I have found studies that say that nitric oxide is wonderful. All these studies concern short periods of supplementation from 1-6 months. As I mentioned I have been taking L-Arginine
for over a year each day. A month ago I started looking for information about this supplement. It turned out that no one had yet conducted a detailed study on long-term intake of L-Arginine. However, there are suppositions that long-term supplementation of this amino acid can have very serious consequences, such as can impair the blood system, excess nitrogen oxide can also lead to imbalance and cause cell death.Czy opłaca się stosować argininę? Obalamy fakty i mity! | Meduzo
"Our body, when it has arginine surplus, launches various metabolic pathways.
Initially it synthesizes a small amount of nitric oxide through cNOS, later it starts producing more NO through iNOS.
Too much NO just reverses the entire action of arginine upside down.
Instead of lowering, it increases the pressure instead of giving flexibility to the walls of the blood vessels, stiffening them instead of protecting against the infarction, accelerating it and harming the kidneys.
Arginine also increases acidity in the stomach. This is done by stimulating gastrin production and can aggravate digestive problems.
Arginine can affect changes in potassium, especially in people with liver disease."
"Does L-arginine lower blood pressure and reduce the risk of heart attack?
The question is directly related to the topic: nitric oxide as a powerful signaling compound.
Arginine is a precursor of nitric oxide, and the compound itself dilates blood vessels, lowers blood pressure, and increases tissue elasticity.
This hypothesis only works with a short-term, single dose of arginine!
This time the results of research with long-term administration of arginine and its effect on the cardiovascular system have turned out to be shocking !!
Steven P. Schulman and colleagues investigated how arginine affects people at risk of heart attack.
Expect health improvement. Certainly no one thought that arginine sufferers could die!
The study group consisted of 153 people given 3g of arginine / 3x daily.
The study was not completed because 6 people died in arthritis who were supplemented with arginine !!!
After this unhappy fact, the researchers immediately decided to stop the study.
Romero's findings have been unfavorable for the heart and vascular system.
100 patients (3g of arginine / 3x daily) were studied. The results showed that a greater amount of arginine results in an increase in iNOS and arginine activity leading instead to the elasticity of the membranes, to stiffening the vessel walls and increasing the risk of infarction!
Still other studies indicate that arginine supplementation leads to fibrosis
and decreased myocardial responsiveness, left ventricular hypertrophy and decreased myocardial performance during the study. These studies also had to be interrupted!
Short-term supplementation was positive, but long-lasting tragic.
Arginine lowers cardiac output, increases the risk of heart attack and does not lower blood pressure !!
1. Steven P and inn, L-Arginine Therapy in Acute
Myocardial Infarction JAMA. 2006; 295: 58-64.
2. Medical College of Georgia (2008, February 1). Diabetes Makes It Hard For Blood Vessels To Relax. ScienceDaily. Retrieved June 25, 2009,
3. Arginine Fails to Prevent Ventricular Remodeling and Heart Failure in the Spontaneously Hypertensive Rat Wesley W. Brooks and the Inn"