles available to use.
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z01

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Re: Alternative Treatment
« Reply #60 on: December 05, 2017, 05:18:05 PM »

Well it's been some 4 months almost, I had wanted to give a bit of an update sometime ago but never got around to doing that, apologies for anyone who was interested.

Around the 3 month mark of using the aforementioned formula I had started to see some improvement, in that (don't get this wrong) erections were becoming a bit... strange (as in you can feel some sort of stretch where the plaque is). Keep in mind that my Peyronies Disease started and resolved almost a decade ago (that's what my doctor figures and I never knew what the curvature was till my SO asked about it randomly) due to multiple injuries sustained. Now I've yet to check with my doctor about this development as it's not really a bother, but I figure that the plaque is being softened gradually and that it's about time that I tried to squeeze time in for traction to further develop on this.

That's about all that's happened to far. I believe this formula has been somewhat effective, my case is certainly not a 1 month cure as was the case for the OP, but I do think it's working.
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OBX

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Re: Alternative Treatment
« Reply #61 on: December 12, 2017, 11:11:28 AM »

Noting there hasn't been any more posts on this I wonder if anyone else has tried this topical cream?  Is there any update?
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Christopher1

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Re: Alternative Treatment
« Reply #62 on: December 16, 2017, 11:45:51 AM »

I want to try it, but do not know how to find someone who can prescribe this compounded formula.
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Snake Diet + 5-day fasts + NeoV's stretching routine. Curvature 99% gone. Still have bothersome scar pain. Please message me for a good Peyronies Disease pain cure.

Big benefits experienced from a 2-month NoFap "flatline" (read about flatline) + cardio + Kegels

TonySa

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Re: Alternative Treatment
« Reply #63 on: December 16, 2017, 01:09:00 PM »

Any medical provider (MD, DO, NP, PA, etc) who can prescribe can call in a Rx to a compounding pharmacy for you.  Just have to find a willing provider.  Most who describe their practice as “integrative medicine” are likely to do so.  As it will be generic, the cost can be quite reasonable.
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PxD 2 yrs, failed all tx. 9/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS 18cm + 3rte

diehardpatriot

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Re: Alternative Treatment
« Reply #64 on: March 04, 2018, 02:35:21 AM »

HAs anyone else tried this?)
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17 year old who had stable peyronies. Now battling a new acute injury. Don’t know wtf my symptoms r

webfoot35

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Re: Alternative Treatment
« Reply #65 on: December 07, 2018, 01:04:09 AM »

I am wondering if the OP, z01, or anyone else who has used the cream has experienced any further success? If so, please keep us updated.
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bigwilly

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Re: Alternative Treatment
« Reply #66 on: December 27, 2018, 04:17:11 AM »

Wow Perplexed your doctor sounds amazing.  He literally created a cream specifically to help with your illness, very rare that a doc would go out on a limb. 

Curious, what state is he in?  Also is he a urologist or a GP?
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bigwilly

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Re: Alternative Treatment
« Reply #67 on: December 27, 2018, 04:32:16 AM »

Wow I actually live 2 hours away from Portland, Oregon.  What are the odds?  Unfortunately it appears that Dr. Dennis Lee is no longer practicing.  Is that true, Perplexed?
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Bubba dawg

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Re: Alternative Treatment
« Reply #68 on: December 27, 2018, 07:50:55 AM »

I am going to talk to my doctor about this as soon as we get more confirmation from members long term results. Side effects etc. I can see where this would be a lot better than oral. I still need more improvement. Sometimes it looks 90%. Sometimes it looks 70 % improved from xiaflex treatments. Looks very promising. I wonder why there is no xiaflex penetrating  cream?
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5 Rounds of Xiaflex. Good results

james1947

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Re: Alternative Treatment
« Reply #69 on: January 01, 2019, 07:48:51 AM »

One year on with no new report.
Two possibilities (maybe more)
* Cured himself and now he is rich from patenting the formula
* Didn't cured himself and I don't know...

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum
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