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Author Topic: 2017 - Trihydroxyphenolic compounds target fibroblastic TGF-β1 signaling  (Read 337 times)

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Cacogen

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Ellagic acid and corilagin selectively inhibit TGF-β1 in fibroblasts by targeting LOXL2:

https://www.jci.org/articles/view/94624

This is in the context of lung fibrosis, but might well be applicable to us -- if perhaps only those of us in the early stage.

"These studies reveal, for the first time to our knowledge, a pathway of inhibition of the TGF-β1–induced collagen program selective to the cells that are most accountable for pathological collagen deposition, tissue fibroblasts and fibroblast-like tumor cells. The surprising finding that such selectivity depends on active LOXL2/3 and appears to operate in a cell-autonomous manner largely abrogates inhibition by trihydroxyphenolic-containing compounds of TGF-β1 signaling in epithelial or immune cells that don’t express LOXL2/3. This selectivity likely avoids the toxicities of long term general TGF-β1 inhibition in chronic disease processes such as fibrosis and cancer progression. ... Although selective, the combined inhibition of LOXL2 and TGF-β1 signaling in fibroblast-like cells results in potent in vivo antifibrotic activity that has untapped but promising potential as a therapeutic approach for chronic diseases [...] dominated by progressive collagen accumulation."
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james1947

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Nice find Cacogen :)
Hopefully they will go forward and get to us also.

James
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Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
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Cacogen

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I include this here because corilagin is just a polyphenol -- an ellagitannin, more specifically -- which can be found in a number of plants. Extracts of Phyllanthus niruri contain corilagin (along with other polyphenols, I'm sure), and are available for purchase. These extracts appear to be non-toxic in rats at doses of 5,000mg/kg bw:

https://www.ncbi.nlm.nih.gov/pubmed/22319255

Pomegranate leaves also contain corilagin.

Active stage sufferers who are inclined towards self-experimentation might want to give it a try. Corilagin also appears to be a fairly potent inhibitor of a number of different cancel cells, in vivo.

Hmm, apologies if this post is miscategorized. Possibly it should be in the Oral Treatments section. 

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james1947

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Cacogen

Your topic is on the correct board

James
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