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Author Topic: Understanding the course of Peyronie's disease (int. J. of Clin P. Aug. 2013)  (Read 3415 times)

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Note - This the latest review of the medical literature of the most current understanding of, and the most effective treatments for Peyronies. It is very good, and is the current end-all-be-all of current medical understanding of Peyronies. I would like to post a PDF of the entire article, but I do not seem to have permissions to do so. Members of this forum may contact me via email, and I will send them the entire article if they wish. I will try to post the entire article at a later time.

Understanding the course of Peyronie's disease

    G. Garaffa1,
    L. W. Trost2,
    E. C. Serefoglu3,
    D. Ralph1,
    W. J. G. Hellstrom3,*

Article first published online: 22 JUL 2013

DOI: 10.1111/ijcp.12129

© 2013 John Wiley & Sons Ltd

International Journal of Clinical Practice
International Journal of Clinical Practice

Volume 67, Issue 8, pages 781–788, August 2013


To correct common misconceptions about Peyronie's disease (Peyronies Disease) that present obstacles to early recognition and treatment.

The prevalence, natural disease course, psychosocial effects and treatment considerations for patients with Peyronies Disease were reviewed.


Studies over the past decade have shown that the prevalence of Peyronies Disease may be higher (up to 20%) than previously thought. Peyronies Disease can lead to emotional and relationship distress. Nearly 10% of men who present with Peyronies Disease are younger than 40. Both younger age and comorbid vascular disease have been associated with more severe and progressive Peyronies Disease. In the majority of patients, symptoms will either deteriorate or remain stable. Peyronies Disease is often associated with erectile dysfunction (ED). Effective, minimally invasive treatments used early in the disease course include unapproved and/or investigational intralesional injection therapy with verapamil, interferon (IFN) α-2b, or collagenase clostridium histolyticum (CCH). Surgical intervention is considered in patients with ED and/or penile deformity that impairs sexual functioning; however, preoperative discussion of appropriate expectations is important.


The availability of effective minimally invasive and surgical therapies for Peyronies Disease suggests that active management should be considered over a ‘wait-and-see’ approach.


Providing early intervention and improved education/awareness of Peyronies Disease as a chronic and progressive disorder may result in improved physical and psychosocial outcomes for Peyronies Disease patients. As general practitioners are often the first contact for men with Peyronies Disease, they are well positioned to recognise symptoms early and promptly refer patients for further evaluation and treatment.



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