Side effects Pentoxyfiline and xiapex

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Dutchie2014

Hi there, I just wanted to introduce myself. I am 43 years old and according to the urologist I have Peyronies Disease. It must have happened during sex about 1 year ago where my penis snapped and from that moment it hunted for about 1 month and suddenly showed an upward 45 degree angle. I am not much of a medicine taker a I believe they do more harm than good so to treat it I took the most common known things as vitamine e, quercitine, bromelaine and minimised the intake of certain food. I also went to an acupuncturist to have lymphatic treatment and use a deep scar creme based on herbs which I rub in with the help of a moxa stick for local heat treatment. This I must say is helping a little bit, I have no problem in getting an erection, ejacualating or urinating and have no hourglass look but it has become shorter and the top half is thinner as less blood is getting there . I went to an expert urologist yesterday at the university hospital of Groningen in the Netherlands. He basically dismissed all of the treatments discussed here in various topics such as Pentax , VED etc. he said the most promising thing is XIapex but it is currently disapproved by the EEC. Although I read it has been submitted again for approval on the 25th of June 2014 by sobi.com . Does anybody have news on this? I also would like to know if anyone can describe their experience with Pentoxyfiline and especially the side effects as I have been described this now cause it was the best current medicine according to him but without guarantee.  I also participated in a genetic study because it is known that in China Peyronies Disease is not existent . Thanks for your answers!

james1947

Xiaflex have excellent outcome according to our forum members report.
Expert urologist that dismissing the treatments on this forum, supported by the world leading Peyronies experts, seems to me not updated on the available treatments.
You may find in the library researches that are supporting them.
Regarding Pentox, proposing you to read the topics that may be of interest for you at:
Oral Treatments for Peyronie's Disease - PDS - Peyronies Society Forums
One more point:
Quoteit is known that in China Peyronies Disease is not existent .
Wrong. If it is true, why have many Peyronies "herbal" and not herbal specialists in China?

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

UrsusMinor

There are no reliable statistics on the prevalence of Peyronie's by country.

That said, I don't know where you got the idea it is "unknown in China." Here is an article about advanced plication surgery for Peyronie's in China:

http://www.amepc.org/tau/article/view/1707

Here is an article about herbal remedies used in Japan, which the article states are also used in China under different names:

http://peyronies-disease-help.com/peyronies-treatment-options/honso-herbs-peyronies-treatment/

Traditional Chinese Medicine has also been applied to Peyronie's in China, and there is a lot of published research on the condition...but mostly in Chinese. Here is a summary in English of one study:

http://www.townsendletter.com/Dec2004/chinesemed1204.htm

I don't believe that Peyronie's is unknown anywhere-just underreported.

Dutchie2014

Thanks Ursusminor & james1947 for your comments. The remark that in China peyronies does not exist was told to me by this urologist, he was the one that invited me to join this genetic study and the study is being done together with the university of California. I will also forward the links to him to hear his comments.

LWillisjr

Dutchie2014,
I have contacts at Auxilliam (manufacturer of Xiaflex. I will see if I can confirm re-submission for EEC approval.
Developed peyronies 2007 - 70 degree dorsal curve
Traction/MEDs/Injections/Surgery 2008 16 years Peyronies free now
My History

Dutchie2014

Thanks for that LWillisjr, meanwhile I searched the EMA website but that is not easy to get through even though it says that XIapex has been approved for the EU the info dates from 2013 and seems not to be updated. Further I found following Swedish company stating :

Sobi files for EU approval of Xiapex for Peyronies disease
2014-06-25
Swedish Orphan Biovitrum AB (publ) (Sobi) and Auxilium Pharmaceuticals, Inc.today announced that Sobi has filed for an extension of the label for Xiapex® (collagenase clostridium histolyticum) with the European Medicines Agency (EMA) to include the indication of Peyronie's disease.

But I also found a report where they request 1 year marketing protection which seems to me you do when it has not been approved. But I cannot find any hard evidence for the rejection.