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Author Topic: Hybrid H-100  (Read 25126 times)

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skunkworks

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Re: Hybrid H-100
« Reply #50 on: February 28, 2016, 07:24:57 PM »

This was mentioned in the paper Dros found:

Topical treatment for acute phase Peyronie's disease utilizing a new gel, H-100: a randomized, prospective, placebo-controlled pilot study. - PubMed - NCBI

Quote
Abstract

Safety and efficacy of topically applied gel H-100 composed of Nicardipine, superoxide dismutase and emu oil for treatment of acute phase Peyronie's disease (Peyronies Disease) was evaluated. Twenty-two patients (Peyronies Disease <12 months duration) were studied in a prospective, randomized, double-blind, placebo-controlled study. Eleven patients received H-100 and 11 patients received placebo for 3 months. All 22 patients then received H-100 for the final 3 months. Flaccid-stretched penile length, degree of penile curvature, pain level and side effects were assessed monthly. H-100 showed significant improvement in all Peyronies Disease parameters at 6 months: mean stretched penile length increase (22.6%, P=0.0002), mean curvature reduction (40.8%, P=0.0014), and mean pain level reduction (85.7%, P=0.004). Placebo group showed no significant improvement except for mean stretched penile length increase (6.8%, P=0.009). Crossover patients from placebo to H-100 showed significant improvement in all parameters: mean stretched penile length increase (17.5%, P=0.000007), mean curvature reduction (37.1%, P=0.006), and mean pain level reduction (40%, P=0.17). Treatment was well tolerated. A self-limited rash was the only side effect in three patients. Statistically significant improvements in flaccid-stretched penile length, curvature and pain suggest that H-100 is a safe and possibly effective non-invasive, topically applied treatment for acute phase Peyronie's Disease.International Journal of Impotence Research advance online publication, 24 December 2015; doi:10.1038/ijir.2015.22.

NeoV

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Re: Hybrid H-100
« Reply #51 on: February 28, 2016, 08:02:51 PM »

That study was very recent (posted in pubmed in December 2015).

In the review Dros posted,

"Recently, a small placebo controlled trial of topical nicardipine and superoxide dismutase
compounded with emu oil in 22 men with untreated acute phase Peyronies Disease demonstrated
significant improvement in multiple Peyronies Disease parameters (length gain, curvature reduction,
pain scores) compared to placebo"
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Freemason

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Re: Hybrid H-100
« Reply #52 on: February 28, 2016, 09:47:39 PM »

Neo...yea I've done lots of reading on their compounds..I think all 3 have potentially a synergistic affect...but SoD has been studied alone with Peyronies Disease patients a while ago with moderate success in all parameters.  SOD is highly powerful anti oxidant and anti inflammatory.  As for the Emu Oil it's commonly used in expensive skin/face creams for wrinkles/scars etc..has transdermal effects.  I just haven't taken time to have a pharmacy compound me some. I'm sure u could get a Uro to prescribe the calcium channel blocker...pretty harmless on our penis.  Any way...you'll have to have a compounding pharmacy with the rx for calcium compound u a gel with these ingredients. If u look enough on their product you can find the patent and they list out the ingredients and percentage of each used.
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Dros

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Re: Hybrid H-100
« Reply #53 on: March 01, 2016, 04:03:57 AM »

Here's the patent: http://www.google.com/patents/EP2804606A1?cl=en

H-100 is:
20% Nicardipine
0.2% SOD
1% gelling agent (e.g. fatty acids)
78.8% Emu Oil

I will ask my Uro to prescribe me this :-)
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skunkworks

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Re: Hybrid H-100
« Reply #54 on: March 01, 2016, 05:07:11 AM »

Was there ever a definitive answer on how important (or not important) DHT is in an adult penis? The  linolenic acid in emu oil is a reasonably potent 5 alpha reductase inhibitor, so it could decrease the levels of DHT in the penis.

DHT is essential to development of the penis, but I am not sure how important (if at all) it is for an adult penis.

Jack1909

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Re: Hybrid H-100
« Reply #55 on: March 01, 2016, 08:31:00 AM »

I think DHT is important to preserve the tissues integrity. I don't have any scientific proof of it but I know for sure that some people who take finasteride/propecia for hairloss develop tissue changes, scarring and sometimes a real Peyronie.
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NeoV

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Re: Hybrid H-100
« Reply #56 on: March 01, 2016, 03:16:26 PM »

That's interesting to note, however the results of the trial seemed to suggest the formula can overcome this. Still could be a reason to be wary.

It looks like it has quite a lot of the nicardipine, and not much SOD, unless 0.2% is a lot.

I have been reading online about emu oil, and I cannot find any information regarding it's mechanism of action for being a trans-dermal carrier, though it is repeatedly touted as one on emu oil websites. One writer thought olive oil or any fatty acid would and should do the same thing.

It would be important to see a good study on how the stuff works. Because I might as well just use grape seed oil and SOD and see how that goes.

Anyway, I guess this stuff really is mostly nicardipine. I hope we can use it and see how we feel in not too long.
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Re: Hybrid H-100
« Reply #57 on: May 07, 2016, 03:15:08 PM »

It's a lot of SOD..doesn't take much. Just read up on SOD a little and you begin to realize that this compound is prob the most powerful antioxidant scavanger there is to date. One interesting thing I read recently is h2o2 a lot of doctors don't want people using it for cuts etc because it prohibits scaring over to take place, it's really just a debriding agent..intersting. Peroxide inhibits fibrosis from forming...at all. So in theory using peroxide in the acute and very early phase might do something?  If only u could discover a way to get it into the skin..idk.
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skunkworks

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Re: Hybrid H-100
« Reply #58 on: May 08, 2016, 01:48:58 AM »

That is really interesting Freemason re peroxide. I will be reading up on that.

Freemason

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Re: Hybrid H-100
« Reply #59 on: May 08, 2016, 10:54:28 AM »

Yea I was just reading online an old text book on oxidizing compounds and stuff...it seems older texts, when all these compounds were discovered, have a lot of interesting info and I came across Peroxide.  There's a cult group of folks who firmly believe in drinking very small amounts of it to cleanse and do various things. I'm not advocating that. I had a friend who was into it decades ago and I tried it for a week or so. Nasty nasty tasting. We are talking a couple drops in a full glass of water and it completely alters the water.  Some theorize that by raising oxygen levels you eliminate bad stuff etc..

One other thing I thought about...Liposuction..there are all kinds of diff types and techniques but I wonder if one could have it done on the plaque? Lol. Seems crazy prob. There is Air lipo dome by the top guys in Beverly Hills but it just under skin in fat layers. I guess no plastic surgeon is skilled enough to get thru the nerve bundle into the plaque without destroying your dick.  Any way..dumb idea never mind.
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skunkworks

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Re: Hybrid H-100
« Reply #60 on: May 08, 2016, 12:14:22 PM »

Google any lipo video and you'll forget that idea very quickly. It's basically a person getting stabbed with a metal straw hundreds of times.

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Re: Hybrid H-100
« Reply #61 on: May 08, 2016, 12:51:19 PM »

Lol. Yea I've seen it. Idk I just thought there's got to be a way of just sucking out the plaque without damaging stuff..I guess u have to replace it with something though. Hence the graft.
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Pey-penis

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Re: Hybrid H-100
« Reply #62 on: May 17, 2016, 03:05:07 AM »

There's a cult group of folks who firmly believe in drinking very small amounts of it to cleanse and do various things. I'm not advocating that. I had a friend who was into it decades ago and I tried it for a week or so. Nasty nasty tasting. We are talking a couple drops in a full glass of water and it completely alters the water.  Some theorize that by raising oxygen levels you eliminate bad stuff etc..
For a long time I am drinking hydrogen peroxide 3% every day in the form of "lemonade" consisting of 1/2 cup of water, a tablespoon apple cider vinegar, a teaspoon of honey or syrup of pine shoots, and 50 drops of pure hydrogen peroxide 3%. To this amount of H2O2 I was slowly went up for several months. The only visible effect of this is a regrowth of black hair instead of gray and not actually fall back on any type of  catching cold disease for several years. I support this way the bacteria e-coli, where the byproduct of the activities in the large intestine is the production of H2O2. It is indispensable for macrophages, which uses it to perform "oxygen explosions" thus destroying pathogens.
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jim morrison

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Re: Hybrid H-100
« Reply #63 on: July 27, 2016, 05:49:34 PM »

At least orally, they do not think SOD can be absorbed in the body unless coated and carried through liposomes. Here are a couple links to products that I found with topical liposomic SOD and how it is beneficial for anti inflammatory diseases. The last link is a report stating that SOD may be beneficial for peyronies. In this instance they use iontophoresis to drive it home.  Also, this narcidipine is a calcium channel blocker just like Verapamil so I wander if it would be beneficial to use SOD while using a topical Verapamil if you can get it to penetrate? Maybe it will give a similar or even better outcome of the H-100. Just a thought.

[I removed the commercial links as we don't want to promote sales for these products. I left the book link for information purposes]

https://books.google.com/books?id=07ucAgAAQBAJ&pg=PA194&lpg=PA194&dq=can+i+mix+verapamil+and+superoxide+dismutase&source=bl&ots=NLyvl9sCbp&sig=cdP1CokcuLF9RyMbDII4FsA-F5I&hl=en&sa=X&ved=0ahUKEwijotjUpJTOAhUi7YMKHaFhCe4Q6AEIYDAJ#v=onepage&q=can%20i%20mix%20verapamil%20and%20superoxide%20dismutase&f=false
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peyter

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Re: Advice on new trial
« Reply #65 on: November 21, 2016, 07:36:24 AM »

Dear all,

I have found:

Innovation | Hybrid Medical
http://www.nature.com/nrurol/journal/v13/n2/full/nrurol.2016.6.html Study about H-100 trials.

Any info about a comercial launch?

Is that the same H-100 product?

Thanks!!!
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james1947

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Re: Advice on new trial
« Reply #66 on: November 21, 2016, 09:12:49 PM »

The link posted by Peyter yesterday November 21, 2016
&
The link posted by Funnyfarm on April 26, 2013
Is the same link.
So what happened during 3 & 1/2 years?
If it is such a miracle cure, they were billionaire already from the sales of this cream

James
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spyrosg

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Re: Advice on new trial
« Reply #67 on: November 22, 2016, 05:37:04 AM »

May i point out that the two recent posted liks refer to some hopefull indications out of the performed study, that were published almost 11 months ago...

Let us all hope that some more positive info will soon flow in ...

Member ''Freemason'' was supposed to try mixing his own version of H-100, but I don't recal seeing any updates
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Lucketts

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Re: Advice on new trial
« Reply #68 on: November 22, 2016, 07:07:47 PM »



Outstanding research, gentleman.  Please keep up apprised of anything further you learn.
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Freemason

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Re: Advice on new trial
« Reply #69 on: November 24, 2016, 01:26:17 AM »

May i point out that the two recent posted liks refer to some hopefull indications out of the performed study, that were published almost 11 months ago...

Let us all hope that some more positive info will soon flow in ...

Member ''Freemason'' was supposed to try mixing his own version of H-100, but I don't recal seeing any updates


Correct..but I never got around to it:(. But boy I would love to.  I do live somewhat near Minneapolis i could just make an appt with the Urologist who is heading this and tell him to just write me a RX compounded..the Pharmacy they used for the formulation is in Minneapolis..My question would be how come none of these 22 men have come on this forum?  I mean I'm very happy if this product works for Acute phase patients but how about the millions that aren't in the Acute phase anymore?
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Lucketts

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Re: Advice on new trial
« Reply #70 on: November 24, 2016, 10:16:44 AM »



Freemason, you are a prophet ahead of your time!

Perhaps when they do trials, they have to be very selective and well defined, and just focussed on the acute phase as a starter.

Just learning about compounding pharmacies.  By making a lot of drugs themselves, they seem to be a lot more flexible, and can sell drugs (i.e. cialis) at a fraction of the price of a drug store.
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pizzaman

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Re: Hybrid H-100
« Reply #71 on: November 30, 2016, 02:09:12 PM »

A quick google search shows a bunch of oil-based SOD creams. I may try one as an experiment.
I am no longer in the acute phase, but still get some pain/irritation and palpable inflammation.
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Paul52

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Re: Hybrid H-100
« Reply #72 on: January 30, 2017, 06:45:31 AM »

Hi all,

Has anybody tried making and applying the H-100 gel? Any results?

I'm in the acute phase and willing to make/try it.

Best,
Paul
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Re: Hybrid H-100
« Reply #73 on: January 30, 2017, 11:07:48 AM »

Paul52, I think this has all gone quite, if you are willing to try it please update when you can

Emu Oil, SOD and narcidine where the main ingredients, think this gel is dead in the water (scam)  :(
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Freemason

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Re: Hybrid H-100
« Reply #74 on: March 03, 2017, 06:30:16 PM »

It's not dead in the water yet..I haven't gotten around to having a pharmacy mix it myslef..But they are in phase 3 trials I believe..Have a feeling it will be more beneficial for those in acute phase rather than chronic phase..based on the ingredients it a lot of anti inflammatory stuff etc..

But hey if it works some that's great for anyone..

Oh...and I hate this f ing disease..
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pey ron

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Re: Hybrid H-100
« Reply #75 on: February 05, 2018, 12:01:28 AM »

I can easily compound stuff. Where to source the SOD though?
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MJohn

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H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #76 on: March 04, 2018, 06:00:45 PM »

Now to find a doc that will prescribe it! 

Hybrid Medical – H100 Peyronie’s Disease Treatment

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TonySa

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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #77 on: March 04, 2018, 08:30:25 PM »

Any idea on the cost?
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NeoV

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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #78 on: March 04, 2018, 08:59:48 PM »

Oh man... Here we go. How to get our hands on this... The science looks incredibly simple, but I like simple. Very exciting.
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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #79 on: March 04, 2018, 10:05:30 PM »

Looks like the compounding pharmacy is promoting it, just fax a prescription.  Please let us know the cost.
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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #80 on: March 05, 2018, 06:54:49 AM »

A very exciting development, any member trying this please post back with testimonials in 3-6 Months.

Why hasn't Hybridmedical made contact with this forum of 1'000s of members????  ???

Hope it rolls out internationally  :)
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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #81 on: March 05, 2018, 10:04:02 AM »

If anyone gets prescribed this in Illinois please let me know what doctor did it for you.

Thanks!
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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #82 on: March 05, 2018, 10:29:18 AM »

I guess it bothers me that they haven't released the results of the 'trial' that included a whopping 22 people. This treatment has not been approved by the FDA to treat anything. My uro won't prescribe unapproved treatments and no ones insurance will cover it. Just seems sketchy to me. They also mention on their site that H 100 is more effective for those in the acute phase so that eliminates 98% of the members here as far as max benefit. Sorry, can't get too excited about this
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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #83 on: March 05, 2018, 12:28:01 PM »

It’s not available in California, damn. Anyone know why it’s omly available for certain states even tho it all comes from the same pharmacy ?? Also, wasn’t there a guy who ended up making his own H-100 using the exact formula a while back with no results ?? Anyway, still kind of exciting
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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #84 on: March 05, 2018, 01:01:23 PM »

Ya I hear you on the 22 people in the study.  they do say it works best in the acute phase but anyone can benefit from it.  The ingredients are fairly innocuous, the Nicardipine being the only ingredient needing a prescription.  Like most of us on here, I will try it if the cost isn't too crazy and I can get my doc to prescribe it.  I will be printing out the documentation and prescription form and going to give it a whirl and see if I can convince my Doc to give me a script.   
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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #85 on: March 05, 2018, 04:28:17 PM »

If we have the formulation, any compounding pharmacy can do it.  I suspect that particular pharmacy marketing it does not have a license in CA
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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #86 on: March 06, 2018, 01:16:38 AM »

a guy who ended up making his own H-100 using the exact formula a while back

who's that? I'd love to send them a message and ask them where they procured the ingredients, to try it myself
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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #87 on: March 06, 2018, 01:51:45 AM »

Yo, we do have the formulation. I have a screenshot of it from a post in the forum a while back . The problem is getting a doc to prescribe it. Since it sounds crazy giving him a list of crap to compound you. Now that it actually Has a name and brochure, and someone who actually perfected the compound, it’s much easier to pbtain IMO. But us Californians aren’t so lucky this time. The compound I saw was. Anyway , isn’t Hybrid medial the only pharmacy that can make this now? Did they put a patent on it?

20 percent Nicardipine
.2 percent SOD
1 percent geling agent
78.8 percent emu oil
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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #88 on: March 06, 2018, 02:46:08 AM »

I can easily make it if I manage to get the ingredients. I have precision scales, a magnetic stirrer and the stir bars and the borosilicate bekers. Just like in a lab :P
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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #89 on: March 06, 2018, 08:59:59 AM »

Is your name Heisenberg?
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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #90 on: March 06, 2018, 01:06:07 PM »

Ya know if you read the studies they cite as evidence for their formula, only the SOD and the EMU oil have studies to show topically they help fibrosis and inflammation.  The Nicardipine study they tout is for injectable version not topical.  And if you think about it, there are many things that have been shown to be effective when injected.  Even saline injected has been shown to help and they surmise the physical injection in the scar tissue actually helps to break down and remodel the scar.  MY point of all this is it really seems that the EMU and SOD are the only things that possibly could make a difference topically.  PLUS, they mention manually tugging on your member multiple times per day.  I am thinking about getting EMU oil and SOD cream and tugging on it for 30 seconds multiple times per day. 
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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #91 on: March 06, 2018, 01:32:20 PM »

MJohn, I love your eagerness here but I think you would also need a calcium channel blocker, that would be the Nicardipine, by all means give emu and SOD a go meantime but I presume H-100 should become available soon  :-\
If a calcium channel blocker increases oxygen by widening arteries I presume the SOD is required to mitigate or limit damage resulting from this  :-\ I wish I understood this better.
Presume the manual stretching along with H-100 breaks up the plaque over 3-6 Months??????
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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #92 on: March 06, 2018, 02:04:01 PM »

 The beauty of a compounding prescription is any compounding pharmacy can make it themselves. The study is published by Dr. Levine out of Chicago
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JS1991

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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #93 on: March 06, 2018, 08:50:56 PM »

Awesome news!! Can't wait to add this to my current regimen. I actually had my first urologist appointment today and got referred to a Peyronie's/ED specialist, so I plan on printing out the brochure and bringing it with me when I go to see him. Will update as things happen!

pey ron

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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #94 on: March 06, 2018, 10:17:49 PM »

Tsanchez12369: how to find a compounding pharmacy in the US???
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TonySa

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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #95 on: March 07, 2018, 09:30:07 AM »

Just google compounding pharmacy
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Freemason

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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #96 on: March 08, 2018, 02:18:02 PM »

you could try your own Emu Oil mix and SOD but they have looked at the pharmacology of all the ingredients combined to give maximum penetration and effectiveness...hence the studies.  SOD is arguably the strongest anti inflammatory compound known..

I’m def going to use it..cant hurt..I don’t care about cost..I’d spend $20,000 for a straight penis. Heck more...

I’m guessing it is more effective for acute phase bc in that phase lowering inflammation is critical, however those wiht pain (fortunately im not one) might benefit from this compound i’d Guess..

Hope so.


Guess we will know in 6 months right.
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TonySa

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Re: Hybrid H-100
« Reply #97 on: March 08, 2018, 02:31:29 PM »

The patent has multiple formulations, any idea which formulation they landed on?
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TonySa

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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #98 on: March 08, 2018, 02:33:25 PM »

Is Dr Levine using it as he was one of the original authors?
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PxD 2 yrs, failed all tx. 9/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS 18cm + 3rte

skunkworks

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Re: H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!!
« Reply #99 on: March 08, 2018, 06:48:52 PM »

Are there not many different kinds of SOD available? Which one are they using?
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