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Author Topic: PDE5 inhibitor preference  (Read 275 times)

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jj21

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PDE5 inhibitor preference
« on: December 06, 2018, 04:00:21 AM »

What do you guys prefer - cialis, viagra or levitra?

I've tried cialis which had good effects however, I suspect a tolerance is building..

Once tried viagra at 100mg had a rock hard erection but didn't last the whole night, also had to watch what I ate on it.

Anyone have other experiences? Anyone tried Levitra ?

Cheers,
JJ
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Age:30 - Symptoms for 6-7 months no improvement or worsening.... Prominent Left + Upwards curve when half erect.. Fully erect 5-10 degree curve only (relatively normal).. No Plaque found.. Mild Erectile Dysfunction...Possible suspensory ligament damage...

james1947

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Re: PDE5 inhibitor preference
« Reply #1 on: December 06, 2018, 07:08:34 AM »

Tried all three.
The only one that helped me was Viagra. By the way, it is not supposed to last all night.
Act best one hour after taking. Food intake should be limited.

James
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Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe Erectile Dysfunction.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
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skunkworks

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Re: PDE5 inhibitor preference
« Reply #2 on: December 06, 2018, 07:27:04 AM »

Levitra is the strongest inhibitor of pde5, followed by viagra then cialis in third. Levitra works noticeably better for me than CIalis and slightly better than Viagra.

Cialis also inhibits pde11, variants of which are all over the body and not completely understood. Can cause neck pain and possible decrease in sperm quality.

Viagra and Levitra inhibit pde1 and pde6, not too sure what they do either but I know pde6 affects the eyes.

Hawk

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Re: PDE5 inhibitor preference
« Reply #3 on: December 06, 2018, 08:13:34 AM »

I could tell no difference in the three as far as an erection was concerned.  I preferred Levitra because it's absorption is not hindered by fats that are eaten hours before.

I could not use Cialis because every time, the next day it felt like a mule kicked me in the back.
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skunkworks

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Re: PDE5 inhibitor preference
« Reply #4 on: December 06, 2018, 08:50:27 AM »

Yeah variants of pde11 are found in skeletal muscle.

philtered

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Re: PDE5 inhibitor preference
« Reply #5 on: December 06, 2018, 04:17:22 PM »

 I have no problem getting an erection , but have problems keeping it. Levitra works best for this IMO and less side effects. Cialis gives me back ache also.
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TonySa

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Re: PDE5 inhibitor preference
« Reply #6 on: December 06, 2018, 10:39:42 PM »

It’s different for everyone, you really just gave to try each.  Note Cialis has a longer half life and thus lasts longer (24 hrs) in your system.  One really doesn’t quickly develop tolerance on any of them...but Erectile Dysfunction can worsen w time rendering them less effective.
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Hawk

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Re: PDE5 inhibitor preference
« Reply #7 on: December 06, 2018, 10:52:19 PM »

Correct, I know of no tolerance build-up to PDE5 inhibitors.
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skunkworks

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Re: PDE5 inhibitor preference
« Reply #8 on: December 07, 2018, 12:33:43 AM »

No tolerance over 6 months with cialis - https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1743-6109.2006.00248.x

Thing is that it is a hard one to measure, because chronic use of pde5s usually leads to you needing pde5s less. Actually I had a post about this earlier, will just quote it here:

-------------------------------------------------------------------------

Now about daily use, with regards to pharmacokinetics it might be true that a tolerance could be built up. But in effect, daily use of pde5s actually decrease the need for pde5s. This is most likely due to frequent erections being healthy for the smooth muscle and other parts of the penis, and of course blood flow.

I do not have time to find all the studies, but here is a writeup of an old one. This one is interesting because it compares nightly (every night) use vs as needed use vs no viagra at all. And in particular erectile function after all treatment in all groups had been stopped - https://www.webmd.com/erectile-dysfunction/news/20040513/nightly-viagra-may-restore-normal-erections#1

He and his co-investigators studied 76 men who had erectile dysfunction for at least six months. Group 1 took 50 mg of Viagra nightly at bedtime. Group 2 took 50-100 mg of Viagra when they wanted, presumably before sexual intercourse. The investigators also followed a third group of men with erectile dysfunction who received no treatment. The men were an average of 47 years old.

After 12 months of nightly Viagra followed by one month of no erectile dysfunction treatment, nearly 60% of men in group 1 had a return of normal erections. Less than 10% of men that took Viagra as needed had a similar return of normal erections.

At the end of a six-month period without any erectile dysfunction treatment, all but one of the men in group 1 still had normal erections. Normal erections were determined by an erectile function questionnaire completed by the men.

Researchers also measured blood flow to the penis. After one month of no erectile dysfunction treatment, group 1 had a significant improvement in blood flow. However, group 2 had no significant change and blood flow, and group 3 worsened.


betterbend

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Re: PDE5 inhibitor preference
« Reply #9 on: December 07, 2018, 02:21:32 PM »

I have no problem getting an erection , but have problems keeping it. Levitra works best for this IMO and less side effects. Cialis gives me back ache also.

Try doing some Kegels exercise for men.  It can help you keep the blood in you penis once erect...
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jj21

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Re: PDE5 inhibitor preference
« Reply #10 on: December 08, 2018, 03:52:10 AM »

Skunk, that's an interesting study... So daily nighttime use of Viagra could restore sexual function?
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Age:30 - Symptoms for 6-7 months no improvement or worsening.... Prominent Left + Upwards curve when half erect.. Fully erect 5-10 degree curve only (relatively normal).. No Plaque found.. Mild Erectile Dysfunction...Possible suspensory ligament damage...

skunkworks

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Re: PDE5 inhibitor preference
« Reply #11 on: December 08, 2018, 06:00:10 AM »

Well in that study it did and it's not surprising. Erections are good for erections. I've been saying that for a long time now, and still get people popping up here saying they are avoiding erections as much as possible and even some that say their urologist told them to avoid them as much as possible.

There is only one time that advice is applicable with regards to Peyronie's and that is immediately post surgery. 

TonySa

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Re: PDE5 inhibitor preference
« Reply #12 on: December 08, 2018, 04:40:00 PM »

Other studies support that NTE due to PDE5 meds also remodel plaque to healthy tissue.  Use it or lose it!!!!
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Hawk

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Re: PDE5 inhibitor preference
« Reply #13 on: December 08, 2018, 06:43:13 PM »

I think NTE 's make for a healthier penis no matter how you get them including Trazadone or even L-Arginine if it works.
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skunkworks

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Re: PDE5 inhibitor preference
« Reply #14 on: December 09, 2018, 09:57:57 AM »

Erections on the whole, even stimulated ones will be beneficial as long as the stimulation itself is not damaging. There is probably something more beneficial to nocturnal erections, but any erection gained by means which are not physically damaging is going to be a good one for future function.
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