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Perplexed

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Alternative Treatment
« on: February 25, 2015, 04:40:23 PM »

My doctor just told me I have Peyronies Disease (on penis and both hands) and has ordered a cream containing pentoxifylline.  Has anyone had success with this treatment?  Any side effects?
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Nemo

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Re: Alternative Treatment
« Reply #1 on: February 25, 2015, 07:41:59 PM »

What you have on your hands is not technically Peyronie's (though the conditions are seen to be related) - it's called Dupuytren's Contracture. 

I have never heard of Pentox being available in cream form and am slightly concerned that your information is off to begin with.  Are you certain this is what he has prescribed?  What is the name of the medication?

Nemo
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Perplexed

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Re: Alternative Treatment
« Reply #2 on: February 26, 2015, 12:43:38 AM »

My doctor is having the cream specially formulated and prepared to his specifications by a comppending pharmacy so there is no brand name.
Thanks for enlightening me about the situation with my hands.
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NeoV

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Re: Alternative Treatment
« Reply #3 on: February 26, 2015, 05:05:53 AM »

Hi Perplexed,

Pentox containing cream has not been studied, and it is not something any of us have heard of. This is big news to us (to me at least).
While it may have a positive effect, please stick to the standard treatments, these are oral Pentox, daily low dose Cialis, and supplements such as Citrulline, CoQ10, Acetyl-L-Carnitine. Also consider the physical therapy options which include traction and VED therapy, which are both to be done with extreme caution, but still have a very positive effect on Peyronie's. The treatments I outlined above are effective for many of us given enough time.

By all means try the pentox cream, I know I would, but first I would take it orally. Studies on pentox and cialis and other supplements on penis health and fibrosis are good.

Thanks for the heads up, let us know how it goes!
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Perplexed

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Re: Alternative Treatment
« Reply #4 on: February 26, 2015, 12:09:17 PM »

I have a rather serious heart condition (cardiomyopathy) so my urologist is loath to prescribe anything orally that could possibly inimically counteract the stabilizing therapeutic regimen my cardiologist has had me on for several years.  The urologist wants to try the cream initially to assess the results and will move to a more aggressive approach (in consult with my cardiologist) if necessary to treat the Peyronies.   
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Jonbinspain

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Re: Alternative Treatment
« Reply #5 on: February 27, 2015, 02:16:13 AM »

Perplexed;

Presumably, this compound will include something like DMSO to allow the other ingredients to penetrate the dermis?
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Perplexed

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Re: Alternative Treatment
« Reply #6 on: March 02, 2015, 12:28:19 PM »

Yes, the prescribed compound has 10% DMSO for dermal penetration.
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Perplexed

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Re: Alternative Treatment
« Reply #7 on: March 09, 2015, 11:21:21 PM »

I just started to use an ointment formulated by my doctor for Peyronies.  The ointment was prepared by a compounding pharmacy to my doctor's specifications.  The ointment is to be applied to the affected area twice a day and I have applied it for three days so far.  I will let you know if I experience any improvement.  My doctor told me that the formula containes very minimal quantities of the active ingredients and my have to be modified if positive results are not attained.
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melting

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Re: Alternative Treatment
« Reply #8 on: March 12, 2015, 06:55:22 PM »

Sounds intriguing. topical transdermal makes the most sense as it goes where it is needed in contrary to oral meds.
I think it should work better then if you took it oraly.


The ointment was prepared by a compounding pharmacy to my doctor's specifications. 


Do you have the possibility to describe the ingredients and their amounts?
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Perplexed

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Re: Alternative Treatment
« Reply #9 on: March 20, 2015, 09:46:20 PM »

Sorry for the delay in replying to your posts regarding the ointment for my Peyronies.  Here are the components and quantities:

Pentoxifylline 5%
Verapamil 5%
Vitamin E 1%
Potassium Iodide 8%
DMSO 10%

The doctor agrees that using the ointment topically has a better chance of effectiveness than an oral medication.  The doctor said I won't notice any remarkable improvement for at least 4-6 weeks.  I'm in my second week right now. 

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Skjaldborg

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Re: Alternative Treatment
« Reply #10 on: March 20, 2015, 09:57:07 PM »

I don't see how Pentox would be useful in a topical compound. Pentox works by making the red blood cells "squishier" so they can better bring oxygen and nutrients through smaller capillaries. It also has a mild anti-fibrotic effect. You really need to ingest significant quantities on a daily basis for several months to see results with it. I don't know if it's absorbed well through the skin.

-Skjald
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james1947

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Re: Alternative Treatment
« Reply #11 on: March 20, 2015, 10:25:07 PM »

I will second Skjaldborg regarding Pentox.
Regarding Verapamil, proposing you to read the Verapamil board, not helped too many (if at all)
What is/are the rest of 71% of the compound? (5+5+1+8+10=29%)

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
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Perplexed

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Re: Alternative Treatment
« Reply #12 on: March 22, 2015, 09:47:18 PM »

I have no idea what the additional 71% is composed of but I believe it is a benign cream ointment to contain the medicinal components. 

Perplexed
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james1947

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Re: Alternative Treatment
« Reply #13 on: March 22, 2015, 11:12:56 PM »

Quote
I have no idea what the additional 71% is composed
Also an answer. If it was me, I was asking the doctor before using it.

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

Perplexed

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Re: Alternative Treatment
« Reply #14 on: March 23, 2015, 10:04:30 PM »

James:

I have all the faith in the world in my doctor.  I believe if there were any other medicinal components they would have had to be listed along with the other active ingredients.  I only know one thing -- its working!

Perplexed
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Nemo

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Re: Alternative Treatment
« Reply #15 on: March 23, 2015, 10:54:55 PM »

How so?
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Perplexed

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Re: Alternative Treatment
« Reply #16 on: March 24, 2015, 07:18:31 PM »

When I first developed Peyronies my urine flow had a 45 degree angle to the right.  Now it is flowing straight from the urethra.  Also, the plaque is diminishing in size and firmness.  Erections are straighter. 
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basebend

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Re: Alternative Treatment
« Reply #17 on: March 31, 2015, 12:04:59 PM »

Quote removed by moderator - James,
Please read the forum rules!!!


If that's really true that sounds promising. Please post more updates, I'm very interested to see if it's actually working.
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Perplexed

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Re: Alternative Treatment
« Reply #18 on: April 02, 2015, 08:50:48 PM »

I have had excellent results from the treatment that I have been using for about three weeks.  Plaque has been reduced by 75% and I am confident that it will be totally gone with another several weeks of medicine application.   
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james1947

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Re: Alternative Treatment
« Reply #19 on: April 02, 2015, 09:50:16 PM »

Sounds like excellent results Perplexed :)
Please keep us updated.

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

Nemo

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Re: Alternative Treatment
« Reply #20 on: April 02, 2015, 10:51:26 PM »

Perplexed, not to be a wiseguy, but I'm a bit perplexed by your case.  Your doctor felt it would be 4-6 weeks before you might notice major results, and in only 3 weeks you've seen a 75% reduction in the plaque!  If accurate, that is nothing short of astounding, especially for an apparently ad hoc concoction of topical agents.

If these results are 100% legit, I would ask that you invite your Urologist to join the discussion here so that he may share his treatment protocol or any research that gives rise to it with us. While it's impossible to draw any general conclusions from one isolated case, if he has experience with this treatment and has seen similar results, he really needs to share this with others.

Not to draw too sharp a comparison, but we had a similar topical treatment blow up several years ago, all based on what one guy somewhere was supposedly given by his grandfather, a doctor. The so-called "Thacker's Formula" (which was DMSO based) simply didn't pan out for anyone, save for this one guy (who was only accessible to ONE member of the forum), who swore it cured him. Eventually "Thacker" disappeared and a lot of empty bottles of DMSO, apple cider vinegar and castor oil went into landfills across America. 

Additionally, no one is going to be able to go to their Uro and say, "Hey I read about this guy on the internet who had results mixing this and this and this - can you order me some of that?"  But if your doctor makes his presence known here, the treatment could be given much more substance.  I say I'm perplexed, because here you have the largest collection of men on the internet suffering with Peyronies Disease, and none of us have ever heard of using Pentox topically in solution with anything. Your doc is tilling new soil here and we need to know more than an isolated anecdotal report of improvement like "my plaque shrunk 75% in 3 weeks."  I'm not trying to cast doubt on your results; frankly, I hope like heck they're 100% accurate.

Your doctor's participation here would be greatly appreciated by the Peyronies Disease sufferers, I guarantee. 

Thanks and continued success,
Nemo
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goodluck

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Re: Alternative Treatment
« Reply #21 on: April 04, 2015, 02:58:20 PM »

Perplexed, 


This is much welcomed news.    I can see you are new here so you may not know about all of the "dry holes" people have dug. False hopes, etc..... skepticism becomes a natural reaction to something simple, fast and effective.
Again...keep us informed.
Can you share your Doctors name, city and state?


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james1947

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Re: Alternative Treatment
« Reply #22 on: April 04, 2015, 06:02:53 PM »

Perplexed

I would like also to have the doctor name, location etc', it may help other forum members if they will decide to go in your way.

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

Perplexed

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Re: Alternative Treatment
« Reply #23 on: April 05, 2015, 09:49:03 PM »

I have been reading much of the forum posts and can well understand much of the skepticism, but I can only relate my personal experienced.  When I quoted my doctor as saying the results may take 4-6 weeks I interpreted that to mean it would take about that long for full issue resolution.  I find things are favorably progressing as he anticipated.
   
The name of my physician is Dr. Lee Dennis, ND and you can find him at his website: namastenaturalhealing.com.  He is located in Portland, Oregon but would, I believe, be willing to consult with you personally over the phone.   As you would expect the Doctor's professional consultations are not without compensation but very reasonable.

Perplexed 
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Nemo

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Re: Alternative Treatment
« Reply #24 on: April 06, 2015, 12:09:55 AM »

Perplexed, thanks very much for sharing that information.

Again, let me say, I don't mean to doubt the results you are claiming, but if I may be perfectly honest, the source of your treatment is a bit discouraging to me. Most of us don't even live in a state where so-called Naturopath doctors can be licensed (I think about 17 states currently recognize the degree and allow them to practice medicine).  The fact that your doctor is not a board certified Urologist, but rather a Naturopath general practitioner, and also gave you to believe that something like Peyronie's Disease, which has baffled medical science for centuries, could find "full resolution" period, much less in 3-4 weeks, gives me to wonder if he is not simply throwing several things at the wall in the form of a topical solution and hoping something sticks. If this were an effective strategy, or based in sound science, I have to believe some of our leading Uro's like Leu or Levine or others would have tried it before (maybe they have - if so, they don't currently). 

However, the single most important thing here is that you feel your condition is improved, and that being the case, whatever the nature of that improvement, I congratulate you. But the fuller picture, admittedly, leaves me less inclined to believe we're dealing with a practitioner forging a new breakthrough in the treatment of Peyronies Disease. 

I'm only offering one man's opinion, of course.  And as I've said many times, I would LOVE to be proved wrong, especially if it comes in the form of a fellow sufferer being "healed" - so continued progress to you. 

Thanks again,
Nemo
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Jonbinspain

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Re: Alternative Treatment
« Reply #25 on: April 06, 2015, 02:48:51 AM »

It has always made sense to me that, if and when an effective treatment is found for this, it would be in the form of something applied directly to the problem, rather than anything taken orally. Most oral medication, supplements, etc are used up in the body before they get to the intended target.

Like Nemo I would love to believe that this actually works. However, reading of the ingredients, I'm sceptical. I don't doubt the sincerity of Perplexed, but suspect that his improvement may just be coincidental. If more people were to come forward saying that this treatment had helped them, I might start to believe.
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clarke58

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Re: Alternative Treatment
« Reply #26 on: April 07, 2015, 05:05:43 PM »

hi all my name is steve and about 15 years ago i had pain in my penis and it was painful to have a orgasam  so i when to a uralagest sorry about the spelling he said i had peyronies  but i had no curveature and he told me about what the onitment with veraparil in it it cam from a lab i dont know what all was in it but i can tell you that  it worked but here i am 15 years later with the same problem due to to much masterbation so i know it does work just saying
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Nemo

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Re: Alternative Treatment
« Reply #27 on: April 07, 2015, 05:32:47 PM »

You're referring to Topical Verapamil from "PDLabs" in San Antonio, Texas.  In the years since its introduction, that treatment has been overwhelmingly discredited both by anecdotal experience from the many of us who used it (myself included) and by direct surgical tissue examination by doctors (Levine, for instance), who found the Verapamil simply did not penetrate the tunica at all. If you believe TV cured you, you're welcome to that belief, but I'd tell you the overwhelming majority of its users feel we wasted a lot of time and money. 

Nemo
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goodluck

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Re: Alternative Treatment
« Reply #28 on: April 08, 2015, 12:21:24 AM »

Perplexed,

Thanks for sharing the ND you are working with.   I think it is great you are having beyond remarkable results.  If you had a 25% improvement in 4-6 weeks I would say that would be remarkable.  You are doing great!

As I mentioned before I can fully understand the skepticism. 

Did your Doctor share with you his overall experience with this topical cream?  i.e. How long has he been working with it, how many men have used it and  how many had good results? I am sure, Like everything the results fall on a scale from none to very good.

Did he warn you of any potential side effects?

I would not discount this approach because it is being used by a ND. They take a different approach than MD's. In some cases ND's help a lot of people where main stream MD's fail.  The fact that they may not be approved for license in some states is just politics.
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james1947

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Re: Alternative Treatment
« Reply #29 on: April 10, 2015, 06:15:12 PM »

Perplexed

I added the doctor to our list.
Keep us updated on your progress. :)

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

Youngdude22

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Re: Alternative Treatment
« Reply #30 on: August 03, 2015, 11:23:54 AM »

I will be flying to Oregon later this month to see Dr. Dennis. I will let you guys know how it goes.
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leland_mack

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Re: Alternative Treatment
« Reply #31 on: August 04, 2015, 10:55:30 AM »

Youngdude22,

Please do come back and give us an update. Like many I am skeptical but also hopeful you will posting good results in the weeks ahead.

Leland
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leland_mack

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Re: Alternative Treatment
« Reply #32 on: August 05, 2015, 05:16:34 PM »

Just a quick update, visited my Urologist this afternoon. After the examination I showed him the listing of the topical ingredients given here. He said we see two items we know might work verapamil and pentoxifylline, and then commented on the DMSO penetrating ability. He told me if I started seeing more positive reports here on this mixture, and I wanted him to he would have it compounded for me. Basically nothing about the compound alarmed him.

Leland
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james1947

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Re: Alternative Treatment
« Reply #33 on: August 05, 2015, 07:54:12 PM »

leland_mack

You have stated:
Quote
I showed him the listing of the topical ingredients given here
Please remember this forum is not advising or promoting this compound in any way or form.
It is a compound that one forum member use it successfully from his report.

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

leland_mack

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Re: Alternative Treatment
« Reply #34 on: August 06, 2015, 03:00:22 PM »

OK James, I understand. I won't post my experiences with my doctor again.
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james1947

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Re: Alternative Treatment
« Reply #35 on: August 06, 2015, 05:11:00 PM »

leland_mack

You can post your experience with your treatment, but a sentence that sounds like the treatment is endorsed by the forum is not appropriate as the treatment is not endorsed by the forum.
Such a statement misleads other members.
I am sure many members, including myself, reading your posts with eagerness as we all are interested to learn everything we can to fight this horrible disease.

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

leland_mack

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Re: Alternative Treatment
« Reply #36 on: August 06, 2015, 05:52:51 PM »

James1947

Thanks for the clarification, never thought I was endorsing anything, just wanted to make the point that one medical doctor, my Urologist was not alarmed by the contents.

So my point is before putting anything in or on yourself that does not have a well established efficacy, it would be wise to seek the council of an M.D.!

Don't gamble with your health, stakes are too high.
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Re: Alternative Treatment
« Reply #37 on: August 07, 2015, 07:15:36 AM »

leland_mack

I agree, do not gamble with your health, any time you are choosing to try something new with a medication or herbal product vitamin of any kind always consult your physician, you never know what it can counteract with that you may already be taking, even though it may be safe on its own, mixed with something else could be hazardous.

hugs, Mamma
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leland_mack

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Re: Alternative Treatment
« Reply #38 on: August 08, 2015, 07:30:53 AM »

Stabler

During my last physical 6 months ago, I presented a complete list of all the supplements and vitamins I take. The Dr. cautioned me about excessive Vitamin E just as an example and told me to limit Vitamin E to 1000 I.U. a day. After running a full blood panel the Dr. added Vitamin D to my list.

During my initial visit to my Urologist, I took the same list and the Urologist issued the same warning as the GP about excessive E.

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Re: Alternative Treatment
« Reply #39 on: August 08, 2015, 08:17:12 PM »

Unfortunately many people think that because it is a "vitamin" that "the more the better" but that is not the case, vitamins need to be a well balanced combination. you CAN have to much when it comes to even a vitamin so everyone please make sure you are watching what you put in your bodies.

Hugs Mamma
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goodluck

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Re: Alternative Treatment
« Reply #40 on: August 16, 2015, 11:29:37 PM »

It has been about 4 months now since Perplexed told us about his great initial results.

  Perplexed, are you out there?  How are you dong now?

Please chime in and let us know your status.
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AdaBrown

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Re: Alternative Treatment
« Reply #41 on: August 17, 2015, 04:38:42 AM »

[Full quote remove - Admin]

Agree. The more the better policy can not be applied into vitamin consumption. The over absorption of some type of vitamin can be very harmful to our bodies. So the suggestion is taking vitamin as the doctor suggests.

[Commercial site link removed]
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leland_mack

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Re: Alternative Treatment
« Reply #42 on: August 17, 2015, 07:54:50 AM »

I am hoping we will get a good report from Youngdude22. If we do I will make an appointment with my Urologist to get the mix compounded.  Perplexed hasn't posted since April, I wonder why.
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Perplexed

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Re: Alternative Treatment
« Reply #43 on: August 17, 2015, 04:24:30 PM »

Hello Everyone

Sorry for my lack of alacrity responding to your questions.  My peyronies has been resolved by about 90%. There is still a very small nodule but the curvature is essentially gone and there are no other effects or indications from the disease.  My doctor said that the prescription he gave me can not penetrate the shaft entirely and he is reluctant to increase the strength of the formula to capture the last 10%.  I was pleased that the prescription was topically administered rather than orally since I do not like taking medications of any sort -- except for those needed for therapeutic purposes for treating my hypothyroid and cardiac issues.

Perplexed
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Youngdude22

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Re: Alternative Treatment
« Reply #44 on: August 18, 2015, 01:13:11 AM »

I have postponed my trip to see Dr. Dennis until December. I want to give the pentox/COQ10 a fair shot before I pursue other lines of treatment. Also I tried a MSM/DSMO gel for a few days and had an adverse reaction, which made me concerned about trying this DSMO based gel Dr. Dennis prescribes. I skipped using it for one day and I noticed an immediate reduction in girth, which was enough for me to stop it. My girth returned back to normal over the next week thankfully. If the pentox doesn't achieve the results I'm looking for then I will probably take a trip to see Dr. Dennis to give it a shot. By the way Perplexed, what stage of peyronie's were you at when you began using the topical from Dennis?
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leland_mack

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Re: Alternative Treatment
« Reply #45 on: December 23, 2015, 02:03:42 PM »

Its December Youngdude22, let's us know what happens if you visit Dr. Dennis.
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Perplexed

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Re: Alternative Treatment
« Reply #46 on: April 14, 2017, 10:23:49 PM »

Hello Everyone.

Sorry for my absence from the forum, but I've had several major medical issues to deal with.  In June I was diagnosed with prostate cancer -- luckily it was found in the very early stages and had not migrated from the gland. A prostatectomy was performed robotically in September.  My PSA after six months is 0.01 which is non-detectable, but the lab will never give a reading less than that.  After quickly recovering from the prostate surgery, I was diagnosed with two hernias -- one left and one right.  I had them repaired in January and have fully recovered.  I'm hopeful my medical issues have subsided for the time being.   

The Peyronies has not improved beyond the 90% level since I last posted.  I have a very small module just behind the glans but the large module left side mid-shaft is gone.  I have also been putting the ointment Dr. Lee prescribed on my hands (as suggest by my nephew who is an orthopedic surgeon specializing in hands).  The left hand Dupuytren’s Contracture is about 80% resolved while the right had as not responded quite as well -- about 40% resolution. 

I hope this information is helpful and somewhat encouraging.

Perplexed
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james1947

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Re: Alternative Treatment
« Reply #47 on: April 15, 2017, 03:37:15 AM »

Perplexed

Happy to hear that your problems solved very good.
Your results with Dr. Lee DMSO based cream are remarkable. I wish I was living closer and can get my hands on that cream :)

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

Paolo

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Re: Alternative Treatment
« Reply #48 on: April 15, 2017, 03:44:27 AM »

Hi Perplexed, nice to have you back  :)
Your positivity is inspiring in the face of cancer, I wish you all the best, it at least (for me) puts into perspective the benign condition of Peyronie's.

I hope you will keep in touch  :)
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“You will never reach your destination if you stop and throw stones at every dog that barks.”

melting

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Re: Alternative Treatment
« Reply #49 on: April 15, 2017, 05:22:27 PM »

Applying transdermaly locally makes so much more sense with peyronies. Orally can be supplementally but chances that it reaches the site of peyronies are small.

Actually DMSO could deliver anti cancer medicine too. Keep that in mind if anything bugs you again.

Thanks for updating us and good luck with staying healthy!
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