PENTOX - Side effects

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0x5555

Question on getting off pentox: do I need to wean myself from it?  What have other people's doctors told them?  My doctor is off for the holidays.  I cannot continue like this - I had half a banana and a bagel all day and I feel awful - absolutely no desire to eat anything and kind of sick.  No energy obviously.

corvette2010

i'm 99% sure you can just stop it. I had stop for a while bc it was giving me headaches and I quit without weaning. I did go back to just 2 pills a day and I feel great with that dosage.

rd

I was on it for a few months and then completely stopped taking it and didn't experience any issues.

mike67

I asked my Uro / surgeon if I should stop Pentox . L'Arginine and VED prior to my surgery Feb.2.
He replied stay on the VED , stop Pentox & L'Arginine. Nothing about a gradual stoppage.
Mike
Mikey

0x5555

Yup, I got in touch with a urologist from that clinic - he said stopping cold turkey is OK.  I may try this for the next few days.  I also got a TON of bloodwork done to rule out anything crazy like vitamin deficiencies or mono.  Tomorrow have the consult with the psychologist to talk about my depression.  I'm sure that will be interesting, never had to talk with anyone like that before.

I should mention, the doctor I spoke with prescribed trazodone to help me sleep but I notice one rare side effect is priapism, so I think I'll skip that.  

Woodman

I was having a hard time a while back with dealing with my Peyronies, other health problems going on at the sametime, also along with family and relationship problems etc. I found when I was on Pentox it intensified my depression and feelings where I got very very low where it took everything I had to get out of bed to go to work in the morning. Also I would be on a emotional roller coaster. From kinda ok to just wanting to breakdown. I got real quiet too after a while and didnt speak much too anyone. I figured out the Pentox was doing it to me as a side effect. It usually slowly took effect after a few weeks usage and slowly built till it got bad in a month to two month period.

I had to discontinue using Pentox and over a period of about 3 weeks it would slowly get better the longest time was about a month to resolve the side effect. If you do a search under my screen name woodman I wrote about it here on the forum in detail.

In short I found that if your in a rough low spot in life where you are already battling the mental aspects of Peyronies, plus a little depression along with everything else it can effect you this way. I even asked my uros PA and a month later he told me he had another patient that had the same experiance. I hope this might help a bit.  

0x5555

Haven't taken the pills for 2 days - feel QUITE different.  Appetite seems to have returned and I just generally feel better.

I don't know how much this is just in my head or not but it's certainly a change from how I've been feeling for the last month or so.

fubar

Voodoo,.good chance it is setteling in your head. Pentox,  ubiquinol, or cialis are not goining to cause adverse trauma to your head.The pump or stretcher can promote you to the next evolution .

Fubar

0x5555

Update:

Just wanted to let you guys know I am sooooo much different without taking the pentox.  It's hard to explain but my energy levels are back and my appetite is back.  I feel much more like my normal self.  The biggest change is my appetite - hard to explain but even just a week ago I basically had no desire to eat food.  All food was about as appetizing as a bowl of mud.  I could force myself to eat it but it would be about as easy as forcing yourself to eat dirt - best way I can describe it.

Pretty disappointing to be honest - I was really hoping the pentox would help in some ways.  

MikeSmith0

Quote from: 0x5555 on December 27, 2011, 05:10:35 PM

Pretty disappointing to be honest - I was really hoping the pentox would help in some ways.  

It is in a family of drugs that are stimulants.  Some people find this harder to tolerate than others. What happened to you is similar to what happened to me.  My sleep was screwed up, I was moody (from not sleeping), my appetite was fine (but most appetite suppressants are stimulants - so not surprised by this).  I also don't really like  how i feel from coffee / caffeine... they are distantly related, but apparently close enough to some people's brains.... other people dont notice a thing.   It also upset my stomach...like caffeine...so, I stopped too.

Don't be too disappointed, it's not a magic bullet.

0x5555

Yeah, I'm OK - life goes on.

neptune

Hello all, new to this forum- 29 y/o with Peyronies Disease as of 2.5 years ago. After some missed diagnoses I was finally given the proper info on my condition and was assigned Pentox. I was on for 9 months then took myself off, and a few months ago was put back on.

After meeting with my urologist four months after being put back on, he doubled the dose (now six 400 MG tablets a day, two at a time) and I've really noticed a huge change in the side effects, esp. if I forget to take with a meal or am out and about without the meds. Even still I have a lot of nausea, which I am prone to anyways as I also have some GI issues (my body has given me lots of challenges throughout the years!)

Does anyone else suffer through the side effects to a fairly uncomfortable degree? I want to try this double dose still as long as I can, as I was starting to make progress (ie, the scarring and calcification stopped growing) and am willing to put up with the side effects for the time being. One of my solutions to this has been medical marijuana- I live in a state where it is legal and I have proper documentation- though I am concerned about the restriction of blood vessels, which I assume may also be reversed by the amount of caffeine I intake every day. I asked my urologist who is one of the top experts on the subject and he said there was no official data on the subject at all.

Thanks everyone...

GS

I'm pretty sure most of our forum members are only taking 2 or 3 Pentox per day.  My doctor prescribed 2 a day for me and I have never had any problems.

6 sounds like a lot to me, but I'm sure you will get more feedback from some of the more knowledgeable members.  

GS

rd

I tried 6 a day after the original post of Dr Lue prescribing this to some patients. I didn't have any real side effect except for a headache every now and then. I don't usually get headaches they weren't often but seemed to be slightly more than what I'm use to getting which is pretty much none. But I think I tolerate pentox well and haven't had the problems some have had with even min doses

Skjaldborg

I had some minor GI side effects while on 1200mg pentox per day. Taking it with food and avoiding very acidic foods (Orange juice, red sauce, etc.) seemed to help. As far as self medicating with marijuana, I can imagine that there is no data on how it would affect Peyronie's disease. My best guess is that in moderate doses it would not. However, inhaling any combusted material, be it tobacco or wood smoke, is tough on the lungs.

Skjaldborg

james1947

I wish I had read this topic two weeks ago when I get cold/flue and reduce Pentox for one per day.
I continue with Pentox 2 daily 400mg and the cold/flue was over just now after two weeks and still cough very strong specially if I lay down.  
Usually it takes me less than one week to be over.
James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

PablitoNJ

Interesting thread. I've been on Pentox for about 90 days and have had this lingering sinus issue since Christmas time. Usually it will clear up in about a week. This time after a round of antibiotics, it's still acting up. I will have to see if going down to one pill a day will help clear it up. On another note, similar to Woodman, I had a bout of athlete's foot - very rare for me - that didn't clear up with OTC medicine. Had to get a prescription strength medication. It might be all coincidental, but reading similar experiences makes me wonder if there is more to this.  

rd

I have to say last year I exprienced the samething lingering cough got sick more than normal while on pentox. This year however I have not, even though people all around me are sick. The only thing different between last year and now is that I cleaned up my diet a lot. I'm not sure what you guys typically eat but I cut way down on processed foods and try to make the bulk of my meals raw fruits and veggies and enough meat home cooked for the protein I need. I haven't been sick once even with all my coworkers coughing, sneezing and calling in sick. Even the client sites I work at I haven't gotten sick from the coughing, sneezing, and sickly employees. Maybe its just by chance but I do feel better over all. The meats I eat I try to only get free range, that were fed a natural diet but I am not finding much in the way of  beef or chicken so I tend to lean towards sea food that was cought not farm raised. Just something to think about if you find yourself getting sick more often on pentox.

George999

Yup.  Healthy diet and sufficient vitamin D can help tremendously in warding off infections.  They can also help tremendously in overcoming Peyronie's.  I am convinced that the reason that some do well on things like Pentox and others don't has to do with such things as diet and exercise issues.  - George

ComeBacKid

Hey guys, this is my second true time on pentox, I did get sick more on pentox.  I have daily sinus leakage down the back of my throat which causes gagging, especially when I"m out in colder air, when the tempature is below 40 degrees.  I had this problem the last time I was on pentox as well, I believe the pentox causes sinus irritation.  Last time when I was on three pills per day, I had daily headaches and even more sinus leakage.  For some reason somehow the pentox seems to irritate the sinus cavity, it could be quite simple, or quite complex, I don't know, but its still worth the positive gains I've seen from the drug at this point.  

As for it being an immune suppressant does that mean it weakens the whole immune system, or stops the overactive immune system from attacking healthy cells?  If we are all getting sick more often and longer, it looks like it could mean pentox weakens the entire immune system.

Comebackid

restore

Interesting, I've had chronic shoulder pain for about six weeks now.  I'm going to have a checkup soon that includes a physical and blood drawn, will see.  I've been on pentox for 9 months probably 3 times a day 400mg.

goodluck

Come back Kid,

Try nasal irrigation with a Netti pot.  I swear by it when ever I get some kind of nasal irritation or the sensation of a cold coming on.  The trick is to get the temperature of the water close to body temperature and use a small amount of USP salt.  
I don't use tap water becasue it has all kinds of junk I don't want in my body.  I use bottled spring water which I heat on the stove.
Simple and effective.

GoodLuck

UnholyErexshuns

Smokin dope made my tallywacker hurt the most and shrink, if your lookin to use illegal substances to cope(not a good long run choice) try hydrocodone syrup or promethezine codeine will be pain free a juicy for a couple days

corvette2010

Quote from: UnholyErexshuns on February 18, 2012, 09:48:27 PM
Smokin dope made my tallywacker hurt the most and shrink, if your lookin to use illegal substances to cope(not a good long run choice) try hydrocodone syrup or promethezine codeine will be pain free a juicy for a couple days


Or not.

neptune

Thanks for the responses. It's been a bit better recently, but I've been more mindful of taking with food or milk/yogurt and perhaps my body is adjusting. It does seem like quite a lot, but I rather be safe and deal with the minor inconveniences now if it's going to be more effective. Using marijuana was not a way of coping, rather to relieve the nausea etc. from the Pentox. I've also noticed some blurry vision, which I've read can be a side effect- has anyone else experienced that?

Iseilinus

Hi Neptune,

That is a lot of Pentox.  Keep us posted please.

Luciano

That reminds me of a thread here in the forum of someone else who was a patient of Tom Lue.
Lue also doubled his dose of pentox.
I do not know how it turned out. But if you find the thread, it would be good contacting him.
Luc

james1947

Everyone would like to see his Peyronie's gone as soon as possible. I also appreciate Dr. Lue big knowledge in the subject.
From the other side, I read on the Internet that the Pentox maximum daily administered quantity should not exceed 20mg per 1Kg of body weight.
So if someone weight is 80Kg/176.4lbs the maximum daily intake should be 1600mg, it makes 4*400mg per day.
Maybe I am too conservative and worry?! I don't know.
James  
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

LauRenT

"OVERDOSAGE
Overdosage with Trental (pentoxifylline) has been reported in children and adults. Symptoms
appear to be dose related and usually occurred 4-5 hours after ingestion and lasted about 12
hours. Initial manifestations of acute overdose with pentoxifylline may be nausea, dizziness,
tachycardia, fever, gastrointestinal bleeding – coffee-ground vomiting and areflexia.
 The highest amount ingested was 80mg/kg with which flushing, hypotension, convulsions, somnolence, loss
of consciousness, fever, and agitation have been observed. All patients recovered.

No specific antidote is known. In addition to symptomatic treatment and gastric lavage, special
attention must be given to supporting respiration, maintaining systemic blood pressure, and
controlling convulsions with intravenous diazepam. Activated charcoal has been used to absorb
pentoxifylline in patients who have overdosed. "

Source: http://products.sanofi.ca/en/trental.pdf

Laurent

MattF

I don't know if this has been discussed before so please forgive this newbie if it has.

The only side effect that I have with Pentox is that it acts as a powerful diuretic. I see why some bodybuilders take Pentox before a contest to get that cut-look.

The first dose I took was right before bed and within 10 hours, I urinated one gallon!! Yes, I keep a measuring jug by the side of my bed for a previous bladder issue I had and I used it to test what was happening to me with the Pentox.

I urinated so much that I became dangerously dehydrated. I had sharp pains in my side that had not happened since I was 7 years old when I was hospitalized for dehydration. This time I just kept drinking till the pain stopped, and thank God it did.

But that leaves this problem. I can't be running to the bathroom every 15 minutes when on Pentox.

I'm just wondering if anyone else has had this side effect and if so, does it go away, or is this something that I'm stuck with until hopefully this 90 degree bend in my penis goes away?

Please share your thoughts. Thank you.

fubar

I really have not had that problem or any side effect from pentox.I am diabetic and when my sugar levels are out of controll i have an unquenchable thirst and run to the bathroom constantly.So maybe it could be something else?

Hope you can get to the bottom of it.I personally know how agrivating it is to get out of bed constantly to urinate.

Fubar

KAC

I haven't noticed any problems with it being a diuretic.  I drink too much coffee so I probably urinate more frequently than many, but I noticed no change with Pentox.

corvette2010

I haven't had any problems with it being a duiretic either. Only problem I had was at 3 pills a day it gave me a headache so I take 2 a day now.

dioporcolorisolvo

Quote from: MattF on March 04, 2012, 10:10:32 PM
I don't know if this has been discussed before so please forgive this newbie if it has.

The only side effect that I have with Pentox is that it acts as a powerful diuretic. I see why some bodybuilders take Pentox before a contest to get that cut-look.

The first dose I took was right before bed and within 10 hours, I urinated one gallon!! Yes, I keep a measuring jug by the side of my bed for a previous bladder issue I had and I used it to test what was happening to me with the Pentox.

I urinated so much that I became dangerously dehydrated. I had sharp pains in my side that had not happened since I was 7 years old when I was hospitalized for dehydration. This time I just kept drinking till the pain stopped, and thank God it did.

But that leaves this problem. I can't be running to the bathroom every 15 minutes when on Pentox.

I'm just wondering if anyone else has had this side effect and if so, does it go away, or is this something that I'm stuck with until hopefully this 90 degree bend in my penis goes away?

Please share your thoughts. Thank you.

I have had the same problem.

You have to start with small dose (200mg daily) and increase gradually.

MattF

Quote from: dioporcolorisolvo on March 05, 2012, 11:26:26 AM
Quote from: MattF on March 04, 2012, 10:10:32 PM
I don't know if this has been discussed before so please forgive this newbie if it has.

The only side effect that I have with Pentox is that it acts as a powerful diuretic. I see why some bodybuilders take Pentox before a contest to get that cut-look.

The first dose I took was right before bed and within 10 hours, I urinated one gallon!! Yes, I keep a measuring jug by the side of my bed for a previous bladder issue I had and I used it to test what was happening to me with the Pentox.

I urinated so much that I became dangerously dehydrated. I had sharp pains in my side that had not happened since I was 7 years old when I was hospitalized for dehydration. This time I just kept drinking till the pain stopped, and thank God it did.

But that leaves this problem. I can't be running to the bathroom every 15 minutes when on Pentox.

I'm just wondering if anyone else has had this side effect and if so, does it go away, or is this something that I'm stuck with until hopefully this 90 degree bend in my penis goes away?

Please share your thoughts. Thank you.

I have had the same problem.

You have to start with small dose (200mg daily) and increase gradually.



Thanks to everyone for their thoughts.

dioporcolorisolvo, did you cut the 400mg tablet in half and then further split the tablet into 1/3's and take a third every 8 hours? Or, did you split it into half and just take one of the halves for the whole day?

Please let me know what you did to get around this problem and how soon the issue resolved itself. Thank you.  :)



dioporcolorisolvo

Quote from: MattF on March 05, 2012, 12:55:34 PM
Quote from: dioporcolorisolvo on March 05, 2012, 11:26:26 AM
Quote from: MattF on March 04, 2012, 10:10:32 PM
I don't know if this has been discussed before so please forgive this newbie if it has.

The only side effect that I have with Pentox is that it acts as a powerful diuretic. I see why some bodybuilders take Pentox before a contest to get that cut-look.

The first dose I took was right before bed and within 10 hours, I urinated one gallon!! Yes, I keep a measuring jug by the side of my bed for a previous bladder issue I had and I used it to test what was happening to me with the Pentox.

I urinated so much that I became dangerously dehydrated. I had sharp pains in my side that had not happened since I was 7 years old when I was hospitalized for dehydration. This time I just kept drinking till the pain stopped, and thank God it did.

But that leaves this problem. I can't be running to the bathroom every 15 minutes when on Pentox.

I'm just wondering if anyone else has had this side effect and if so, does it go away, or is this something that I'm stuck with until hopefully this 90 degree bend in my penis goes away?

Please share your thoughts. Thank you.

I have had the same problem.

You have to start with small dose (200mg daily) and increase gradually.





Or, did you split it into half and just take one of the halves for the whole day?





This.
Increase dose gradually, you have to regulate depending on your physical answer.

james1947

dioporcolorisolvo
As I am encountering also some Pentox side effects, I will also appreciate your answer to MattF
Quotedioporcolorisolvo, did you cut the 400mg tablet in half and then further split the tablet into 1/3's and take a third every 8 hours? Or, did you split it into half and just take one of the halves for the whole day?
Thanks
James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

MattF

Quote from: dioporcolorisolvo on March 05, 2012, 01:03:15 PM
Quote from: MattF on March 05, 2012, 12:55:34 PM
Quote from: dioporcolorisolvo on March 05, 2012, 11:26:26 AM
Quote from: MattF on March 04, 2012, 10:10:32 PM
I don't know if this has been discussed before so please forgive this newbie if it has.

The only side effect that I have with Pentox is that it acts as a powerful diuretic. I see why some bodybuilders take Pentox before a contest to get that cut-look.

The first dose I took was right before bed and within 10 hours, I urinated one gallon!! Yes, I keep a measuring jug by the side of my bed for a previous bladder issue I had and I used it to test what was happening to me with the Pentox.

I urinated so much that I became dangerously dehydrated. I had sharp pains in my side that had not happened since I was 7 years old when I was hospitalized for dehydration. This time I just kept drinking till the pain stopped, and thank God it did.

But that leaves this problem. I can't be running to the bathroom every 15 minutes when on Pentox.

I'm just wondering if anyone else has had this side effect and if so, does it go away, or is this something that I'm stuck with until hopefully this 90 degree bend in my penis goes away?

Please share your thoughts. Thank you.

I have had the same problem.

You have to start with small dose (200mg daily) and increase gradually.





Or, did you split it into half and just take one of the halves for the whole day?





This.
Increase dose gradually, you have to regulate depending on your physical answer.


dioporcolorisolvo, thanks again. I know our bodies are different but can you give me an idea how you increased the dose, how fast, and how much? It looks like your answer can also help james1947. Any additional thoughts would be great. Thank you.

dioporcolorisolvo

Quote from: MattF on March 05, 2012, 03:29:40 PM
Quote from: dioporcolorisolvo on March 05, 2012, 01:03:15 PM
Quote from: MattF on March 05, 2012, 12:55:34 PM
Quote from: dioporcolorisolvo on March 05, 2012, 11:26:26 AM
Quote from: MattF on March 04, 2012, 10:10:32 PM
I don't know if this has been discussed before so please forgive this newbie if it has.

The only side effect that I have with Pentox is that it acts as a powerful diuretic. I see why some bodybuilders take Pentox before a contest to get that cut-look.

The first dose I took was right before bed and within 10 hours, I urinated one gallon!! Yes, I keep a measuring jug by the side of my bed for a previous bladder issue I had and I used it to test what was happening to me with the Pentox.

I urinated so much that I became dangerously dehydrated. I had sharp pains in my side that had not happened since I was 7 years old when I was hospitalized for dehydration. This time I just kept drinking till the pain stopped, and thank God it did.

But that leaves this problem. I can't be running to the bathroom every 15 minutes when on Pentox.

I'm just wondering if anyone else has had this side effect and if so, does it go away, or is this something that I'm stuck with until hopefully this 90 degree bend in my penis goes away?

Please share your thoughts. Thank you.

I have had the same problem.

You have to start with small dose (200mg daily) and increase gradually.





Or, did you split it into half and just take one of the halves for the whole day?





This.
Increase dose gradually, you have to regulate depending on your physical answer.


dioporcolorisolvo, thanks again. I know our bodies are different but can you give me an idea how you increased the dose, how fast, and how much? It looks like your answer can also help james1947. Any additional thoughts would be great. Thank you.

Probably you will have to do various attempts, like me.
It's useless to say to you how to increase dose...it depends from your physical answer.
You can try to take 200mg for 7 days, 200mg x 2 for 7 day, 200mg x 3 for 7 days, 200mg x 4 for some months and then increase.
If the problem goes on stop it and retry from beginning scale after some week.

MattF

Quote from: dioporcolorisolvo on March 05, 2012, 04:10:47 PM
Quote from: MattF on March 05, 2012, 03:29:40 PM
Quote from: dioporcolorisolvo on March 05, 2012, 01:03:15 PM
Quote from: MattF on March 05, 2012, 12:55:34 PM
Quote from: dioporcolorisolvo on March 05, 2012, 11:26:26 AM
Quote from: MattF on March 04, 2012, 10:10:32 PM
I don't know if this has been discussed before so please forgive this newbie if it has.

The only side effect that I have with Pentox is that it acts as a powerful diuretic. I see why some bodybuilders take Pentox before a contest to get that cut-look.

The first dose I took was right before bed and within 10 hours, I urinated one gallon!! Yes, I keep a measuring jug by the side of my bed for a previous bladder issue I had and I used it to test what was happening to me with the Pentox.

I urinated so much that I became dangerously dehydrated. I had sharp pains in my side that had not happened since I was 7 years old when I was hospitalized for dehydration. This time I just kept drinking till the pain stopped, and thank God it did.

But that leaves this problem. I can't be running to the bathroom every 15 minutes when on Pentox.

I'm just wondering if anyone else has had this side effect and if so, does it go away, or is this something that I'm stuck with until hopefully this 90 degree bend in my penis goes away?

Please share your thoughts. Thank you.

I have had the same problem.

You have to start with small dose (200mg daily) and increase gradually.





Or, did you split it into half and just take one of the halves for the whole day?





This.
Increase dose gradually, you have to regulate depending on your physical answer.


dioporcolorisolvo, thanks again. I know our bodies are different but can you give me an idea how you increased the dose, how fast, and how much? It looks like your answer can also help james1947. Any additional thoughts would be great. Thank you.

Probably you will have to do various attempts, like me.
It's useless to say to you how to increase dose...it depends from your physical answer.
You can try to take 200mg for 7 days, 200mg x 2 for 7 day, 200mg x 3 for 7 days, 200mg x 4 for some months and then increase.
If the problem goes on stop it and retry from beginning scale after some week.


That sounds great. I'll give it a try. Thanks very much. :)

james1947

Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

George999

Guys, please try to refrain from nesting all of those quotes because it just clogs up the thread and makes it less readable.  It also takes just that much more space on the server which will eventually end up costing somebody money.  The best rule of thumb is to avoid quotes when possible.  When necessary, just quote that part which is immediately relevant to your comment.

Frequent urination is often associated with anxiety, and I believe anxiety has been mentioned multiple times on this forum as being a potential side effect of Pentoxifylline.  It often happens as a result of an adrenal imbalance when Cortisol somehow overpowers DHEA.  So if DHEA production becomes suppressed or if excessive DHEA is removed from the bloodstream, this can happen.  Just one of the triggers that can cause this to happen is an increase in Insulin which can be a result of an increase in blood sugar or some other cause.  All of these hormonal systems in the body are intricately connected and can be easily disrupted.  - George

Old Man

Note to all:

In addition to the suggestion by George999 below , you can simply just list the post number in the thread so that anyone can refer back to the entire text.

As he said, the extraneous material simply reduces the size of our memory on the forum and eventually it will cost extra to the administrator.

Old Man
Age 92. Peyronies Disease at age 24, Peyronies Disease after
stage four radical prostatectomy in 1995, Heart surgery 2004 with three bypasses/three stents.
Three more stents in 2016. Hiatal hernia surgery 2017 with 1/3 stomach reduction. Many other surgeries too.

dioporcolorisolvo

Quote from: George999 on March 06, 2012, 10:49:31 AM

Frequent urination is often associated with anxiety

If you take pentox and you urinate every 30 minute the double of normal amount......anxiety has nothing to do with this problem.
It's just a collateral effect of the drug.

MattF

Quote from: George999 on March 06, 2012, 10:49:31 AM
Frequent urination is often associated with anxiety, and I believe anxiety has been mentioned multiple times on this forum as being a potential side effect of Pentoxifylline.  It often happens as a result of an adrenal imbalance when Cortisol somehow overpowers DHEA.  So if DHEA production becomes suppressed or if excessive DHEA is removed from the bloodstream, this can happen.  Just one of the triggers that can cause this to happen is an increase in Insulin which can be a result of an increase in blood sugar or some other cause.  All of these hormonal systems in the body are intricately connected and can be easily disrupted.  - George

I don't know about the anxiety aspect because I didn't feel anxious when taking my first dose of 400mg. Also, my sugar levels are definitely low on purpose. And since I was sleeping, I don't know if the cortisol levels would have been higher than normal. But, since bodybuilders use Pentox as a diuretic, it clearly had that effect on me. Certainly, Pentox increases blood-flow throughout various aspects of the body and in doing so, can cause the body to lose water.

I'm going to take dioporcolorisolvo's suggestion and reduce the dose. I'll start again on Saturday just in case I start going into a "urinary frenzy". I don't want to be working or sleeping should that happen.  :)

Lastly, I'm sure you guys are aware since you've been tackling this issue long before me, that Pentox is as close to a miracle drug as is possible. Very few side effects yet has enormous potential to help various maladies associated with circulation issues. Anything that pumps more blood into the smallest blood vessels is normally a good thing for the human body.

Also, sorry about the excessive quoting.  

james1947

MattF
Not related to the race horse urinating.
Even that I am using Pentox just for 7 weeks I have to agree with you that Pentox is close to a miracle drug. It helps me on other issues also, not just Peyronie's.
James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

neptune

Thanks for the info. I think my body has adjusted, and sometimes I take just one instead of two at a time, or will skip a dose here and there, in still trying to keep it in general in my system. If I don't take on a full stomach or with yogurt/kefir however, I still feel pretty awful. I don't have a ton of body weight so I'm sort of monitoring on my own.

Dr. Lue is actually my doctor and suggested we try this as he's had some recent success, but to take it back down to one 3xday if it feels like it's too much. I'm starting to think that it could suffice due to not having a lot of body weight, but I'm still on the side of experiencing minor discomfort now for the long run. If the symptoms return however, I am not going to continue the 6xday. My body and everything I read seems to think it's a bit much.

swolf

Hi - This is my first post on the forum and I will probably go back to introduce myself and my specific case later, but I wanted to ask some questions that I don't want to wait on. They pertain to anxiety side effects from taking Pentox. Sorry for the length and the amount of info, but I have found I glean many tidbits of info when people post long messages, so I think more info/experiences logged on the record are always a good thing.

I have what I would term as low-level transient anxiety, most often just a slight feeling of unease or worry, oftentimes fading to feeling pretty 'normal,' but I am also prone to breakouts of *severe* anxiety under times of abnormal stress. Due to circumstances in my life I'm not sure I will always be able to avoid this stress. I have found these times of severe anxiety to DIRECTLY influence my Peyronie's, to the extent that I believe it to be the driving cause of the continued development of it for me. Keeping anxiety under control is my number one priority in dealing with Peyronie's, and also my number one stumbling block. So that's where I'm coming from.

I have a very good relationship with an acupuncturist who has helped me with my Peyronie's, but at this point he's targeting the anxiety as we both agree it is a huge driving factor. I can't afford to go to him often anymore, but I try to when I can, and I get a round of herbs that never lasts as long as I wish it would, because they do help in a gentle, rounded way. I take Acetyl L-Carnitine and CoQ10 religiously (I am 28 y/o).

I have close to a year's supply of Pentox on hand and recently took 400mg 3x daily for about a month and what I experienced was close to amazing. I don't know if there were any concrete improvements in the structure of my penis, but the reduction in pain, the increased bloodflow and fuller flaccid state, and harder erections were very promising. I don't have significant curvature when erect (I do sometimes when not erect), but I do have scars, plagues, dents, hinging(?), distal tapering when not fully erect, etc, I don't even know what all... straight but damaged-looking, with loss of girth. The problem was after about a month into it I felt it was getting to be too much, I was getting irritable and had too much energy, and then WHAM, I ran into some life events that threw me into a terrible state of anxiety, the worst part lasting about a week or two, trailing off for a few weeks after that. I stopped Pentox pretty quickly, though I stupidly took it for days longer than I should have. I feel it really was changing the chemistry of my brain or something. It was during this time that all my symptoms came back and went on to get much worse. One day I checked my penis and it was scarily, impossibly thin-looking. I developed a few new scars (or whatever they are - actually I think these were already there in minor, latent form) and some I had got bigger, a dent on my right side also increased, and I think I lost some more girth. These are all apparent when erect. The worst of this healed a little in the weeks afterward, but I am still left significantly worse off than I was before. The irony is not lost on me -- what I believe to be the only answer ultimately had a hand in worsening my symptoms.

It was during this time I tried many supplements for anxiety in a struggle to get it under control. Stabilium worked (and still does, I'm taking it sporadically now) very well for me, as did a supp by Source Naturals called Theanine Serene, as did acupuncture a few weeks afterwards, as well as just letting everything run it's course and leave my body. I also took/take fish oil, aloe vera, bioactive milk peptides, valerian (this I've always had on hand, recently got the Valerian Nighttime kind but haven't used it much), maybe a few other things. I'm going to get a full food allergy test and a vitamin D test done in April.

I feel being able to get back on Pentox is the *only* way I will beat this, but I am extremely hesitant to at the moment. My questions revolve around the "timeline" of the interrelation between Pentox and anxiety: Has anyone that has anxiety problems and takes Pentox noticed if these side effects are a constant after a month into it, or do they come on and then settle down? Is anxiety something you struggle with constantly while taking Pentox? What have you done to get into a groove where you are able to take the medication and function? This is mostly directly to anyone out there that is prone to severe anxiety. Have you found a way to make Pentox work for you? I realize this has been talked about on the boards before and I'm reading everything I can find, but I'm really wondering about people's experiences with the long-term handling of anxiety on Pentox. I would like to get back on 400mg 2x a day, cut out all sugars (ate no added sugars for two years once, so I have experience with that), try to get more exercise...

At one acupuncture session, when I think the acupuncturist felt I was leaning too much on him like a therapist or something, he calmly but bluntly told me "your only option is to become a wise man." Which I took to mean ultimately each person is an individual and must figure out what works best for them, and that wisdom can only come from within. Ain't easy, though.

cowboyfood

swolf,

Good questions.  I noticed that while I was on Pentox I experienced episodes of anxiety.  I took Pentox for 2 and 1/2 years and I believe it helped my condition.

When I stopped Pentox usage, I noticed that I did not have these episodes of anxiety.

Prior to taking Pentox, I cannot recall ever experiencing the anxiety-type feelings I had while on Pentox.  However, I was aware that this is a side-effect for some, and I rationalized that it was probably the medicine.  So, I could generally keep the anxiety in some perspective.

I wish I could provide you more detail other than these generalizations,  but based on my experience, I believe I experienced some anxiety caused by Pentox, but I'm not sure.

CF
Currently:  L-Arginine (2g), Vit D3)

PablitoNJ

I looked on drugs.com for Pentox side effects -

Pentoxifylline has been marketed in Europe and elsewhere since 1972. In addition to the above symptoms, the following have been reported spontaneously since marketing or occurred in other clinical trials with an incidence of less than 1%; the causal relationship was uncertain:
 
Nervous - anxiety, confusion, depression, seizures, aseptic meningitis.

I guess the question comes down to a benefit analysis. Does Pentox provide enough benefit to your Peyronies Disease so it outweighs the potential anxiety that can occur by taking it? Perhaps knowing that Pentox is a cause of anxiety, can that knowledge help you to control the anxiety? That is - I know that taking this is going to cause anxiety, but I can deal with it because I know that it is a benefit to my Peyronies Disease.