PENTOX effect on Peyronie’s

Previous topic - Next topic

0 Members and 1 Guest are viewing this topic.

George999

As noted by other posters the protocol for Pentoxifylline is 400mg 3X per day (usually 1 pill with each of three meals).  A major study has found 400mg 2X per day to be effective.  The documentation supporting the use of Pentoxifylline for the treatment of Peyronie's is not a lot but it is there:

https://www.peyroniesforum.net/index.php/topic,772.0.html
https://www.peyroniesforum.net/index.php/topic,1004.0.html
https://www.peyroniesforum.net/index.php/topic,2070.0.html
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163605/

james1947

Thank you for your inputs.
I will begin with one daily because I have many allergies and I don't know how my body will react to Pentox.
If OK, I will begin 2 daily. The prescription I can use many times to get the Pentox. They cal the tablets "Trental 400mg" and not Pentox or Pentoxifylline. It is the same drug? The uro says yes.
George
I have downloaded/copy all the references will read and give to the uro also, thanks.
James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

dioporcolorisolvo


LauRenT

The most important thing is to take them separately in the middle of the three meals. I feel a little lucky maybe but in my case, 3 month on pentox ( always in 3x400mg dose ) and really no bad effects.

james1947

dioporcolorisolvo
Thank you for the input, I wanted to be shore is not something else.
LauRenT
* You have recorded some improvement in 3 months?
* What you men in the middle of the three meals? During the meals or in the time between one meal and the next one?
James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

dioporcolorisolvo

Quote from: james1947 on January 12, 2012, 08:37:23 AM
dioporcolorisolvo
Thank you for the input, I wanted to be shore is not something else.
LauRenT
* You have recorded some improvement in 3 months?
* What you men in the middle of the three meals? During the meals or in the time between one meal and the next one?
James

You can assume pentox 1 hour after the meal. I did in this way.

George999

I ALWAYS take Pentox WITH the food.  It could be IMMEDIATELY before or DURING or IMMEDIATELY after.  But it needs to be at the same time you are eating in order to avoid gastro intestinal problems.  And by all means try to avoid taking it anytime close to bed time.  I take mine around 9:00AM, NOON, and 5:30PM.  - George

dioporcolorisolvo

I think that everyone has different ways.
If i had pentox during or immediately after i had gastrointestinal bad effects.
So i took it 1 hour after meal.
Everyone has to find his own solution.

LauRenT

James

I'm nearly in my third month with pentox, taking during the meal in my 3 meals.
I also take Vit D3, K2, Ubiquinol, since 2 weeks.
L-arginine, pycnogenol since 1 month.
ALC, PLC, Gamma tocopherol + tocotrienols since 3 months.

I m on the VED s protocole, in my 4th week.

Now i can see some improvement, even it's really not the end of the battle. All of this plan with a healthy food, something good happen. Hope it will continue.

Laurent

newguy

LauRenT - I'm glad you feel that you're on the right track. It's all about sticking with it for the longhaul, and not stopping treatments due to becoming dispirited.

LauRenT

 Thanks newguy, i waited 9 month to start something ( just following the clever advices of Uro, wait and see and synthetic Vit E), saw the results....
So being active and constant, that s the only things we can do, no choice.

About treatment, in my case pentox, ALC/PLC are on the top of the list with VED for now. For D3/K2, Ubiquinol, too early to say.
I don't ask a F..... miracle, just a response of my action against that situation.

Noway

I can honestly say that pentox and cialis together I see the most positive results its just expensive expecially when you pay for both of them.  

james1947

Yesterday I take my first 400mg Pentox during breakfast. No any side effects!!! Hope will continue like that, after one week I will increase to two daily.
I have one question:
I am tacking 100mg Aspirin daily as blood thinner and my Uro told me not to take it if I am on Pentox because Pentox can cause internal bleeding.
I am concerned not taking the 100mg Aspirin as my blood counts are all high, so the blood have more tendency for clothing.
Any advice?
James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

George999

Quote from: james1947 on January 15, 2012, 06:00:01 PM
Yesterday I take my first 400mg Pentox during breakfast. No any side effects!!! Hope will continue like that, after one week I will increase to two daily.
I have one question:
I am tacking 100mg Aspirin daily as blood thinner and my Uro told me not to take it if I am on Pentox because Pentox can cause internal bleeding.
I am concerned not taking the 100mg Aspirin as my blood counts are all high, so the blood have more tendency for clothing.
Any advice?
James

I would be VERY careful combining multiple blood thinners.  Ordinarily I would not be particularly worried about combining Pentox with Aspirin, BUT ONLY your personal physicians know your individual situation.  IF your blood chemistry is abnormal in ANY way, you MUST coordinate your drugs with a qualified medical professional.  There are no other options.  If you are unable to get the care you need in this regard, I would urge you to look for a Functional Medicine specialist who can help you to resolve your medical issues without endangering your life.  - George

james1947

George
Thank you for the advise.
I have no a haematolog in my are. I have stopped the Aspirin, even that is a very small dose.
The only other blood thinner I am taking is bear. I don't stop it  ;D
James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

Noway

james1947 you wont notice any side effects if you take pentox once for one day and one pill. Also why exactly do you take aspirin?

james1947

Noway
I am taking 100mg aspirin from 1995 when I had a hearth attack (and balloon for one of my veins)as blood thinner. I have also a blood disorder that make my trombocyte (platelets) high and aspirin prevents clothing.
Regarding Pentox, I began one daily because I have allergic reaction to some mastication's and foods. If will continue with no side effects for one week, I will increase to 2 daily.

Somebody know if Pentox is considered a blood thinner also?
James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

GS

I'm almost positive it is considered at least a mild blood thinner.  I take 2 a day and I also take a low dose aspirin, but I have never had any problems with bleeding.

GS

james1947

GS
Thanks for the information. I will begin today to take again the 100mg aspirin 12 hours after the Pentox. When will begin with 2 daily Pentox at 12 hour apart, I will take the aspirin at 6 hours from both Pentox.
James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

George999

They are blood thinners by two different routes.  Aspirin attacks platelets and pentoxifylline causes red blood cells to be more flexible and thus able to flow more easily through small openings.  - George

james1947

George999
Thank you for the information.
My red blood cells count are at 9.4 because of many phlebotomy's to reduce from 19.8
Platelets were on the 750,000 and gone up (during 2 year period) because the phlebotomy's I think to 1,200,000. Two months no phlebotomy's and is down to 980,000. Hope will continue to go down.
The white blood cells are in the 22,000. I read on the forum that Pentox reduces very much white blood cells count. Hope it will do it for me also.
James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

james1947

Just a small Pentox update:
After one week of one daily Pentox I am 5 dais with two daily. I am taking them morning and evening during my meals and for my surprise have no any side effects. I am taking the 100mg aspirin at noon and also no any problems.
James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

james1947

One month on Pentox, 2*400mg daily.
Peyronie's benefits:
- Flacid stated more full. Before Pentox in flaccid state was shrinking almost all in my body, not anymore.
- More easy to be aroused, some partially erections not just from physical stimulation. Just from watching my wife with sexy dress or touching her accidentally. I had no such thing from the start of my Peyronie's.
- For the first time in long period I was able to get a good erection that lasted enough long for my wife to have a full satisfactory orgasm without
the 50mg or 100mg Viagra
Other benefits:
- I had many cramps in the legs and feet specially when laying down or riding my motorbike. They completely stopped.
- I had many small blue veins on my face and my feet, most disappeared.

So for me even just one month Pentox improved my situation a lot. Maybe some phsycological effect also? I don't know.
(The speller says phsycological is wrong but don't give a good alternative, hope the people understand what I mean)
James  
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

james1947

dioporcolorisolvo
We are almost three months after you have started this topic.
Are you continuing with Pentox?
If yes, how is your progress, positive or still negative?
James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

dioporcolorisolvo

Quote from: james1947 on March 22, 2012, 08:49:46 PM
dioporcolorisolvo
We are almost three months after you have started this topic.
Are you continuing with Pentox?
If yes, how is your progress, positive or still negative?
James

I'm not taking pentox.....also if i haven't understund reason, pentox worsened situation, as infiltrations, traction and ved.
I'm taking ALC and ubiquinol. I've erections very very strong, but until now i've noticed a small improvment on peyronie's symptoms (deformation, curvature) only when i eliminate all sugars and refined carbo from diet. This is not simple, but it's obligatory for me.
I think the only possibility to improve is to eat only fruit, A LOT OF vegetables, meat and fish. Stop.
Whitout sugars i feel more depressed, especially without chocolate, but the only road to do is that.

james1947

dioporcolorisolvo
Thank you for your prompt answer.
It seems that sugars are the main issue, not just for Peyronie's. I am reading (and trying to learn) regarding blood sugar, George have some deep professional posts in the subject.
If you didn't read them yet, I am proposing you to do that.
James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

dioporcolorisolvo

Quote from: james1947 on March 23, 2012, 09:26:53 AM
dioporcolorisolvo
Thank you for your prompt answer.
It seems that sugars are the main issue, not just for Peyronie's. I am reading (and trying to learn) regarding blood sugar, George have some deep professional posts in the subject.
If you didn't read them yet, I am proposing you to do that.
James

Also i've studied the argument of food...i follow paleodieta.

IHP

I found a video interview with Dr. Lue, and he mentions that Collagen injections might soften the scar tissue too much and leave the tunica thin and weak, which would make it more prone to fracture. Could this also apply to Pentox?

Skip to 3:30 in the video.

oncologytube.com/index.php?page=videos§ion=view&vid_id=100494

james1947

IHatePeyronies

Personally, I don't think so. Pentox is softening the scar tissues very slowly.
I think I have read almost everything on the forum regarding Pentox and don't read any post that the tunica albuginea became weak.
Many people that thy scar tissue was softened reported strong erections that I think is impossible if the tunica albuginea is weak.

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

IHP

Hmmmm....but the scar tissue is not being replaced by healthy tissue. Wouldn't that leave you in a weaker state?

james1947

In my opinion, softened scar tissues are also fuller and healthier than the not softened scar tissues and they don't need to be repaced.
You can read many testimonies on the forum, especially on the improvements and the oral treatments board.

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

Plowshare

I'm a 28yo single man who hasn't masturbated for a little over five months now. I haven't experienced many good erections, but this morning I experienced a very good one. I decided to take advantage of the event to thoroughly examine myself (I've experienced ED in the past and wanted to get some answers). The most physically stressful thing I did during the self examination was to lie on my back (supine) and to elevate my penis 90 degrees to be roughly perpendicular with my body. I also stroked my penis a few times by moving the foreskin back and forth over the tunica (probably a total of 10 or 15 times total) during the self exam (with no lubricant), but I was very gentle and quite slow in the stokes. I didn't rhythmically masturbate or stimulate myself to he point of ejaculation.

Anyway, after it was all said and done and my erection subsided, I felt some pain at the very base of my penis like I was being pinched (this was on the right side). A few minutes later, while flaccid, I felt a sharp shooting pain mid shaft on the right side (this is where most of my peyronie's scars are). This is the second time I've felt this shooting pain in the last few days. The first time I felt it I was totally flaccid and was doing a sort of yoga style stretch to stretch out my back. (I was lying prone, pelvis to the ground and elevating my back off the ground with my arms, and looking up to the sky with my face. I did this to stretch out my back after a work out.)

I'm wondering if I should try to get a script written out today for Pentox as a precautionary measure? I have benadryl on hand. Should I use that as an anti-inflammatory drug/ precaution in the mean time?

Plow

james1947

I am a big fun of Pentox because it helps many on this forum and I would say yes, start Pentox, it may reduce pain and many other benefits regarding Peyronie's.
In my opinion you have to see an uro and to begin treatment, not only Pentox.

Regarding benadryl, I know that is an antihistamine, I don't know how it should help with your pain.

James

Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

corvette2010

I'm also 28. Have had peyronie's for a couple years or so now and have had pain in the left side where my scarring is. My bend wasn't ever that bad, only slightly to the left (i'd say 5 or so degrees) I have been on pentox (2 a day, can't tolerate 3) since January and *knock on wood* most of my pain is gone and i'm pretty much straight now, bend isn't noticeable at all. i'll probably continue my pentox thru my prescription (probably get me through the year) And hope that with a decent sex life, exercising regularly and a postive attitude that it will stay this way!


And yes the moral of the story and try pentox and see if it helps you!

charlie44

Been on it for 9 months now. Have no idea if it has done any good...disease has progressed some in that time. Has Pentox negated worse results?...who knows?

How long have people been on it, and per your experience did it help, and if so, how long did it take to have a positive effect?

George999

I was on it continuously for close to four years, starting in June of 2008.  I still have it on hand in case I need it.  Pentoxifylline and Ubiquinol have been the two best oral treatments for Peyronies that I have found.  Pentox stopped most of my pain within days.  Later on a combination of Pentox and Ubiquinol stopped ALL of my pain.  Over time (years) on Pentox, I saw my level of deformity improve to the point of not being an issue.  Fortunately, due much to the fact that I was attacking Peyronie's to the best of my ability from the beginning (2004), my deformity never became severe.  I am now getting by on 100mg Ubiquinol 3X per day AND controlling my blood sugar levels rigorously.  - George  

james1947

I have posted at:
Peyronies Society Forums > Peyronies Disease TREATMENT Discussion Boards > Oral Treatments for Peyronie's Disease (Moderator: james1947) > PENTOX effect on Peyronie's
At March 27, 2012, 10:07:20 PM a Word file attachment on a small search regarding your question.
You can download and read it.

You can also check out in "Oral Treatments for Peyronie's Disease" the topics:
PENTOX - periodical updates and observations « 1 2 »
PENTOX - Questions « 1 2 3 4 »
PENTOX (where to get it and does it work?) - My Experience « 1 2 3 4 5 »

By reading the above you will get full answer to your questions.

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

Noway

pentox takes about 5 months to start noticeing huge results and it does work. It works better with cialis. I would consider pentox and cialis at any cost.

Iceman

ive been 5 years on pentox and I have seen absolutely no improvement - yes erections are stronger but the curve is there and i would say may have gotten worse over the yrs to say 35-40 degrees - i reckon that the ved has made it slightly worse

When the F**K is xiaflex happening - ??

james1947

Iceman

Sorry to hear about your results with Pentox and VED.
My experience with both is very good. Pentox and VED are helping me getting a better erection (not using VED for intercourse, just as treatment).
Regarding Xiaflex, remember that people that have calcified plaque were excluded from the trial!!! Easy to guess why.
Hope your plaque/plaques are not calcified and with Xiaflex treatment you will be in the 18% that improved more than the placebo guys. :)
18% more chance for improvement with Xiaflex compared with no Xiaflex.

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

egghead

Iceman- How much are you taking per day?  

George999

I think in some cases Peyronie's can become really aggressive and no amount of treatment can stop it.  Iceman, you are not alone, there are other guys here who are feeling similar frustration.  You can only do what you can do.  You may, indeed, have suffered regression in spite of everything, but things likely would have been much worse with no treatment at all.  I would encourage you to openly discuss Xiaflex with your physicians if you have not already done so.  It is NOT going to come to you.  You have to be your own advocate and pry open the doors.  That often takes phone calls and emails to specialists in far away places.  Have patience and one day you will conquer this.  I wish you all the best.  - George

Iceman

thx guys...

1) i would say my plaques are calcified, so that being the case is there any point me taking pentox?
2) how would i go about getting xiaflex in Australia?? - does anyone know of a uro that treat Peyronies Disease with xiaflex? - i have only been to a uro once in the 5 yrs that i have had this and have got all my information from this site. I went to dr malouf in st george hosp originally in Sydney and he was the guy who told me about pentox - I actuall then flew to SF to meet with Lue and all i got was pentox from him as well....so after 5 years is there anything else that i can do/take - oh...i also take coq10 and Larginine, but thats about it....
3) I am taking 1 x 400 mg per day of pentox - thats all...

any help would be much appreciated

RichP

hi,

regarding pentox and calcifications..

Pentoxifylline treatment and penile calcifica... [Asian J Androl. 2011] - PubMed - NCBI. i have been taking pentox for 2 years now and am also wondering when to stop with it.

As far as getting xiaflex in AU your best bet would be to research who the local peyronie's 'expert' is closest to you and to have a phone chat with them. It's not available in the UK yet, however.

gl, rich

james1947

In my opinion 3*400mg Pentox per day is a minimum for expecting some results.
Some leading Peyronies expert are giving double of that.
I run out of the supplements and I try to find a source that will ship with Parcel Post as UPS/FedEx/DHL are charging here locally $50 in addition to what I pay for the shipment.
Now on Pentox and low dose Cialis only and no regression, some slight improvement.
VED has given me back 1/2" from 2&1/2" I have lost to Peyronies so now at little bit more than 5", 1/2" is 10%. Get back some girth also and the deformities are a bit better. The change is constant as I am not doing VED in the last three months because of no privacy at the moment with 14 years old son and 3&1/2 year old daughter in a small house and have no regression.
I am not a big fun of Xiaflex, as I have written calcified plaques where excluded from the trial and mine are calcified :(

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

Iceman

if you are doing 3 x 400 per day and you see no improvement- do you think that i should increase my dosage? - i mean, what's the point?

james1947

I would not advice 6*400mg Pentox a day if not under doctor supervision.
I think taking 3*400mg per day fro a long period it may help some (and some not, like everything with Peyronies :()
One of Pentox side effects can be internal bleeding that is a very serious issue!!!

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

George999

One thing you might try for calcifications is Vitamin K-2.  Vitamin K-2 is crucial in moving calcium from soft tissue into the bones where it belongs.  It is relatively inexpensive.  If I were in your shoes, I would give it a shot.  - George

Iceman

george  - how do i know if im calcified or not? also if i am not calcified would it be worth trying the K2?  - i have not heard this mentioed before....I mean does this help with Peyronies Disease - one thing to note I have stopped ALC - could this be a factor in things not improving??

many thanks

RoyHobbs

Iceman-

You'll need a uro to do an ultrasound in order to determine whether your plaques are calcified. It's a good idea to get one anyway.