Erectile Dysfunction

[newguy]

How come no one answers my question?

Are you able to achieve erections at all? I read through a few of your posts and you mentioned that viagra does not work for you? If it has been confirmed that you have calcifications (it seems that it has from your previous messages) then I would think that it due ot peyronie's. You should get on pentoxifylline if possible.

[Noway]

How come no one answers my question?

[Noway]

They say my penial brachies are within limits however it is noted there slightly increased which would be keeping with possible medial wall calcification of the penile vessels. From a vascular laboratory. Does this mean I do have peyronies since its calcified lumps or can it be something different? I noticed a lump on the left side and the underside of my penis and they seem to connect to eachother. The both lumps are both in the middle. Like one is middle bottom and the other one is middle left. Can someone tells me what this means and if it is something different then peyronies disease. Maybe the lumps are blocking the blood flow?

[jackp]

Overcomer

With testosterone (T) replacement you will get a boost in most of areas you  complain about including ED.

Over a period of 4 - 6 weeks as your body gets used to the new T levels all the good benefits remain except for ED. I thought at first I have found a cure for ED but the effects faded rather quickly.

Dr. Abe Morgentaler has a good book called Testosterone For Life that will help you understand T treatment.

Hope this helps.

Jackp

[Overcomer]

peace forever and always brothers, i've joined the ed club too. at first it was just the peyronies but over time it spiraled into full blown ed. i have troubles getting and maintaining an erection and ejaculating really quickly now without much stimulation and dribbling after I finished urinating. the last two happening only within the past year or so. i have since then found out i have low testosterone (ahh). i visited a good doctor and he made no bones about it, i have to go on T Theraphy or....suffer! do you guys think being put on t should eleviate most of these these problems? i suspect it's the main culprit as my T levels have waned the past few years. all this happened progressively.

[jackp]

Cialis is offering a free months supply of daily Cialis or 3 36 hour Cialis.

The coupon was in my newspaper Tuesday or you can also print out the coupon at cialis.com.

You still need a prescription. Read the ad/coupon for details.

Jackp

[status]

Anyone know a good cheap place to get legit and effect cialis, viagra and levitra?

[slowandsteady]

Ocelot556, I've just about eliminated my pain with curcumin (I mix 1.8g with olive oil, take it in the morning, and I'm good all day). It seems to me that getting rid of the pain due to inflammation should be your first step -- that pain really sucks.

I'd be interested in hearing how the pycnogenol (100mg)/arginine (2g) combo (empty stomach on waking) compares to viagra. Pyc and arginine eliminate (mild) ED for me, but I've never tried viagra so I can't compare.

[ocelot556]

I have the same thing, Hornman. Viagra and Cialis have a certain "numbing" effect on my penis, which can make things bad considering that I'm numb enough with the plaques! However, within a day or so of taking it my sensitivity is back to normal, it's usually just the night I've taken it that I feel that numbness. Peyronies Disease can itself cause numbness, as reported by myself and other users.

[Hawk]

Cialis always causes me significant delayed onset back pain.  Out of the main 3, Levitra is my preference.

[hornman]

Has any one else noticed a lack of sexual feeling in their penis during sex?  With the help of 1/2 cialis I can sustain a good erection but I can't feel a thing.  I also have great difficulty reaching orgasm.  I don't think the cialis is causing the lack of feeling because its there even when I havn't taken it. I am getting some bad side effects from the cialis for sure.  The day after I feel headachy and hung over with a dry mouth and some back pain. I would really like to get some feeling back!

[Nemo]

I've seens references online that indicate that in the past, Pentox was used to some degree as a treatment for ED.  However, the PDE-5 inhibitors like Viagra, Cialis, Levitra came along and eclipsed it totally in that regard, so I doubt if anyone is prescribing it for that purpose anymore. 

Nemo

[newguy]

Has anyone tried Pentoxiphilline for ED? What was the result?

You likely mean "pentoxifylline" (aka Trental). It may help with ED to some extent though there are many other reasons why people take it for peyronie's. It's likely the most talked about oral treatment here, so I recommend doing a search.

[pichou]

Has anyone tried Pentoxiphilline for ED? What was the result?

[astyanax]

PS six months waiting is really abnormal. Usually those guys have 'more practices'. When you book them by hospital, weighting periods are often a lot longer. Maybe you have to find out if you cannot schedule an appointment with him through another route, his private practice for instance.

Well, in Canada I don't think there is another route.  I called his office, I was told 'it does take around 6 months to see him'.  I got put on a list for cancellations nearly 2 months ago, but still nothing...  I suppose people that have to wait 6 months aren't going to cancel the appointment no matter what.

[Pete28]

Astanyx


I understand your situation and feeling very good.

I'm also in sortalike condition.

Very difficult, nearly impossible to get erect. I've the feeling ALL my penis is becoming one big scar.
Each time i masturbate erections become more difficult and painful.

I had a Doppler (when flaccid) on saturday, but doc again says there is no fibrosis. That's not what i feel.

I feel abandonned and restless.

PS six months waiting is really abnormal. Usually those guys have 'more practices'. When you book them by hospital, weighting periods are often a lot longer. Maybe you have to find out if you cannot schedule an appointment with him through another route, his private practice for instance.

[astyanax]

Apologize, my post below is a bit of a mess.  Had a few drinks before writing it, going to clean it up.

The reason I waited so long, is because it's just so damned embarrassing (rather, when you're a teenager it is).

I was diagnosed by a urologist, my family doctor has told me in the past that it's just all in my head, etc etc.

Apparently this doctor specializes in doing surgeries in that area, he's highly regarded in the field.  Just wish it wasn't a 6 month wait to see the guy, this has been really, really, driving me up the wall lately.

[lwillisjr]

I really need to cry my heart out to some anonymous strangers that pay the same bill as I.

When I was 10/11 I smashed my unit hard up against my jeans when my mother burst into a room, suffice to say I was playing with it.  I actually suffered bleeding afterwords out of it, I kept it to myself, and SEVERE pain.

Had a colonoscopy done, everything's in fine order.

edit;  told me i had peyronie's disease.

astyanax,
Many here are more than willing to listen and offer advice. Sounds like you are asking a couple of different questions. The main one seems how a young man of your age deals with this with relationships. Some of the younger guys on the forum will have to help with that.

At the bottom of your note was an edit that didn't makes sense. Who diagnosed you with Peyronies Disease? If this was your general practice doc, then he might suspect Peyronies, but you need to get it properly diagnosed. The fact you said there was blood when the injury occurred concerns me. You possibly could have some other damage or injury far beyond Peyronies Disease.

You referenced a colonoscopy. These are good for colon examinations, but would tell you nothing that I can think of regarding penile condition or health. Bottom line is that I think you want to get this diagnosed and FIXED if possible. So would encourage to keep your appointment with your specialist. Is this an urologist the specializes in Peyronies Disease, or a sexual specialist?

Why did you wait until the age of 25 to get this examined/fixed.

[astyanax]

Hi guys, first time poster.

I really need to cry my heart out to some anonymous strangers that pay the same bill as I.

When I was 10/11, I was in a big hurry to get my jeans on, and bent it in a real bad way.  I actually suffered bleeding afterwords out of it, I kept it to myself, and SEVERE pain.

I'm 25 now.

My unit 'tries' to go up, but it wont.  It's numb even.  Particularly before the part that i can literally bend is much harder than the rest of it.  I have bleeding on my otherside also,(VERY hard to describe the area), which i've even had a proctologist check, and a dermatologist.  Had a colonoscopy done, everything's in fine order.  They can't figure out what it is, but I'm positive this started happening shortly after I hurt myself.

I've mentioned this to my doctor before, and again, and again.  Finally got a referral to a doctor who, at first prescribed me viagra, that didn't work, went back again and saw him, told him the same symptoms, he's sending me to London ONT to see a doctor Brock, who's apparently top notch in this field.  I get to wait 6 MONTHS before I can see him.

This has taken a toll on me so bad, it's ridiculous.  I sort of just put in the back of my head all this time, putting it off, just extremely nervous / embarassed about it.

Are there any younger guys out there dealing with this?

[Angus]

Pete, here's an idea that worked years ago for me. Buy a hand held electric vibrator, the kind intended for muscle relaxation, stress and so forth. You can find them at drug stores and online and they don't cost a fortune. Im not talking about sex store vibrators. Some have interchangeable heads. Use the head that is the most rounded and use that for stimulation. Don't push too hard and don't rub it back and forth; it's not necessary. It may take 10 or more minutes to get an erection; other days it will happen faster. This will get erections without hand stimulation and the worry, skin abrasion and swelling that comes from too much hand stimulation. It takes a little getting used to, but trust me, it works.

[Pete28]

Can excessive masturbation friction induce fibrosis?

The only way to get erect is by long self stimulation. I try to do this very carefully. But the underside of my penis starts to harden. I first have to force the blood past 'the fibrotic hardering' at the base before being able to become erect. It also hurts a bit (friction). I have to stimulate for about fifteen minutes (with Cialis) to induce 'full erection'. Constant stimulation is needed, can maintain erection when lying on back, i also loose erection when standing.

I masturbated very long on Saturday because i wanted to test if i could still manage it. Now the underside of my penis starts to harden. Can fibrosis develop that quickly?

What should i do, give it a rest for a while and onely use VED?
The forcing of blood past fibrosis, does it induce more fibrosis?

I just dont know what to do NOT to improve the situation but to not make it worse: rest? (but lack of blood flow and movemant can cause fibrosis) or stimulation (friction also causes fibrosis).


Any opinion or advice would be very appreciated because i have a very serious problem here and can onely visit my uro within a month.

[ocelot556]

I have the same problem sometimes, RichB. Remember though, unless there is fibrosis in the corpora your venous leak can be resolved. By shrinking the plaques you can increase the amount of pressure on the circulatory system of the penis, thus maintaining longer erections. If it's even venous leak, I don't know -- I have a similar problem, where it seems like I can feel the blood leaving just one side of my penis, where the majority of my scars are.

Also, when I was a kid I could walk around with my hardon waving in front of me, leading the way - now, unless I'm getting direct stimulation (physical or visual) it goes away. This might be a symptom of age, since I manifested Peyronies Disease at 22 and am 25 now and I'm aware that a man's sexual peak occurs at 21. I've just started the VED this week, and it seems that I get a much stronger and fuller erection after using it (I'm not using constriction bands, either).

Also remember, if you get anxious or nervous your body will release adrenalin, which is an erection killer. I fall into that trap sometimes, getting panicked about not being fully hard, then not being able to get fully hard and not knowing if it's physical or if it's because I was worrying about it so much that my nerves got the better of me!

[RichB]

Well, it might just be because I am experiencing new pains, but starting somewhere around the beginning of last week, every time I get an erection I feel the blood sort of just rushing back out from where it came. Also, the erections do not feel the same as they used to. It might just be my anxiety or something like that, but things do seem to have changed. It's hard to pinpoint. I can get an erection fine, keeping it is the problem. I can't just "sit" with it if you know what I'm saying. But I haven't really been able to do that since the onset of Peyronies Disease symptoms. Things just seem generally worse lately. I thought it was the anxiety of my exams at school, but things seems to have stayed since school let out.

I felt like this before when my Peyronies Disease started, and I recovered without any ED. I am not sure of the outcome this time.

EDIT: I know that venous leakage does not occur simply overnight, but over a period of time. It's been about 4-5 months since my Peyronies Disease showed up (wow time flies), and I am unsure of the progression. I know that at least two weeks ago things seemed to be improving. It might just be in my head. But I am unsure.

[lwillisjr]

I think I may be beginning to develop venous leak. This is very disheartening. It seemed to come out of nowhere.

Richb,
What are the symptoms you are experiencing that leads you to think venous leakage? I'm just curious as I have no idea what the symptoms are.

[lwillisjr]

Am I the only guy around that gets the listed side effect of delayed back pain?

I have used all 3 but due to the back backpain from Cialis, and the need to avoid food with Viagra, I opt for Levitra.

Hawk,
I've tried both Viagra and Cialis. No side effects with either one.  sorry 

[RichB]

I think I may be beginning to develop venous leak. This is very disheartening. It seemed to come out of nowhere.

[Hawk]

Am I the only guy around that gets the listed side effect of delayed back pain?

I have used all 3 but due to the back backpain from Cialis, and the need to avoid food with Viagra, I opt for Levitra.

[Jackieo]

Cowboy and all:
My two-cents...I have experimented with both Cialis and Viagra over the past few years (following a difficult surgery).  The two different pills are both easily cut into halves or quarters with a cheap over-the-counter pill cutter (the shape of Cialis makes it hard to judge cutting equal portions when you are trying for four equal quarters).  Viagra caused me to flush (...I thought I was experiencing male menopause), congestion, and made my heart to race.  The Cialis is a dependable ready-when-U-R solution without those side effects (for me)....I read a post by Tim468 that he had nasal congestion from the Cialis.
Like all these drugs... I think you need to find a good level for yourself and keep to a uniform schedule.  I was originally using Cialis for "sex" and it caused me rushes....not the case now that I am using the minimum daily dose.  Start with a smaller dosage and build-up.
JackieO

[cowboyfood]

cowboyfood,

Cialis works over a longer period of time. Not sure why the uro recomended the Cialis over Viagra. With Viagra you have to do a little more "planning" for sex. I've had Cialis and Viagra. Both have the same positive effect for me, but the Cialis does seem to last longer. The viagra is not easy to break into 4 pieces.

lwillisjr,

Actually, the uro (the second one) suggested the Viagra over the Cialis.  I can't remember why (my bad).  The first uro I saw gave me a prescription for viagra, cialis, and levitra, and did not elaborate on which to use.  So, I just took a "stab" at cialis. 

But, I think I'll try the Viagra...and, yes I've read on here that it is a challenge to cut the 100mg into 4 pieces.  But, someone suggested that had some success with a pill cutter they bought.

CF

[Tim468]

I dropped the HGW for routine use of Cialis. IT does a better job of making me eternally ready, but slightly more side effects of nasal congestion. I take only about 5 mg every other day - a low dose.

Tim

[lwillisjr]

cowboyfood,

Cialis works over a longer period of time. Not sure why the uro recomended the Cialis over Viagra. With Viagra you have to do a little more "planning" for sex. I've had Cialis and Viagra. Both have the same positive effect for me, but the Cialis does seem to last longer. The viagra is not easy to break into 4 pieces.

[cowboyfood]

richb,

I just filled a prescription at CVS for three 20mg tablets for $58.

I've been cutting them in half and taking one of the halves every other day. 

However, the uro I saw yesterday suggested I try Viagra; he wrote me a prescription for 100mg pills and he wants me to cut them into 4 pieces; then take one of the pieces on a daily basis.  But, I'm not sure of the cost.

Also, I believe Tim suggested using Horny Goat Weed in place of Viagra because it has the same "ingredient" that makes Viagra effective (search for his post, I don't have it handy); and, I believe the HGW route is substantially less expensive than Viagra.

I've never used Cialis (or anything similar) until a couple of weeks ago.  It worked and help get me through a psychological rough spot I was going through.

CF

[RichB]

How much does Cialis cost on average per month?

[ocelot556]

I'm the same way, Bongo, but my reward will not have to expect every time I can't get hard for any reason whatsoever that this is the first time for the rest of my life that I've got full ED. It's that doubt that's the worst damn part of ED. Before I had peyronie's if I didn't get hard, oh well, there's always tomorrow. I'll get some sleep, or eat something, or try again in an hour. I have a dullness of sensation because of the pain I had for so long, too, or maybe because the scars are depressing nerves - I don't know, though the pain isn't almost ever there anymore.

Also, for those of you who experience ED from this - sometimes it feels as if I can feel the blood draining out of the side of my penis that is more scarred - of course it always causes me to panic and lose my erection, so I can't tell if I'd lose the damn thing anyway. Is this a common feeling? Or maybe me overthinking an uncomfortable feeling?

[Bongo]

Hawk,

Your explanation to erectile difficulty in Peyronies makes so much sense in my case. I am now waiting to start VED theraphy. Hopefully, I can manipulate some of the scarring positively in the course of time, which will allow my veins to contrict naturally. I do not have a clue where the scares are located, so I can only speculate.

Thanks - no doctor of mine has ever talked about any possible explanation to my ED. They simply tell me to use Viagra - "all your problems will be solved young man".

I have found absteining from masturbation, heat treatment and drinking alcohol to help with the ED and reduce the pain ("somewhat normalised erectile function", although as of yet with no spontanious erections). But as soon as I masturbate, I am more or less back to square one with ED and pain.

My penis is also not very sensitive anymore after 5 years with this disease. The day where I will have a spontanious, unpainful erection again will definitely mark a breakthrough for me.

[voulezvous]

I know that in my dealing with this condition my view of sex has changed immensely. It honestly doesn't seem as fun and care-free as it did before. I know that will change in time, but right now my views of sex have definitely changed in a big way.

richB

I suppose because of my age I am a rare situation but I want to respond to your post. I spent the 1st 60 years of my life with the "fun & care-free" feeling you mention as well. More to the point, without being aware of it, I was always confident to a fault & it affected my disregard for women's feelings. I used sex as a tool to build my ego. Then came the crash. I have been humbled & I will never take any level of sex for granted again. Truthfully, Peyronies Disease helped to make a better man of me because I learned 2 very big lessons: I am much more than my sexual ability and women (God bless 'em) are no where nearly as concerned about what is between your legs as I used to think. No, you will probably never be quite the same, physically or mentally, but, if you dig deep, you will find that life is still very, very good & you can find ways to use this trial to grow as a man.

[RichB]

I know that in my dealing with this condition my view of sex has changed immensely. It honestly doesn't seem as fun and care-free as it did before. I know that will change in time, but right now my views of sex have definitely changed in a big way.

[voulezvous]

Maybe I was too extreme in my warning. I only meant to suggest that there are people on this forum who have had bad expeiences with injections. Not that it is "high risk." There's some risk involved in any procedure. At some point you either have to roll the dice a little & trust or you may not find any answers. Ultimately, its your decision.

How do you mean? There are a lot of 1 shot = permanent damage cases?

Then why is it performed in hospital if the risk it that high?

Bluth:

Its difficult to make a case for injections because there is ALWAYS a risk. Many on this forum swear they will never allow another because of damage they had done whether by chance or just poor work by a urologist. Personally, I have been getting verapamil injections on a 8-week basis for about 2 years & have never had a problem-even with bruising. Its no picnic but, assuming you have a competent urologist, I would not refuse the injection if he/she thinks it is in order. I believe the odds are in your favor-especially if it is just once.

[newguy]

I'm not saying there isn't some indirect link between Peyronies Disease and ED, but I haven't figured out the physics of penile mechanics of this yet. And my point is that we all need to realize there is a bigger psychological component at play here that we may not realize or choose to ignore.   

I think it's risky to go all of nothing with any statement, so that's why I included the "probably" comment really. I do agree though that I can see how dealing with peyronie's can impact our attitude towards sex, our image of ourselves and so on. Since peyronies tends to manifest itself once an erection is achieved, I can certainly see how on a conscious or unconscious level, there can be an element of fear attached to achieving an erection, because we never quite know what we're going to be presented with. It is a heavy load to carry. I myself thought that I can coping very well, but a few days back I had something I'd only be able to describe as a slight panic attack -something I've never before experienced. Very strange. It's no doubt often hard to gauge our own experience until we find ourselves in a different state of mind.

Again though, I do think that ED is sometimes linked to both the mental side or things, and peyronie's disease itself. I should think there is quite a spread of people with ED for one reason, the other, or both.

[Pete28]

How do you mean? There are a lot of 1 shot = permanent damage cases?

Then why is it performed in hospital if the risk it that high?

Bluth:

Its difficult to make a case for injections because there is ALWAYS a risk. Many on this forum swear they will never allow another because of damage they had done whether by chance or just poor work by a urologist. Personally, I have been getting verapamil injections on a 8-week basis for about 2 years & have never had a problem-even with bruising. Its no picnic but, assuming you have a competent urologist, I would not refuse the injection if he/she thinks it is in order. I believe the odds are in your favor-especially if it is just once.

[jackp]

bluth

The injections I advise against are PGE1 and/or trimix for ED. These injections over time can cause corporal fibrosis. I tried them for about a year and made my corporal fibrosis worse.

An injection in the doctors office by a doctor should not cause any problems.

Jackp

[voulezvous]

Bluth:

Its difficult to make a case for injections because there is ALWAYS a risk. Many on this forum swear they will never allow another because of damage they had done whether by chance or just poor work by a urologist. Personally, I have been getting verapamil injections on a 8-week basis for about 2 years & have never had a problem-even with bruising. Its no picnic but, assuming you have a competent urologist, I would not refuse the injection if he/she thinks it is in order. I believe the odds are in your favor-especially if it is just once.

[bluth]

Should I refuse an injection if my urologist wants to give me one to induce an erection and measure the degree of curvature in my penis?

I've read that people have advised against getting injections before and wanted to see people's thoughts before I visit my urologist today.

I have no trouble getting erections otherwise without any sort of ring or pills.

Thanks

[Pete28]

It may depend on which site of the tunica and/or cavernosal bodies fibrotic changes occur and how 'big' the plaque is.
It's is well know that fibrotic changes in the penis can leave a pattern that is consistent with veno-occlusive dysfunction.
It occurs quite often, but not allways. The aswer to that i don't know. But it's the same question as why some people survive cancers and others not, why some people can run marathons below 3 hours and others not. I believe gene factors play a key role. Within a hundred years from now, i'm sure science will be able to explain a lot more.

[/quote]

Sorry to disagree.

My understanding is that both the arteries and veins involved during an ereciton are below the tunica. Yes the arteries are deeper but all are beneath the tunica. By definition Peyronies Disease is scarring on the tunica. So I'm struggling with the physcial connection between Peyronies Disease and ED. Let's not forget that many with Peyronies Disease don't have any ED problems. I don't want anyone to think that if they get Peyronies Disease, that it automatically implies ED.
[/quote]

[lwillisjr]

lwillisjr - I do that that there is a often link between ED and peyronie's. I suppose it could be argued that the number of peyronie's suffering being of a certain age, but even the younger members here often suffer from ED. There's probably a psychological component to that, but I'd be surprised if that explained all of what is occuring. Peyronies Disease is scarring, yes, but there is assumption being made that no damage at all occurs elsewhere. I'm sure there are multiple elements relating to this disorder that we are not fully aware of at this time.

Newguy,
I think we owe it to our fellow sufferers here that we need to change our way of thinking. Instead of of thinking that there is "probably a psychological component", we need to point out that there IS a psychological component. When I first developed Peyronies I was sure I was psychologically handling it fine. It took my wife to help me understand that it was affecting me mentally and physically. As men, all of us at one time focus on the way our penis looks, feels, the size, sensation, ability to achieve orgasm on command, etc.  So when just one of these aspects changes it does impact us in some way. I was getting to where I was losing my interest in sex and didn't realize it. The frequency of sex slowly decreased and I didn't notice it. I was mentally slipping in to a new "comfort area" for me. No sex meant I didn't have to face my deformity or try to find new positions. Under regular circumstances I'm all for finding new positions, but not when it is because the current way is uncomfortable or isn't working.

I'm not saying there isn't some indirect link between Peyronies Disease and ED, but I haven't figured out the physics of penile mechanics of this yet. And my point is that we all need to realize there is a bigger psychological component at play here that we may not realize or choose to ignore.   

[newguy]

lwillisjr - I do that that there is a often link between ED and peyronie's. I suppose it could be argued that the number of peyronie's suffering being of a certain age, but even the younger members here often suffer from ED. There's probably a psychological component to that, but I'd be surprised if that explained all of what is occuring. Peyronies Disease is scarring, yes, but there is assumption being made that no damage at all occurs elsewhere. I'm sure there are multiple elements relating to this disorder that we are not fully aware of at this time.

[lwillisjr]

I speculate the other cause is physical in that the location of plaque is positioned so it prevents a major vein from being squeezed or constricted.  In other words the plaque holds the constricting force off of the vein.  This allows the vein to drain blood at a faster rate.

So theoretically, by stretching fibrotic tissue (if possible) the veins could regain there ability to prevent blood outflow and thereby a solid erection would be regained?

Sorry to disagree.

My understanding is that both the arteries and veins involved during an ereciton are below the tunica. Yes the arteries are deeper but all are beneath the tunica. By definition Peyronies Disease is scarring on the tunica. So I'm struggling with the physcial connection between Peyronies Disease and ED. Let's not forget that many with Peyronies Disease don't have any ED problems. I don't want anyone to think that if they get Peyronies Disease, that it automatically implies ED.

[Pete28]

I speculate the other cause is physical in that the location of plaque is positioned so it prevents a major vein from being squeezed or constricted.  In other words the plaque holds the constricting force off of the vein.  This allows the vein to drain blood at a faster rate.

So theoretically, by stretching fibrotic tissue (if possible) the veins could regain there ability to prevent blood outflow and thereby a solid erection would be regained?

[Hawk]

I have never heard a doctor give a thorough explanation of the mechanics of Peyronies Disease related ED. 

Erections result from nerve centers transmitting the message for the release of nitric oxide (NO) in the walls of the penis arteries.  These arteries lie deep in the penis.  The NO causes the arteries to relax, dilate, expand.  This dilation allows and increased volume on blood flowing into the penis.  The rate is faster than the rate at which the veins allow the blood to flow out causing the penis to fill and expand.  Incidentally, the veins lie close to the surface of the penis.  This is kind of a chain reaction since an erect penis tends to squeeze and constrict the veins and this slows the volume of blood the veins can remove from the penis even more.

It is mostly my speculation but I think that Peyronies Disease causes ED in 2 ways.  One is stress of the disease that cause adrenalin to attach to the NO receptors and prevent the NO from dilating the arteries. I guess it is also possible that Peyronies Disease could cause distraction from psychological stimulation and even prevent the release of NO.  In either of these cases, one would likely still get night-time erections (NTE).

I speculate the other cause is physical in that the location of plaque is positioned so it prevents a major vein from being squeezed or constricted.  In other words the plaque holds the constricting force off of the vein.  This allows the vein to drain blood at a faster rate.

The problem is that al this is interrelated.  As soon as a guy sees his penis is not as hard as it should be he begins to stress or experience anxiety which releases adrenalin.  The adrenalin prevents the NO from dilating the arteries and now he has a mixed case of physical and psychological issues impacting his erection.

Since the veins are closer to the surface, the problem of veins transporting too much blood out of the penis can be helped with a constriction band like the adjustable Actis Loop.

Until someone finds (or comes up with) a better explanation, this one is the only thing that makes sense to me.

These illustrations my help.  http://www.peyroniesforum.net/index.php/topic,106.0.html

[Pete28]

Does anybody know what's the exact 'scientific' explaination that, while having a large curve in your penis, this affects the hardness and maintainance of the erection? I have significant bend but there is no pain whatsoever when erect.
Apparently there is a direct correlation. Because i have read some with some guys who have been able to straigthen the curve, the erectile riability also came back.