Tamoxifen

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Hontas

Has anyone used it here before? I would like to get your inputs about this med it looks like it has really serious almost lethal side effects even though i am not one to complain about the side effects, this looks bad. But if it helps it helps and i wanna know if it did in your case?

diehardpatriot

Isn't that an estrogen medication? Why would you take that  
Penis injury in late 2017. A lump formed at injury site that caused no deformity, just pain and a palpable lump. Pain is improving through proper rest and use, diet, and mindfulness. I am always learning and looking to share things that have helped.

Hontas

it is used for treating peyronies. they have some literature on it. Dont know how the process works. Also considering i am suffering from high estrogen and prolactin it might be helpful. Also, if there is a specifically prolactin inhibitor i would maybe try that one.

TonySa

Tamoxifen - early peyronies studies but not much came of it.  I'd go w the more proven strategies.
PxD 2 yrs 9/16.  Failed all treatment. 9/11/18: excision, grafting & implant Dr Karpman MtnView Ca, AMS CX 18cm + 3-1cm RTEs.
Pump failed.  2/11/20 Dr Karpman installed Titan 22cm +1cm RTE.

Cacogen

There may be a synergistic effect when combining Vardenafil and Tamoxifen.

Antifibrotic Synergy Between Phosphodiesterase Type 5 Inhibitors and Selective Oestrogen Receptor Modulators in Peyronie's Disease Models

"The new assay was able to detect transforming growth factor-β1–induced myofibroblast transformation. Using this assay, phosphodiesterase type 5 inhibitors (PDE5i) and selective oestrogen receptor modulators (SERMs) were identified to significantly inhibit myofibroblast transformation. A PDE5i (vardenafil) and an SERM (tamoxifen) inhibited myofibroblast transformation, collagen gel contraction, and extracellular matrix production in a synergistic fashion. In a rat model of Peyronies Disease, the antifibrotic effect of the combination of vardenafil and tamoxifen was greater than that of each drug alone."

https://www.europeanurology.com/article/S0302-2838(18)30755-3/fulltext
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jj21

I did use tamoxifen for bodybuilding purposes. I used it for about 6 weeks, 40mg the first four weeks and 20mg the last 2 weeks.

It didn't do much at all in terms of improving curvature or improving symptoms. However, there was a study which found 3 months of use at 40mg per day reduced curvature (although less than ACL).

Just be aware that some people lose their libido on tamoxifen and have ED while on the drugs (for others it can be the opposite case).

Cheers,
JJ
34 Years Old...Peyronies for 4 years. 20 Degree left and upwards curvature, major dents and narrowing, ED.

Implant + Tunica Expansion Procedure, 7th Feb 2023, Titan 22cm +1cm RTE, Partial revision 27th June 23 (fix pump, remove 10ml reservoir).

picgg

I used it for four weeks, and I has to stop it due to side effects
36 Yrs Old, Peyronies since 03/2018
Hourglassung Subcutaionus atrophy & Mild ED after Steroid injection
Flaccid pain, Curvature to the left
Tried ALC, L-Arginine, COQ10, Pentox, Tamoxifen, Cialis, fexofenadine, Vit E - Nothing is working.

Christopher1

Tamoxifen is more used for ER-positive breast cancer. Lol.
Snake Diet + 5-day fasts + pentox + NeoV's stretching routine + Mito Red Light. Curvature 99% gone.

I also used Todd Capistrant's "Fascial Distortion Model" to help my curvature. Start slowly.

skunkworks

https://www.ncbi.nlm.nih.gov/pubmed/1486392 - The treatment of Peyronie's disease with tamoxifen.

Tamoxifen is used for many conditions. It's even used by bodybuilders in their post cycle therapy.  
This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

Cacogen

It really sounds like -- if one were going to try it at all -- you would want to give it a go in combination with a PDE5 inhibitor.
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Christopher1

Interesting study.

Are there others you found?
Snake Diet + 5-day fasts + pentox + NeoV's stretching routine + Mito Red Light. Curvature 99% gone.

I also used Todd Capistrant's "Fascial Distortion Model" to help my curvature. Start slowly.

skunkworks

Good find @cacogen, thanks for posting it
This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

pey ron

I have been taking 20mg tamoxifen twice a day, along with 5-7.5mg of cialis (tadarise), 1200mg of spirulina and 400mg of biotin (yes milligrams, it's not a typo). Hopefully they have a synergistic effect.
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Hontas

Pey ron
Dude just make sure you are not prone to heart attacks as i feel like that mix of tamoxifen and cialis looks dangerous.

popopo

I wouldn't mess with tamoxifen. I developed floaters from clomid which is a very similar drug. If I would take anything (for high estrogen, not peyronies) it would be Aromasin. Works a little different, but prevents your testosterone from converting to estrogen. Anyway, if you have hormone problems it might be best for you to get to a good doctor to get you on real TRT. Other than that all you can try to do to battle high estrogen is stay in shape and get enough zinc, magnesium and vitamin D. If you're overweight it can cause your testosterone to convert more to estrogen, but I don't know you so it might also be genetic, but even then there are some things to battle higj estrogen. If it's any good for peyronies I don't know. I've been on testosterone for a while myself and don't notice much difference than being natural other than muscle AND fat gain which happened way faster on testosterone. Naturally my levels are low-average, but appearantly my peyronies isn't caused by that nor does it get better on a high T level, so I wouldn't worry about it too much.
Age: 25
Date of onset: 17
Symptoms: sharp pains, numbness, change in shape/size, hourglassing and discolaration from jelqing/VED usage as a teen. Diagnosed with a venous leak and possible scarring.
Treatments tried: cialis, pentox and VED didnt help