PPAR agonists may help a ton!

[pey ron]

TLDR; PPAR agonists suppress the production of collagen induced by TGF-Beta. PPAR antagonists suppress the production of elastin [which to me means that PPAR agonists most likely stimulate the production of elastin]

In particular, look at this chart from the second paper below:



Involvement of PPAR nuclear receptors in tissue injury and wound repair

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1386118/


Activation of PPARs α, β/δ, and γ Impairs TGF-β1-Induced Collagens' Production and Modulates the TIMP-1/MMPs Balance in Three-Dimensional Cultured Chondrocytes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957135/


PPARγ Level Contributes to Structural Integrity and Component Production of Elastic Fibers in the Aorta

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865434/


The Functions of PPARs in Aging and Longevity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2254525/


Molecular mechanism of PPAR in the regulation of age-related inflammation

https://docdro.id/anKIRFk


Senescence Alters PPARG (Peroxisome Proliferator– Activated Receptor Gamma)-Dependent Fatty Acid Handling in Human Adipose Tissue Microvascular Endothelial Cells and Favors Inflammation

https://docdro.id/kcnlPLx