Theories and Speculations of YoungFella for young kids

[YoungFella]

in this thread I would like to share my crazy theories with you , mainly for the young generation..

Let's start with some few qoutes :
Do not penal pump or do jelqing these cause more Scar Tissue develop... The penis is not a muscle it's a balloon... You could not stretch and grow unless you have enough nitric oxide DHT and prostaglandin E1... Overproduction a prostaglandin E2, accompanied by a deficiency of nitric oxide and testosterone and DHT will cause penis shrinkage and Scar Tissue development... Finasteride actually thins the Tunica, and causes more scar tissue -- raypeat's forum member.

TGF-Beta is one gene that causes systemic fibrosis, including that of penile tissues. Increasing deposition of collagen (restricting cortisol and estrogen should then also help)
Transforming growth factor beta (TGF-β) as well as other fibrotic cytokines has been shown to induce fibrogenesis in the corpora cavernosa [4]. Elevated TGF-β expression and fibronectin has been noted in animal models of cavernous nerve (CN) injury-induced penile fibrosis [5,6].
Valproic Acid Prevents Penile Fibrosis and Erectile Dysfunction in Cavernous Nerve Injured Rats
(Valproic Acid is an anti-androgen and anti-progestin so I'm not advicing it, just posting it as a reference for TGF-Beta mechanisms)

It is also higher in conditions of liver damage leading to not only increased liver TGF-Beta levels but also increased systemic ones. Reversing such damage (PUFAs, Iron and Endotoxins reduction; Antioxidants, ATP optimization and systemic decalcification) will lead to lower TGF-Beta levels and direct inhibitors of TGF-Beta also help since it causes liver damage itself.

Such TGF-Beta inhibitors are : Taurine, Zinc, Ginger, Vitamin D and UV, Extra Virgin Olive Oil, Milk Thistle, Emodin, CO2 (protecting against hypoxia which increases TGF-Beta), Antioxidants (smoke oxidation increases it).

I learned about this on a propecia support forum during my post-propecia recovery and using such strategies helped me and I think others had positive testimoni

anthoer member see a connection between Estrogen and fibrosis , Estrogen is known to increase collegan

Ray Peat wrote:

Unopposed estrogen promotes inflammation and fibrosis, pregnenolone, progesterone, and testosterone protect against fibrosis. Hypothyroidism tends to push the ratio toward estrogen.

Estrogen steals oxygen from mitochondria, shifting patterns of growth and adaptation.
-raypeat


Estrogen, by creating an oxygen deficiency, stimulates first swelling, and then collagen synthesis
raypeat^^

2018 Update on Peyronie's Disease - What's Around the Bend
Dr Moheit Kherra -  2018 Update on Peyronie's Disease - What's Around the Bend
https://www.youtube.com/watch?v=l8BLsd3QF9o&t=394s
his new research is Based on testosterone and Vitamijn D3 , which is not suprised me, as a tool to Curve stablization.

my crazy treatments ideas :
1.Some sort of Androgen and Pentox , my only concern is that androgen increase RBC and Pentox makes RBC more flexable , maybe it is good.
2.High dose of K2 with Serrapeptase to break scar tissue.
3.heavy androgen steroid like Halotestin with HGH and traction. - with I truly believe is uneffective without dht.
4.Buteyko Breathing Technique to increase CO2 ,this method has a record for treating Astama and Chronic diseases .
5.Full panel testing of Hormones, including T4 Reverse t3 and t3.
6.Combining Heat and Cold thearpy, cold when there is a flare up and heat when there is some sign of reduced inflamation.
7.IGF-DES localized igf 1 with short half and traction.
8.tb-500 , maybe BPC-157 , what scares me about bpc-157 is working with collegen and tendons.
9.Dr levine already say that people with peyronies have missing enyzmes , Aromatse enyzme and contisol convertion is whta comes to mind , maybe even some digestive enyzmes related to proteins.

I dont think everybody that have peyronies have diabetes as my Endocrinologist said that for im not prediabetic.

My main point is that there is an increasing young people who get diagnosed with Peyronies and I am convinced that the basic cause is the same but the treatment is different.
the good news is Im willing to try my theories on myself,  after believing that Peyronies is Caused by some androgenic problem of young people.
there is a reason of the first idea of reseachers of Tamoxfine ,Hydrocrotisone, and Vitamin E - > all of them have conection to Estrogen.

more to come soon after my experiments.

[hope794]

I'll follow your experiments with much interest!
I think that a testosterone deficiency may have a strong role in Peyronie's disease.

[YoungFella]

New possible treatment to avoid further progession is the dopmaine and serotonin ratio.
I encourage everyone to check their prolactin levels in their blood , because prolactin is a dopmaine antagonist.
which means - less dopamine more serotonin now to the punch line:
Potassium aminobenzoate (Potaba; Glenwood, Englewood, NJ) has been prescribed extensively for Peyronie's disease.26 Its mechanism of action is not understood but may involve decreased fibrogenesis through altered serotonin levels
less serotonin less fibrosis , but potaba is not very effective , maybe something stronger like a real life dopmaine agonist like Cabergoline and B6 worth considering .
Another cause for serotonin syndrome is gut bactria, which can be cured by antibiotics and even bpc-157

[jj21]

YoungFella,

Any updates on the experiments? Interested in what you may stumble upon... Just be careful you dont exacerbate your condition.

I'm trying IGF1 LR3 for bodybuilding purposes at the moment - just a low dose.. I'm doubtful it will have much effect.

Cheers,
J

[BAtBAt]

@YoungFella, this is amazing. Thanks so much for this!

[BAtBAt]

Also admire your brain

[james1947]

YoungFella

I am not in the category of age you started this topic for, but I am wandering what you have done from your list and if have some results.

James