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Author Topic: Tissue Engineering  (Read 45845 times)

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edzo67

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Re: Tissue Engineering
« Reply #50 on: November 02, 2014, 01:00:42 AM »

When I first heard about this about a year ago, I sent them an email volunteering for any human trials when the time comes.
The following day I received a phone call from the Dr's assistant and she asked me for my backround with Peyronies disease and told me that they would add me to their list of potential candidates for trials. They are doing wonderful work. I hope they come up with a positive solution in my lifetime. Knowing that they are hard at work to help people with severe penial injuries gives me some ray of hope and something to keep my chin up. You all can relate to that kind of desperation and the ups and downs of keeping faith. I f I had a million dollars? I would put it into their research....Gladly and without hesitation
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mrg91

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Re: Tissue Engineering
« Reply #51 on: November 02, 2014, 01:55:17 PM »

thank you Mr.edzo67 for answer and i hope like you that in near future they do it and your answer encourage me although i know this medicine search is very complicated and really hard.
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Lollaro

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Re: Tissue Engineering
« Reply #52 on: November 11, 2014, 04:23:50 AM »

I read this post .. is very interesting...

Do you think this could be a way to cure Peyronie's final?
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Jack1909

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Re: Tissue Engineering
« Reply #53 on: February 17, 2015, 05:21:01 AM »

I read a lot about Atala's studies..the most important obstacle to overcome is obtaining FDA's approval to start human trials for lab-grown penises. As far as I know, He already created successfully more than a dozen of human penises...the next step is trials. We are close. He already created and implanted two vaginas in two girls who suffered from a disease that prevented them from growing it. Practically they were without vaginas. Now they live a perfect normal life and they have intercourse with feeling.
About men, He created urethras in some guys who did not have them perfectly grown and it works as our urethra work.
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mrg91

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Re: Tissue Engineering
« Reply #54 on: February 22, 2015, 12:26:25 PM »

drea jack1909.like many of other person at this forum i suffer sever penis injury(not peyronies but nerve and sever b.c muscle injury cause wrong penis pump use). i really have very horrible situation and i lost my hope about every thing.every day i just sit and think about my stupid mistake for making my penis bigger and i cant found anything to calm me down.i contact with wakeheath by email and they told me we are continue our research but they never told me when it will be possible.only at news i see it could be possible near future like 5 years later.i am tired of being waiting since 2 years ago till unknown possible future(that i even dont  know regenerative medicine can solve my problem or not).i really dont know what should i do.. i ever think to total phallo(my penis is now just useful for urination)as i know its not functional and cant solve my physical and psychological problem and its very expensive.if you know something new and hopeful about dr.atala please tell us.thank you my friend.
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james1947

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Re: Tissue Engineering
« Reply #55 on: February 22, 2015, 05:12:19 PM »

mrg91

Can you say more regarding your symptoms?
Did you see already a Peyronies specialist?
Why you think that the only solution for you is Tissue Engineering?
If you will give us some more details regarding your symptoms and what you have done to treat them, other members will be able to give you they opinion.

James
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mrg91

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Re: Tissue Engineering
« Reply #56 on: February 22, 2015, 08:24:19 PM »

hello dear james. ok,please see these addresses(i know its a lot but these describe my problem)
1. Link to commercial site deleted by moderator - James  (this includes another peson and my post that i describe,number8 comment is my describe) 
 2. Link to commercial site deleted by moderator - James 
 3. Link to commercial site deleted by moderator - James 
  in one sentence i suffer sever penis nerve damage and b.c muscle injury.
also another site that i can tell is:
Link to commercial site deleted by moderator - James 
sorry for these lots of sitse but you can read some of them fast and know what is my problem and some others like me.

thank you james for your reply.
   
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james1947

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Re: Tissue Engineering
« Reply #57 on: February 23, 2015, 06:39:45 AM »

mrg91

I asked a few simple questions from you to understand better your problems and the answer was 4 links to commercial site.
And then, reading again all your posts, I found that you had one more link to the same site.
Links to commercial sites are not allowed on this forum, please read the forum rules and obey them!!!


James
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mike jones

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Re: Tissue Engineering
« Reply #58 on: June 10, 2015, 09:12:00 PM »

I was wondering if anyone knows if regenerating the erectile tissue will also mean regenerating the dorsal vein as I am afraid mines might be damaged
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drew67

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Re: Tissue Engineering
« Reply #59 on: June 10, 2015, 10:06:09 PM »

Looks like Atala will be able to replace the fibrous tissue much sooner than the predicted 5 years before they'll be able to replace an entire penis.
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mike jones

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Re: Tissue Engineering
« Reply #60 on: June 11, 2015, 03:21:19 AM »

Dr. Atala said they will perform clinical trials within 5 years. I'm not to sure where but I have read somewhere that they will perform these trials in the summer of 2016. However, even after these trials take place it will be a couple of more years before the treatment will be clinically available.
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Jack1909

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Re: Tissue Engineering
« Reply #61 on: June 11, 2015, 04:01:48 AM »

I can understand that everybody here is focused on Atala's work, probably because no one as him has pronounced about engineering tissues, but, I have to point out that no many in here need a total renew of their penis. And, as Atala told many times, he is working on misses parts to replace rather than fixing them. This what does it means? This means that we should expect to overcome our problems sooner.
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Jack1909

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Re: Tissue Engineering
« Reply #62 on: June 11, 2015, 04:03:11 AM »

I mean, don't forget the old sweet Europe.
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mike jones

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Re: Tissue Engineering
« Reply #63 on: June 11, 2015, 05:09:04 AM »

Yes that it true they might be able to replace the tissue within the next 5 years but it mostly likely won't be widely available until later on. For example they can regenerate bladders however only a hand full of people that needed a bladder transplant actually got a regenerated bladder.
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pfract

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Re: Tissue Engineering
« Reply #64 on: June 11, 2015, 12:59:44 PM »

Mike Jones: but are you sure there is something new on Dr. Atalla? Could you please try to find the link? i thought we still needed to wait 5 years at least....
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mike jones

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Re: Tissue Engineering
« Reply #65 on: June 11, 2015, 03:30:08 PM »

There wasn't a new article what I had saw was a email from  Dr Atala that said they expected the trials to begin in the summer of 2016
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drew67

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Re: Tissue Engineering
« Reply #66 on: July 16, 2015, 09:32:06 PM »

Was in touch with the principal investigator for the Atala trials.  Here is the transcript:

Will you be involved in Dr. Atala’s trials of repairing parts of the penis using the 3D printing technique? 

--

I am the principal investigator on the trials to which you are referring. We won't be using the printed constructs. We will be engineering tissue in decellularized cadaveric tissue. Our first aim is treating wounded soldiers, and later rolling it out to civilians.

--
Would this technique be able to fully repair damaged tissue caused by peyronies or does it depend on the case?  When do you anticipate treating wounded soldiers and how soon after that civilians?

--
Every case is different. We are still working with the U.S. DOD and the FDA on our timeline.
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james1947

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Re: Tissue Engineering
« Reply #67 on: July 16, 2015, 09:44:32 PM »

Thanks for the information Drew.
It seems we are very far from getting something for us :(

James
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drew67

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Re: Tissue Engineering
« Reply #68 on: July 16, 2015, 10:02:59 PM »

So as opposed to replacing parts of the penis using 3D printing the decellularized cadaveric tissue will be used as a scaffold for tissue reconstruction.  I suppose the results must be pretty good or they wouldn't be going forward with this technique.
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Jack1909

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Re: Tissue Engineering
« Reply #69 on: July 17, 2015, 02:53:16 AM »

The results are outstanding as far as I know..this the basement of the regenerative medicine. A scaffold is from where all begins..and let me say that most of people here need just a new tunica so it would be very feasible. I mean..they are about to commence the total replacement trials..at this point we should already have heard about someone with partial replacement.
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kuaka

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Re: Tissue Engineering
« Reply #70 on: July 17, 2015, 09:04:04 AM »

Definitely watch this...and report here.
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pfract

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Re: Tissue Engineering
« Reply #71 on: August 03, 2015, 08:16:17 PM »

thank you for providing us with such an insight on the subject. Although we are super impatient, things "seem" to be heading towards a better understanding of the peyronies disease. Who knows how things will be in 5 years from now? Positive i hope.. :)
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Jack1909

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Re: Tissue Engineering
« Reply #72 on: December 04, 2015, 08:17:14 AM »

Any news from those guys who said they'd have underwent a procedure in Mexico led by Atala's team? I think it was in October..
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krazylord

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Re: Tissue Engineering
« Reply #73 on: December 22, 2015, 01:24:50 AM »

Hi Jack,

I messaged one of them and he didn't reply. Looks like he last connected on Oct 20th. I hope everything went ok for them. I called the Wake Forest Institute and talked to the person in charge of the regenerative medicine department, and they put me on a list, but apparently this list is to regrow penis or parts of the penis. It has nothing to do with stem cell. So I will try to call again and find out who is the doctor involved on this.

After doing some research, I found the name of a professor involved with the stem cell, but I am unsure as if he is a doctor or not. Here is the link: AFIRM: Research Programs: Genitourinary and Lower Abdominal Research Leaders His name is John Jackson.

By the way, I also ask to see Dr. Atala, but apparently he only sees pediatric patients, not adults for Urology issues...
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Jack1909

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Re: Tissue Engineering
« Reply #74 on: December 22, 2015, 11:38:00 AM »

Thank you very much for the reply,
let's hope to have some news in a little time, some update that shows us we are close to something.
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drew67

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pfract

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Re: Tissue Engineering
« Reply #76 on: February 24, 2016, 01:54:23 AM »

"The institute has identified at least 29 tissues and organs for their regenerative potential, some of which they already have had success such as the bladder, ear, penile tissue, skin and vagina"

Thank you so much for sharing this! so much!
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NeoV

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Re: Tissue Engineering
« Reply #77 on: February 24, 2016, 02:59:06 AM »

Very interesting and hopeful indeed.
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Freemason

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Re: Tissue Engineering
« Reply #78 on: February 24, 2016, 09:57:39 PM »

This is truly amazing research...5 years or so fellas...5 years...15-20 years and you can prob forget about worrying about heart disease. This technology will print you a new heart to be transplanted with zero rejection..amazing.
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james1947

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Re: Tissue Engineering
« Reply #79 on: February 25, 2016, 03:35:59 AM »

I suppose that I will not be around 15, 20 years from now, let's hope is not 150, 200 years
Here we are 9 years after the first post on the forum regarding Dr. Atala (September 05, 2007) and we are still in the "HOPE" stage

James
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popopo

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Re: Tissue Engineering
« Reply #80 on: March 04, 2016, 05:51:51 AM »

I agree James, it's all taking way too long. I'm 21 so I have some time left, but even then I can't stand the wait. Are there any updates on Atala, because personally tissue engineering seems the only REAL cure to me. I heard about human trials in the summer of 2016, but I'm not 100 percent sure.
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Jack1909

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Re: Tissue Engineering
« Reply #81 on: March 04, 2016, 08:13:50 AM »

Just consider that most of us in here need ''just'' a tunica replacement and in general a partial replacement. That's get the things easier and closer than having a total penis replaced as all these articles are about. They speak about a total replacement of complex organs.
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james1947

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Re: Tissue Engineering
« Reply #82 on: March 04, 2016, 04:35:08 PM »

I am not talking about penis replacement.
I am talking about "simple parts" replacement.
We are not closer to that than 9 years ago!!!
Sorry sounding so pessimistic, but let's be rational. Sadly, no any advances in the horizon :(
Posting opinions in the media is done for sealing purposes.
Bu it is just my opinion, the future will say if I am wrong.

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
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james1947

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Re: Tissue Engineering
« Reply #83 on: March 12, 2016, 01:37:49 AM »

So now I am optimistic regarding stem cell therapy for restoring vision for blind people.
Miracle cells to cure blindness - CNN.com
No, it is not off topic as it is an example how stem cell therapy going fast forward.
The research started at 1998, trials started in 2015, 17 years of fast track!!!
Still trials, but what a progress for people that yesterday were blind and today can see :)
Hope it will help other researches in the stem cell therapy, including restoring penis tissues :)

James   
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Brunobald

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Re: Tissue Engineering
« Reply #84 on: March 13, 2016, 07:40:27 AM »

I have a feeling stem cell treatment and tissue regeneration will take off very soon. Every bio lab feeds off each other and the progress seems fast. Tunica replacement sounds doable even now.
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Billionaire

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Re: Tissue Engineering
« Reply #85 on: March 16, 2016, 08:45:17 PM »

The basis for all tech, from imaging, to stem cells, to tissue engineering, to robotic surgery is ALL already here.

What holds us back is cultural attitudes towards male sexuality that insist on shame and excessive secrecy.

The disorder know as MRKH in women is pycho-emotionally very similar Peyronie's in that it structurally prevents penetrative sex and limits partner options. They however, have global support groups and non-profits, pull in Washington, media coverage and societal awareness... because they talk about it.

What we need is to ally ourselves with them and others, because as far as tissue engineering and regenerative medicine, the tech solutions are very similar for males, females, intersex, and trans people.

To put it into context, entire vaginas have been grown in labs and implanted already, a far more complex procedure than what most of us need. At this rate, we're going to print entire penises before we master the comparatively small regenerative remodeling of Peyronies Disease scar tissue.

In the advocacy group I've presented one strategy complimentary but different to the mission of this group.

I have a feeling stem cell treatment and tissue regeneration will take off very soon. Every bio lab feeds off each other and the progress seems fast. Tunica replacement sounds doable even now.
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Billionaire

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Re: Tissue Engineering
« Reply #86 on: March 16, 2016, 08:51:05 PM »

Some people here have alluded to the difference between Tissue Engineering and Regenerative Medicine.

While it's true that Tissue Engineering deals primarily with the manufacture and transplanting of new body parts, and Regenerative Medicine with coaxing the body to heal itself beyond the norm...

both borrow every heavily from each other, require each other, and share the exact same materials science.
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Re: Tissue Engineering
« Reply #87 on: March 23, 2016, 03:38:57 AM »

Billionaire, if what you say is true and we already have the technology available. How long do you think it'll be until we see the treatment made available to the public for peyronies? By the way, I totally agree with you about the shaming of male sexuality. But even women suffer from it in many instances too. Consider that no one even knew about Erectile Dysfunction until the drugs like viagra came out in the 90's.
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Re: Tissue Engineering
« Reply #88 on: March 31, 2016, 03:13:51 AM »

When I mail Wake Forest Urology they don't reply to me? Anybody got an update on how long this will take? I don't have much motivation left so it would.be nice to know what I'm waiting for and for how long. Theraphy doesnt help me, it just want to be able to get laid again dammit.
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Billionaire

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Re: Tissue Engineering
« Reply #89 on: April 04, 2016, 09:25:44 PM »

Gentleman. The regenerative medicine technologies have already been manifested.

The non-profits and patient advocacy groups are fighting in D.C. to clear the way for every imaginable Stem Cell / Regenerative Medicine Application worldwide.... except for Peyronie's Disease.

Patients for Stem Cells | It is our right to access our own stem cells for potential life saving therapies

- FasterCures

The regulatory and standard bearing agencies are familiar with and expecting companies to emerge.

Foundation for the Accreditation of Cellular Therapy

The investment firms focused on Stem cells have also arisen, and will even work with crowdfunding in addition to angels, seed, etc. (Run by industry eminences I might add)

http://www.poliwogg.com/

And that's just in in the US. There's movement in the UK, Australia, and don't get me started on China where anything goes.

Only two things are missing:

1. For the leadership of this organization to build a relationship with patient groups and D.C. lobbying entities like FasterCures.
And for us as as the Peyronies Disease Society (not individually) to "come out of the closet" and tell the public, market and government we exist in vast numbers,
as have done women for analogous vaginal conditions like MRKH with huge success.

2. For a team of firebrands to start a company in stem cell applications specialized for Peyronies Disease.

Also, what's being done at Wake by Dr. Atala is incredible, and we will surely transfer over knowledge from it, but tissue engineering of entire organs is overkill for the comparatively simple Peyronies Disease.
Dr. Badylak's I'll be analyzing in depth.

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popopo

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Re: Tissue Engineering
« Reply #90 on: April 06, 2016, 03:08:01 PM »

Are you surebBillionaire? I mean PRP is also called "stem cell treatment" by some but the effexlct isnt perfect. Also,what can we do about this? Inallready liked the fb page you asked us to like, but what next?
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Billionaire

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Re: Tissue Engineering
« Reply #91 on: April 07, 2016, 02:22:50 PM »

Are you surebBillionaire? I mean PRP is also called "stem cell treatment" by some but the effexlct isnt perfect. Also,what can we do about this? Inallready liked the fb page you asked us to like, but what next?

The infamous P-Shot.The limitation is that all independent, anecdotal procedures have retrofitted existing technologies to this condition to "see what happens", rather than created a new procedure to suit Peyronies Disease.

The next step is for us to fund the work of a Doctor-Institutional Researcher. There's a perfect candidate in mind but I'm reluctant to say his name because I don't want us all emailing him at the same time.

Popopo if what I'm saying makes sense, help me reach the administrators of this group. We would need them in the near future to help us send a call to action to every member of PDS to raise funds.

It would be done through a legitimate non-profit like Experiment.com and they'd head directly to a University Research Center.
All details and involved parties would be transparently displayed.

The Study would be Mesenchymal Stem Cells for Peyronie's Disease.

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james1947

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Re: Tissue Engineering
« Reply #92 on: April 08, 2016, 12:32:28 AM »

Billionaire

You don't need no one help to reach the active Administrator of this forum.
His forum name is LWillisjr and you may write him a PM

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

drew67

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Re: Tissue Engineering
« Reply #93 on: April 17, 2016, 07:34:34 PM »

In case this hasn't been posted: 

Stem Cell Technique Could Regenerate Any Human Tissue Damaged By Aging or Disease

trials start late 2017

Stem Cell Technique Could Regenerate Any Human Tissue Damaged By Aging or Disease

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james1947

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Re: Tissue Engineering
« Reply #94 on: April 17, 2016, 09:23:24 PM »

Thank you for the information Drew
I don't know who is managing futurism.com, hope they are serious people as not just sales advertisers.
Who will make the human trials? How can enroll? No information in the article in the subject.

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

Billionaire

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Re: Tissue Engineering
« Reply #95 on: May 02, 2016, 12:45:51 PM »

If you go to the original source listen on the bottom of the article, you'll see it's UNSW.


Quote deleted by moderator
Please read the forum rules!!!
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AphexTwin

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Re: Tissue Engineering
« Reply #96 on: October 13, 2016, 12:05:49 AM »

Where do i sign up for this? This is my last hope.
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AphexTwin

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Re: Tissue Engineering
« Reply #97 on: October 13, 2016, 12:19:08 AM »

If anyone could give info on how to get in on the trials, i would greatly appreciate it.
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nastyone

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Re: Tissue Engineering
« Reply #98 on: November 03, 2016, 08:31:58 PM »

This conversation caught my eye and I'm in the process of contacting Dan Wheelahan, seems he may run medicine there. I'll keep this updated with anything I hear regarding iMS(induced multipotent stem cells) clinical trials and research. I'm so sick and tired of all the suffering and pain I see on these boards. It's exhausting. We as a group need to come together and actively recruit more members that are willing to push for some change. It's so easy to give up simply from lack of treatment options. If nothing else, pushing toward treatments and an eventual cure will provide hope to those that need it most. I have no doubt there will be a permanent fix for peyronies, all we can do is try and hasten it.
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nastyone

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Re: Tissue Engineering
« Reply #99 on: November 03, 2016, 10:50:53 PM »

Well I emailed him as his title was under medicine..But I got an automated response that he is the media director, and on leave until november 9th.  I did request that he forward the message to whoever is in charge of stem cell research. I think I asked alot of good questions, so unless I find a better person to contact, I'll be playing the waiting game.
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