Topic: Hybrid H-100 (Read 28912 times)

pey ron · « **Reply #100 on:** March 09, 2018, 01:45:15 AM »

where do you buy SOD in powder form?

TonySa · « **Reply #101 on:** March 09, 2018, 04:38:26 PM »

Freemason, how much was it?

Paolo · « **Reply #102 on:** March 10, 2018, 06:06:38 AM »

It appears the SOD required would be LrhSOD, known as Lipoxysan, 1.4 mg SOD/day ,see an old study below;

http://www.europeanurology.com/article/S0302-2838(05)00256-3/fulltext

Note the following;
Response to other disease parameters was assessed at week 12: plaque size was reduced in 47% of patients, as was plaque consistence in 38%. Penile curvature was improved at 5–30 degrees in 23% of patients. Very effective for pain reduction.

It was demonstrated that a significant amount of lrhSOD reaches deep layers of the skin and also adjacent deeper tissue

A total of 39 patients were evaluated in the study.

pey ron · « **Reply #103 on:** March 10, 2018, 05:02:33 PM »

thanks Paolo!

unfortunately, I don't even see it on Alibaba...

diehardpatriot · « **Reply #104 on:** March 10, 2018, 06:46:15 PM »

Has anyone ordered H-100 yet? If it was available in Cali I would’ve filed a prescription already

Freemason · « **Reply #105 on:** March 11, 2018, 01:52:41 PM »

I haven’t gotten it yet but I’m gonna call Levine office for a RX.. I saw him about 2 years ago..my first real appt. but I elected to not have grafting. I have upward bend about 45 degrees. Lost inch at least..

So if I can use this I’ll use it for year or more i don’t care it’s non invasive and can’t hirt and has been studied so..

Heck of it improves my curve by 10-20 degrees I’ll be happy.. I’m also gonna do some light traction with it as well and ask for low does Cialis.

TonySa · « **Reply #106 on:** March 11, 2018, 04:26:20 PM »

Can you ask him the formulation? % of each ingredients for those of in CA who can’t order directly?

swiss · « **Reply #107 on:** March 13, 2018, 09:55:39 AM »

Can you just call Levine and he'll give you an RX??

Freemason · « **Reply #108 on:** March 14, 2018, 07:46:22 PM »

I called Monday but they havent called me back..lady said on phone since its been 2 years i might have to have another appt..which is bs..nothing has changed and I live 4 hours away. Stupid.

I can prob just make an appt wiht the Dr. in Minnesota who helped create it..im 5 hours from there but actualy do work up there so can stay for free.

Crooked_Stick · « **Reply #109 on:** March 15, 2018, 12:48:41 PM »

any word on the cost of the H-100 treatment? Thinking about emailing my uro to see if he has/would prescribe (which is doubtful since it's not approved)

TonySa · « **Reply #110 on:** March 16, 2018, 01:39:36 PM »

This pharmacy doesn’t even have a phone number—very suspicious to me, but I’ve emailed them....

Crooked_Stick · « **Reply #111 on:** March 16, 2018, 03:16:18 PM »

Messaged my Uro here in Houston, TX.....he is "not prescribing H-100 at this time".

swiss · « **Reply #112 on:** March 16, 2018, 03:40:40 PM »

Send that dude a letter full of glitter for his help

TonySa · « **Reply #113 on:** March 16, 2018, 04:32:13 PM »

I just requested Dr Lue to prescribe it. If he does i’ll Let folks know the price and any progress after using.

franklee · « **Reply #114 on:** March 17, 2018, 12:55:15 PM »

The cost for H-100 is 290.00 per month based on a 3 month supply. They will discount 50.00 per month if you complete survey which seems easy enough. This is from Hybrid Medical directly. Dr. Twidwell is listed as inventor. I did patent search. Levine is not mentioned.

TonySa · « **Reply #115 on:** March 17, 2018, 01:43:15 PM »

They both wrote the medical article.

pey ron · « **Reply #116 on:** March 17, 2018, 04:23:20 PM »

@franklee: wait, how many months does one need to apply this for???

@paolo: we really need to find a source for LrhSOD/Lipoxysan...

diehardpatriot · « **Reply #117 on:** March 17, 2018, 05:27:58 PM »

So it’s mad expensive . Anyone think it’s worth trying? Or maybe anyone know where to get it for cheaper or make your own? How much cheaper would it be to just ask ur uro to write an RX for the same ingredients and take it to a compounding pharmacy? I luckily can afford H-100 , should I guinea pig it ?

TonySa · « **Reply #118 on:** March 17, 2018, 05:31:02 PM »

If we can get the exact concentrations of the three components there are much more reasonably priced compounding pharmacies. Does anyone know, the patent lists multiple formulations so I don’t know which one they used. Maybe I’m not reading it correctly?

diehardpatriot · « **Reply #119 on:** March 17, 2018, 05:53:28 PM »

It’s on their website tsanchez in the brochure. Has all the ingrefients

TonySa · « **Reply #120 on:** March 17, 2018, 10:11:10 PM »

The ingredients yes, but I’m wondering the strengths of each.

franklee · « **Reply #121 on:** March 17, 2018, 10:12:48 PM »

my understanding is it is a 3 month prescription. Recommended use is 6 months.I can afford it but I'm wondering if any of my Drs. will fill out RX form. Also, not having the experience of many members I'm not as confident it's anywhere near the answer we have all been waiting for. I know Dr Levine was involved in the study but isn't involved with the roll out of this highly anticipated drug. Does anyone know if he is using it for his patients?
I'm probably going to use it if I can get a Dr. to fill out RX. I'm trying everything else I read about on this forum.

pey ron · « **Reply #122 on:** March 18, 2018, 02:34:49 AM »

is it the same as this? Some additional information on lrhSOD and Peyronies Disease - Peyronies Society Forums

also, can't we merge these two threads?

Hybrid H-100 - Peyronies Society Forums
H-100 TOPICAL IS FINALLY AVAILABLE!!!!!!!!!!!!!!!!!!!! - Peyronies Society Forums

pey ron · « **Reply #123 on:** March 18, 2018, 02:42:15 AM »

Impact of Superoxide Dismutase-Gliadin on Radiation-induced Fibrosis: An Experimental Study

LWillisjr · « **Reply #124 on:** March 19, 2018, 07:51:09 PM »

Quote from: pey ron on March 18, 2018, 02:34:49 AM

also, can't we merge these two threads?

Done

Brookfield56 · « **Reply #125 on:** March 20, 2018, 09:14:42 AM »

My doctor is ignoring my request for a prescription. Any other way to get this?

Crooked_Stick · « **Reply #126 on:** March 20, 2018, 10:12:39 AM »

Maybe contact the company and ask them who in your area is prescribing, my Uro will not since it is not approved......some docs will prescribe just about anything...

Freemason · « **Reply #127 on:** March 22, 2018, 03:23:07 PM »

$300 month is Meh..i spend $200 month on cable and internet. I’ll give it a shot for 6 months if i can get a RX. I’ll take the chance of it working some. If it can improve me by 20-30% i’ll Be thrilled.

pey ron · « **Reply #128 on:** March 22, 2018, 04:30:49 PM »

has anyone started using this?

I am about to get it prescribed. I am planning to use my HSA debit card to cut the cost in half by using pre-tax money.

Given it would still be pretty expensive I am already wondering how to maximize its absorption and how to minimize how much gets rubbed into my underwear...

I have been trying the following with the diclofenac/voltaren gel: right after I apply it, i wrap my weiner into king film. The problem is that the cling film tends to roll up into a ring. But under that ring the gel stays fresh for hours. Outside of the ring covered by the cling film, it dries up pretty quickly and probably that means that my underwear absorb most of it, instead of my weiner. I don't want this to happen with the $300/mo H-100 gel... I need to find a better way...

Freemason · « **Reply #129 on:** March 23, 2018, 12:39:53 PM »

Pey ron....outermost layer of our dick is extremely thin and highly absorbable..it is the inner layers that stuff cannot really penetrate well. My point is when i get it im just going to use as directed and see what happens. Guess i dont know how long it takes to dry after application. Just dont put on underwear directly after applying...you might have to wait 5-10 minutes.

pey ron · « **Reply #130 on:** March 24, 2018, 12:14:09 AM »

Quote from: Freemason on March 23, 2018, 12:39:53 PM

outermost layer of our dick is extremely thin and highly absorbable..it is the inner layers that stuff cannot really penetrate well

That's what makes me skeptical it's gonna work for me. I have scarring of the septum. All along the septum. These topicals (both H-100 and the diclofenac gel) may work best for people that have a sharp bend or a dent. Those people must have scarring on the "outside" part of the tunica. I have scarring on the "inside" part of the tunica. That's also probably why doctors don't want to do injections on me: the curve is not very sharp and there's a lot of healthy tissue that could be damaged between the "entry points" of the needle and the target scar tissue. I think I am a tad out of luck...

skunkworks · « **Reply #131 on:** March 24, 2018, 12:33:10 AM »

Yeah it is a pretty safe bet that my scarring is septal also.

I have been looking at this cream/lotion and I think improvements could be made. One thing is emu oil actually inhibits 5 alpha reductase, an enzyme which converts testosterone into the far more potent dihydrotestosterone. I do not think inhibition of 5ar enzyme types is a good idea in the penis.

Penetration could be improved either with msm (cheap) or mayb some of the newer and more high tech transdermal penetration enhancers, I'd have to read up on what is available now.

pey ron · « **Reply #132 on:** March 24, 2018, 02:13:06 AM »

Quote from: skunkworks on March 24, 2018, 12:33:10 AM

Yeah it is a pretty safe bet that my scarring is septal also.

Haven't you had it checked via ultrasound?

Quote from: skunkworks on March 24, 2018, 12:33:10 AM

emu oil actually inhibits 5 alpha reductase

I wouldn't say "actually"... it's a conjecture by folks that purport it as a hair loss topical. No-one has had success with it, AFAIK, so I really doubt it is a 5ar inhibitor.

Quote from: skunkworks on March 24, 2018, 12:33:10 AM

Penetration could be improved

they use lyposomal encapsulation... I believe it'd be hard to beat that...

skunkworks · « **Reply #133 on:** March 24, 2018, 09:17:03 AM »

Quote from: pey ron on March 24, 2018, 02:13:06 AM

I wouldn't say "actually"... it's a conjecture by folks that purport it as a hair loss topical. No-one has had success with it, AFAIK, so I really doubt it is a 5ar inhibitor.

I would say actually.

https://www.ncbi.nlm.nih.gov/pubmed/1637346

https://www.ncbi.nlm.nih.gov/pubmed/3260860

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132824/

https://www.ncbi.nlm.nih.gov/pubmed/19353546

NB.

Composition (%) of Fatty Acids from the Emu Oil
Fatty Acid

Oleic 47.4%
Linoleic 15.2%
Linolenic 0.9%

Quote

they use lyposomal encapsulation... I believe it'd be hard to beat that...

Emu oil is a penetration enhancer, msm is as good or better. Removing emu oil (and one should) would possibly require the addition of a different penetration enhancer to make sure the active ingredient achieves the same penetration as with emu oil. Re liposomal encapsulation, how are people who are getting this made at compounding pharmacies achieving that? Can compounding pharmacies do that now?

Re ultrasound, results were inconclusive twice and I had zero luck finding anyone experienced with Peyronie's anywhere near me. Pretty common sadly.

Re merging threads, will do so as soon as I have time to check that it won't screw up flow of questions/answers etc.

pey ron · « **Reply #134 on:** March 24, 2018, 02:51:58 PM »

Quote from: skunkworks on March 24, 2018, 09:17:03 AM

I would say actually

I stand corrected. Sorry, I've seen so many random claims in the hairloss community about this or that natural compound being anti-5ar I was assuming this was yet one of those claims going around...

Quote from: skunkworks on March 24, 2018, 09:17:03 AM

Emu oil is a penetration enhancer, msm is as good or better.

I tried adding MSM to hairloss topicals before and had the *impression* -there's nothing scientific about this observation of mine- it was making them very similar to those with the addition of DMSO... which makes me wonder: will adding MSM cause the vehicle to become a harsh solvent?

Quote from: skunkworks on March 24, 2018, 09:17:03 AM

Re liposomal encapsulation, how are people who are getting this made at compounding pharmacies achieving that? Can compounding pharmacies do that now?

They aren't. One could try at home with an ultrasonic cleaner and lecithin granules. See "recipes" floating around the internet about liposomal vitamin C.

Quote from: skunkworks on March 24, 2018, 09:17:03 AM

Re merging threads, will do so as soon as I have time to check that it won't screw up flow of questions/answers etc.

thanks, but it looks like @LWillisjr has already done that and was able to preserve the order...

skunkworks · « **Reply #135 on:** March 24, 2018, 09:50:40 PM »

Re MSM, I have used it at a high % in topical solutions before with zero issues from skin irritation. Is that what you'd be worried about with MSM? Obv n=1 is not of much use but from doing some reading about it I have not come across much mention of skin irritation.

pey ron · « **Reply #136 on:** March 24, 2018, 10:32:53 PM »

I'm more worried that it may bring in bacteria a la DMSO, or that it may partially melt the cling film I wrap around my penis and bring some of the plastic in... who knows? is there any expert here?

diehardpatriot · « **Reply #137 on:** March 25, 2018, 12:23:14 PM »

My doc sent the RX on Friday. I’m guessing hybrid medical will call me for billing? I’m gonna call Monday if I don’t receive a call by noon

x2 · « **Reply #138 on:** March 26, 2018, 09:07:04 PM »

Could you folks clarify please?

"Scar tissue in septum "-- septum is the tissue in between of the 2 corpora (or the two chambers of the penis). It looks like a "T" that separates the corpora on either side.

The scar tissue or the Peyronie's plaque is usually on dorsal, meaning on top of the septum (upward curvature), or, on either side of the corpora ( left or right curve) or on the bottom (downward curve). Can the scar be on the septum itself?

I have a 30+ degree upward curvature. My plaque is a cord like structure that covers the entire dorsal. Feels like the scar is on top of the "T" , the septum. Does it mean that it is "scar tissue in septum"?

I hope the H-100 can help me, but if it is considered "scar in septum", it sounds unlikely.

Thank you!

TonySa · « **Reply #139 on:** March 26, 2018, 10:21:56 PM »

With upward curve you have plaque on the upper/dorsal side of the shaft—may be septal as well. If going to help should do so with upward curve.

pey ron · « **Reply #140 on:** March 27, 2018, 01:33:20 AM »

x2: we are on the same boat... I have upward curvature with a slight twist. Septal scar, feels hard on the dorsal side, but only when erect. Feels very soft and rubbery when flaccid.

JustAnotherMember · « **Reply #141 on:** March 29, 2018, 07:16:27 AM »

Just so others can see this. I contacted Polymun the company who create the liSOD to see if personal purchase available and they replied with "Unfortunately liposomal Dismutase is not available for purchase.". I know it was a long shot but at least there is a concrete answer.

Link to commercial site deleted by moderator

If anyone uses Hybrid H-100 if they could keep up updated on progress I (as I'm sure others) would greatly appreciate it.

diehardpatriot · « **Reply #142 on:** March 29, 2018, 02:01:34 PM »

My rx is filled. The pharmacy said they won’t be shipping out till late April. They’re short on one of the ingredients . So I’m guessing it’ll be early May when I receive it. When I do I’ll keep everyone updated with any improvement or lack of improvement

Paolo · « **Reply #143 on:** March 29, 2018, 02:11:55 PM »

Great, so we should know by October if H-100 is beneficial along with stretching with some honest reviews and testimonials

diehardpatriot · « **Reply #144 on:** March 29, 2018, 02:59:23 PM »

Yeah . I wish the people in the trial were forum visitors. Seems weird that not one of them visits here. For xiaflex trials many were on here and I’m hoping some forum members get picked for dr Atala’s Tunica and corpora replacement. I’m not sure how much stretching I’m going to be able to get done as I have a new lump I just got 2 weeks ago that’s pretty tender and causes erect pain. That’s my 3rd plaque site already... I’m hoping the H100 reduces the pain and maybe can get the lump to go down and prevent it from causing any new deformity. That’ll make it 1,000 percent worth the money. I can live with the 10 up/ 20 right curve I have already. I’m hopimg by September/October I have good news for myself and everyone else. It seems I’d be 1/3 people who will have the cream ASAP

curved · « **Reply #145 on:** March 29, 2018, 04:22:32 PM »

My dr signed off on the script today as well, and it has been sent to Hybrid Medical. I imagine the timing of delivery for me will be similar to diehard. I will keep everyone posted on delivery as well as progress reports throughout

Freemason · « **Reply #146 on:** March 29, 2018, 08:23:20 PM »

I have an Appt. with Dr. Tidwell in few weeks...FYI..I’ll be up there on business anyway.

So i’ll Get my RX from him...Hopefully

..lol.

I’ll come back and see what info he can provide me as well.

x2 · « **Reply #147 on:** April 04, 2018, 12:25:34 AM »

Quote from: pey ron on March 27, 2018, 01:33:20 AM

x2: we are on the same boat... I have upward curvature with a slight twist. Septal scar, feels hard on the dorsal side, but only when erect. Feels very soft and rubbery when flaccid.

Pey ron,
Thank you for the info. From Dr. Levine's book on Peyronie's, he indicated that the cord like plaques meant mild cases. However, it is troubling me a lot since I was diagnosed 5 years ago. I do hope H-100 will be available and helpful to us. I have had Xiaflex - it reduced to 32 degrees upward from 42 degrees. My uro told me that there is nothing else he could do for me.

TonySa · « **Reply #148 on:** April 12, 2018, 03:15:02 PM »

I’m being told the H-100 is still not yet available, expected end of month. Quoted $270/month if ordering 3 month supply. I wish someone could get the formulation so we could order it from any compounding pharmacy, probably at a lower price.

pey ron · « **Reply #149 on:** April 12, 2018, 06:24:01 PM »

I had been told it was expected for mid April...

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