Thymic stromal lymphopoietin

[slowandsteady]

No, I'm in engineering actually; it happens that I'm interested in health and supplements.

I used 23andme for testing, initially just because it was a way to see which polymorphism I had for folate metabolism (lots of people can't metabolize that nasty form of folate called folic acid, present in just about every multivitamin under the sun), and a sale was going on. I later upgraded to full access because I find the whole thing so interesting.

I haven't come across any supplement that affects thymic stromal lymphopoietin unfortunately (not to mention I'm uncertain whether it's active in the TA).

[boomerang]

Sounds good stuff, are you a medical person?
How did you get tested?
What is the treatment?

My next line of research will be genetic and which Polymorphisms are associated with Peyronies, Ledderhose, Dupuytrens, Hypodontia etc and is there a common link.

I would hope that if there is a set of Polymorphisms associated then gene therapy could be an answer.

Getting my family tested could be expensive at the moment unless you know of a low cost option.

I find it strange that only specific parts of the body are affected by associated conditions.

In the case of  Dupytrens only one finger on each hand, normally and in the case of my feet only two matching toes too.  How does  the condition know which fingers or toes to affect? Unless genetic.

Best regards

[slowandsteady]

I thought this might be worth a mention.

From the wiki article, "Thymic stromal lymphopoietin is a protein that in humans is encoded by the TSLP gene. ... It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. ... TSLP is produced mainly by non-hematopoietic cells as fibroblasts, epithelial cells and different types of stromal  or stromal-like cells.''

People having the G version of rs3806932 are associated with having lower levels of TSLP. My genotype for this SNP is AA, no G's at all.

From the Spittoon,

The TSLP protein is known to regulate inflammatory responses.  It is a key initiator of allergic inflammatory diseases and has been shown to be overproduced in atopic dermatitis lesions and asthma-affected lungs.  People with EoE often also suffer from these other allergic conditions.

So I'm potentially more likely to have fibroblasts that produce T cell-attracting chemokines which cause an inflammatory response.

s&s