I received PIRFENIDONE....any advice??

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yyy

Hi Everyone

I received 30 Pirfenidone tabs from India. They are made by Cipla, so they should be 100% legit.
I read that he could be a very useful drug against Peyronies, as it inhibits tgfBeta1.
I'd like to try it orally, but Im pretty scared and know nothing about dosage.

MattFoley

Never heard of this stuff but it looks interesting.

"The typical starting dose is 200mg of Pirfenex (Pirfenidone), taken 3 times a day. Dosage can be adjusted by your physician in accordance with progress. It is recommended that dosing is done after a meal or snack." -- http://www.unitedpharmacies.com/Pirfenex-Pirfenidone.html
Got Testosterone?

yyy

This is the dosage for IPF, polmunary fibrosis.

I can't understand if this stuff blocks the fibrosis or can reverse it. I need something to reserve, blocking is useless in my case

Skjaldborg

I'm not a doctor or an expert on this, but from the study description on wikipedia it appears to only arrest rather than reverse pulmonary fibrosis. This makes sense to me because once scar tissue is formed, it is very difficult to get rid of as it replaces healthy tissue.

Also, we don't know how this drug performs on penile tissues, which are different from lung tissues. Perhaps it can slow down or stop scar tissue in the tunica, but there do not appear to be any studies on it. Pentox does have studies showing a favorable response. I would stick with what we know can work.

Perfinidone has side effects, including increasing liver enzymes, which Pentox does not commonly do. Worth noting.

-Skjald

MattFoley

"The antifibrotic effect of pirfenidone has been further established in animal models of cardiac,[22][23][24] renal,[25][26] and hepatic[5][27][28] fibrosis. In these models, pirfenidone demonstrated a consistent ability to reduce fibrosis and the expression of fibrogenic mediators." -- Wikipedia

So from my reading of this, it reduces existing fibrosis and helps prevent further incidences of it.

I can't find a dose specific to Peyronie's. The dose I posted is a good starting point. If it were me, that's where I would start.
Got Testosterone?

james1947

YYY

My advice is:
Start from asking a good general practitioner doctor!!!

James  
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

yyy

It's an off-label drug, I don't need a physician as he would not approve its usage.
I will start with half tab ED, let's see what happens....

pey ron

@yyy: did it work for you? also: how/where did you find it?
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pey ron

does anyone know yyy's email address? his mailbox is full :(
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thinkpositive


LWillisjr

Click on the envelope in his signature block. His PM may be full, but you can send him an email via the forum.
Developed peyronies 2007 - 70 degree dorsal curve
Traction/MEDs/Injections/Surgery 2008 16 years Peyronies free now
My History

pey ron

I'm sorry... I don't see an envelope (or a signature block)
Please go to PROFILE then FORUM PROFILE to replace this signature line text with your profile info such as
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LWillisjr


It is the area to the left of every post.

Developed peyronies 2007 - 70 degree dorsal curve
Traction/MEDs/Injections/Surgery 2008 16 years Peyronies free now
My History

pey ron

I see the envelope for you, I don't see it for yyy. Probably you see it for everybody because you are a moderator.
Please go to PROFILE then FORUM PROFILE to replace this signature line text with your profile info such as
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LWillisjr

Developed peyronies 2007 - 70 degree dorsal curve
Traction/MEDs/Injections/Surgery 2008 16 years Peyronies free now
My History

hope794

26 yo from Italy.
Peyronie's since abt 2014
Abt 20-25° bend, w/ a moderate twist to the left
ED for 4 years and getting worse
From pornstar-like to moderately depressed - still fighting for a solution.

pey ron

@LWillisjr: did yyy ever reply to your email?
Please go to PROFILE then FORUM PROFILE to replace this signature line text with your profile info such as
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relationship status, etc
** You will waste less time and get better answers **

LWillisjr

Developed peyronies 2007 - 70 degree dorsal curve
Traction/MEDs/Injections/Surgery 2008 16 years Peyronies free now
My History

pey ron

he's been online on here ever since though... how does he possibly not notice any of us? :(
Please go to PROFILE then FORUM PROFILE to replace this signature line text with your profile info such as
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** You will waste less time and get better answers **