Colchicine

[Hontas]

After taking literally every other drug on the market including potaba, i have seen good results from only colchicine which is a highly toxic drug so thats that. I can objectively say that colchicine decreases my pain and curvature, which makes me think if i have some kind of arthiritis or gout triggering it. Maybe i should focus more on finding treatments for arthiritis and that could help too. Anyways, it seems to me like i have to constantly use Colchicine from now on . Either way, at least i found something helpful and i am really curious about any treatments you guys would recommend to me as its probably established now that what is happening to me is caused by arthiritis. I want to maybe tie this to other symptoms and stuff i have found out on the course of this disease, i am open to advices.  

[pey ron]

I tried one pill of colchicine once and it gave me pulsatile tinnitus.

More than anything else, I am afraid it might damage the DNA that one day I may pass down to children.

It appears to induce aneuploids and polyploids in plants and their offsprings. This scares the sh*t out of me.

I have a bottle of colchicine, and I would love to use it if I could get some authoritative reassurance on this.

[Bubba dawg]

Did a doctor prescribe this for you? I would go every 6 months for checkups while on this medication. Make sure the doctor is aware you are taking it

[Pfract]

I would stay away from it. Complete poison, with very few success if at all, and a lot of undesirable side effects or complications...  

[Old Man]

Note to all:

Colchicine is a drug that normally is RXd for gout. It works great for that malady, but the side effects in some folks makes it a drug to avoid. The problem is that one never knows what side effects will occur for them. The only way to really know for sure about side effects is to take a few doses to experiment, etc. This could be a risk, as there seems to be no known help for Peyronies Disease, etc. Just my 2 cents from experience in my case of Peyronies Disease.

FYI, I took bottles of it when I was 24 years old way back in the 1950s. It helped my gout, but did numbers of damage to my gastric system. So, I don't recommend using it any form for Peyronies Disease.

Old Man

[Hontas]

I have used colchicine it in extreme amounts(2 mg per day for months) before and didn't have a side effect other than elevated Creatine Kinase and a bit of myopathy. I have felt sometimes that its toxic effects built up on me and had some arrythmias, but considering how helpful it is i will consult a doctor for contionus use and take it on really low doses.

I don't get this forum promoting pentox and shaming colchicine, it is the other way around for me, if anything pentox actually helps those scar inducing white cells to reach the injury site causing more inflammation, while i think colchicine prevents them from causing inflammation.

I HEAVILY RECOMMEND that you try it at least for 2 weeks in low doses, but I DONT RECOMMEND using it for long time

So i actually used it before, its just that i didn't realise the first time that it stopped the progression
https://www.sciencedirect.com/science/article/pii/B9781437728644100156?via%3Dihub

[Bubba dawg]

You said you were open to advice. Obviously not lol

[Hontas]

Bubba Dawg

Did i say anything against the doctor check ups? I don't think so.  

[Christopher1]

Colchicine is an old medication that prevents white cells from migrating. It inhibits the microtubules, I believe. (Look this up - I am just going on my memory of it.)

As far as gout, other medicines are preferred because colchicine can cause unpleasant GI effects. If it works for you, it works because the white cells are not coming into the inflamed tissues to do their remodeling (i.e. tissue fibrosis).

[pey ron]

@old man: did you conceive children *after* using the colchicine? are they and their offsprings healthy?

thank you!

[Hontas]

pey ron

https://www.researchgate.net/publication/13722255_The_effect_of_colchicine_treatment_on_sperm_production_and_function_A_review

Take a look at this article, in healthy subjects they needed 3000 times more dose than the normal oral dose of 1-2mg to reach a sperm malfunction in healthy subjects. Other than that nothing was found to hurt


I would be more likely happy about genetic changes it brings, such as lowering inflammation. I am reading the article i linked right now,  and it is written in the article that it can alter gene expressions at higher doses, this is confirmed by me as when i took it 2.5 mg a day it really felt like my curvature was decreased. I might find another solution that does the same process without the same toxic effects. Looks like pretty much a great oral med for some peyronies sufferers.

I think it works by binding to tubulin which is crucial in transporting and creating extracellular matrix which is the plaque we know, so its actually toxic for muscles but at the same time helps inhibition of collagen. Local administration of the drug in the area could do wonders without the systemic effects.

[Bubba dawg]

You do need Collagen in the rest of your body

[Old Man]

pey ron:

Yes, we do/did have children after taking so many of the pills. We have three adult children (the youngest now 52 YO). And, we also have 8 grandchildren. Two are married and one has two great grand children.

None seem to have any ill effects of the med.,

Regards, Old Man

[Hontas]

Hello guys i just wanted to warn you just in case any one of you are using colchicine. Never take verapamil or inject verapamil while taking colchicine as it not only increases blood serum levels of colchicine to lethal levels, it also causes it to pass Blood brain barrier causing neurotoxicity. Always avoid colchicine with any type of P-gp inhibitors. In theory, colchicine's poisonous effects can actually be the mechanism that can stop the progression of the disease. Basically breaking down microtubules in your body which causes apostosis in cells. I am working out while taking it and didnt see the ill effects of it on my muscle growth tbh. I think more studies must be done about it since it might help (mild bend-flare up-repeat) type of cases that cover the minority of this forum. If you are one of those guys definitely try this medicine and let me know if it works and i can further advance on my research

Side note:

I did a full on research about the usual prophylactic levels of colchicine over the internet and i can safely say that in non-lethal doses colchicine cannot penetrate Blood brain barrier effectively by itself even if you use it long term. So even though neuropathy can occur in other places in your body, i am %95 sure that it wont damage your brain in the long run. My observations show me that 2 times a day 0.6 mg is the most effective and max safe dosage you can achieve with a totally healthy renal and hepatic functions, and at that level i dont feel the side effects.

[Hontas]

Ok definitely do try getting colchcine after a few days of injury, it literally reverses the fibrosis that has occured(if its new) and basically fight against the swarm of white cells and inflammation. For example i took 2 pills today and my serum levels were probably fairly high(around 3-4 ng/ml) and i finally saw its effect much better. Only time that i dont see it helping me is when i take a low dose. You can also use it similar to a gout attack and take high amounts of it after a few days of new acute phase and scarring. The scarring occured for me while taking colchcine but when i increased the dosage it reversed fibrosis. I read that there is a minimal dose for actual chemotaxis. I could even feel the new scar forming and just getting deleted from the universe in like less than 2 days. I have never had a complete instant resolution and this wasnt instant, it was actually quite painful and discoloration occured so i am really sure that it is with the help of the medicine

[hope794]

Hontas, sorry, i didnt understand properly. Are you saying that colchicine effectively reversed your fibrosis?

[Hontas]

It reversed the recent one(that happened a few days ago) basically after it heals with a scar tissue, it breaks it down and heals it much better next time is what my guess is. It didnt reverse the 3 month old one though.

[hope794]

Thank you for your reply

[Hontas]

Taking it acutely for a short time seems to work fine, maybe 3-4 days in a row

[Hontas]

Does anyone have an idea how to live like a normal person while taking 1.5 mg a day of this? It honestly completely stops my peyronies which i suspected was an autoinflammatory problem and its like the perfect drug for me, the catch is low doses dont help crap. High doses, i feel brittle, i lose muscle mass and i always have nausea and diarrhea. Do you guys take antiemetics or any other type of reliever while taking this drug? Is there anyone here with severe FMF that i can take advices from? It gives me tinnitus as well, a very bad one. Either way my only choice for cure is this drug so i am stuck with it.