Daily Use of Sildenafil

Previous topic - Next topic

0 Members and 1 Guest are viewing this topic.

ripcurl09

This relates to both Peyronies and Erectile Dysfunction, so I thought I'd put it there.

I see on this board and many other Penis and ED forums that people take Sildenafil (Viagra) and/or Cialis on a daily basis. I have a couple of questions about this.

1. How can this help with correcting PY disease?
2. How can this help with ED? Most of the time that you take a medicine on a regular basis, you body adapts by discontinuing to perform that action on its own. Therefore, taking an ED medicine every day would seem to cause even more ED.

Thanks!
45 Year Old Whit Male, 2016 Penile injury during sex, significant curve up, loss of approx 2" length and 27% girth, Trying VED & Traction for restoration

skunkworks

Pde5 inhibitors have an antifibrotic effect, that has been shown in a few studies on cystic fibrosis, liver fibrosis and there have been a few involving peyronie's specifically. They are mentioned here - https://www.nature.com/articles/3901362.pdf?origin=ppub

https://www.renalandurologynews.com/erectile-dysfunction/daily-tadalafil-may-be-effective-for-peyronies-disease/article/708771/ - Daily Tadalafil May Be Effective for Peyronie's Disease

There is also this study on the remodelling of penile septal scarring with daily cialis - https://www.ncbi.nlm.nih.gov/pubmed/21324095

Now about daily use, with regards to pharmacokinetics it might be true that a tolerance could be built up. But in effect, daily use of pde5s actually decrease the need for pde5s. This is most likely due to frequent erections being healthy for the smooth muscle and other parts of the penis, and of course blood flow.

I do not have time to find all the studies, but here is a writeup of an old one. This one is interesting because it compares nightly (every night) use vs as needed use vs no viagra at all. And in particular erectile function after all treatment in all groups had been stopped - https://www.webmd.com/erectile-dysfunction/news/20040513/nightly-viagra-may-restore-normal-erections#1

He and his co-investigators studied 76 men who had erectile dysfunction for at least six months. Group 1 took 50 mg of Viagra nightly at bedtime. Group 2 took 50-100 mg of Viagra when they wanted, presumably before sexual intercourse. The investigators also followed a third group of men with erectile dysfunction who received no treatment. The men were an average of 47 years old.

After 12 months of nightly Viagra followed by one month of no erectile dysfunction treatment, nearly 60% of men in group 1 had a return of normal erections. Less than 10% of men that took Viagra as needed had a similar return of normal erections.

At the end of a six-month period without any erectile dysfunction treatment, all but one of the men in group 1 still had normal erections. Normal erections were determined by an erectile function questionnaire completed by the men.

Researchers also measured blood flow to the penis. After one month of no erectile dysfunction treatment, group 1 had a significant improvement in blood flow. However, group 2 had no significant change and blood flow, and group 3 worsened.


This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

ripcurl09

[Full quote removed]

Very, very helpful and informational response. Thank  you! I am going to read your article links and related articles in details, but you have definitely shed some light on the potential benefits of daily Viagra use. Since I get it from my local pharmacy for so cheap, it will be easy for me to do as well.
Thanks again!
45 Year Old Whit Male, 2016 Penile injury during sex, significant curve up, loss of approx 2" length and 27% girth, Trying VED & Traction for restoration