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Author Topic: Proanthocyanidins for nitric oxide and less TGF-beta  (Read 2841 times)

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NeoV

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Proanthocyanidins for nitric oxide and less TGF-beta
« on: February 13, 2015, 09:18:28 AM »

Oligoneric proanthocyanidins, found in grapeseed extract and pinebark extract among other sources, increase nitric oxide in the body, and have been studied on ED and vascular disease, now commonly being included in bodybuilding "pump" or pre-workout products along with Citrulline etc.

The main mechanism appears to differ from Citrulline and Arginine as well as Cialis, originating from their ability to block calcium ions and activate p-AKT. The best erections I had were when I took pine bark (often sold as pycnogenol). Grapeseed extract is cheaper however so I have switched. Other popular sources are Hawthorn berry and Shizandra berry.

Aside from increasing nitric oxide, proanthocyanidins have a large range of good effects on one's body, preventing fibrosis, atherosclerosis, edema, and acting as an anti-inflammatory and antioxidant. In fact I think I originally bought pine bark extract to treat my edema.

Pharmaceutical and nutraceutical effects of Pinus pinaster bark extract

Here is the mechanism.

"(GSE) upregulates eNOS and NO by inhibiting insP3Rs-mediated intracellular excessive calcium release and by activating p-AKT in endothelial cells."
Grape seed extract enhances eNOS expression and NO production through regulating calcium-mediated AKT phosphorylation in H2O2-treated endothelium. - PubMed - NCBI

GSE also inhibits estrogen as it is an aromatase inhibitor.

Moreover, they inhibit TGF-beta and other Peyronie's suspects
"GSE attenuated the As-induced changes in the serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and IL-1β and the mRNA levels of TGF-β1, α-smooth muscle actin (α-SMA), connective tissue growth factor (CTGF) and fibronectin (FN) in renal tissue. Furthermore, administration of GSE markedly reduced As-stimulated reactive oxygen species (ROS) production and Nox activity, as well as the protein expression levels of the NADPH subunits (Nox2, p47phox and Nox4). In addition, GSE cotreatment was correlated with a significant reduction in TGF-β/Smad signaling, as demonstrated by the decreased protein levels of TGF-β1 and pSmad2/3 in renal tissue. This study indicated that GSE may be a useful agent for the prevention of nephrotoxicity induced by chronic exposure to As. GSE may exert its effects through the suppression of Nox and inhibition of TGF-β/Smad signaling activation."
Grape seed extract attenuates arsenic-induced nephrotoxicity in rats


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lonelyboy

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Re: Proanthocyanidins
« Reply #1 on: February 13, 2015, 11:46:33 AM »

Nice one, I think I'll be adding this to my regime, good find.
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skunkworks

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Re: Proanthocyanidins for nitric oxide (Grape seed, Pine Bark etc)
« Reply #2 on: February 21, 2015, 01:49:08 AM »

Pycnogenol was the most effective non prescription substance I had/have ever used with regards to erection strength and frequency.

MoatazKad

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Re: Proanthocyanidins for nitric oxide (Grape seed, Pine Bark etc)
« Reply #3 on: March 19, 2015, 06:00:20 AM »

With regards to the grape seed extract and the citrulline mate which supplement brands do you recommend. I am thinking NOW and Jarrow Formulas as two of the better companies out there. I'm curious with regards to those who have seen benefits with them whether they were taking them on an empty stomach or not?
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james1947

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Re: Proanthocyanidins for nitric oxide (Grape seed, Pine Bark etc)
« Reply #4 on: March 19, 2015, 06:23:29 AM »

Proposing you MoatazKad to buy a bottle and test it in a laboratory if you have the money for it!!!
Why, in the link bellow :(:
http://www.peyroniesforum.net/index.php/topic,6008.0.html
Myself bought L-Citrulline Malate from SWANSON, but what they really have inside, who knows? :(

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

NeoV

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Re: Proanthocyanidins for nitric oxide (Grape seed, Pine Bark etc)
« Reply #5 on: March 21, 2015, 04:50:23 AM »

I recommend primaforce due to it being cheap and in powder form. Use a straw as to not erode your teeth enamel. The structure is similar to malic acid.

As for GSE, I am not too sure. I tend to go for lowest price and all these things.
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MoatazKad

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james1947

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Re: Proanthocyanidins for nitric oxide (Grape seed, Pine Bark etc)
« Reply #7 on: March 25, 2015, 07:23:38 AM »

I am just wandering what should be the daily doses of Pycnogenol.
NeoV has stated 2*100 mg.
So wahy soo many manufacturers making capsules of 30 and 50 mg?
Just wandering.

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

MoatazKad

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Re: Proanthocyanidins for nitric oxide (Grape seed, Pine Bark etc)
« Reply #8 on: March 27, 2015, 07:04:18 AM »

i think the daily or recommended dose is 100mg.
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