TRANSDERMAL VERAPIMIL - Efficiency & Questions

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funnyfarm

Thanks so much an please keep us updated with your progress.  I have read the gel can actually cause some pain early on as it is softens the tissue. But I hope longer term it brings relief to your symptoms.
When you are in tune with the unknown, the known is peaceful.

james1947

cs65

I will advice you to start with oral treatment and especially Pentox. Almost everyone had pain releave with Pentox.

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

cs65

Thanks James.  I've been on Pentox for 2 years now.  400mg 3x per day.  No improvement in pain or scarring.

james1947

cs65

Sorry to hear that Pentox don't helping you with the pain. I don't know as I never had pain and just recently increased to 3*400mg daily.
I have small improvements with my Peyronies but I really don't know what is helping because I am on a combination of VED, Pentox and supplements.
Like everything with this disease, what is working for one, doesn't mean it will work for the other :(

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

MattFoley

Quote from: cs65 on December 09, 2012, 08:12:39 AM
Thanks James.  I've been on Pentox for 2 years now.  400mg 3x per day.  No improvement in pain or scarring.

cs65,

Please consider talking to your Urologist about doubling the dosage. I've seen that recommended by Dr. Lue for another patient.
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MattFoley

I guess this is the best place to ask this so, has anyone tried the following:

Verapamil hydrochloride 15% gel,
Trifluoperazine, and
magnesium sulfate, all incorporated in a transdermal vehicle?

According to this study http://www.ncbi.nlm.nih.gov/pubmed/17367443, here are the results:

RESULTS:

Fifty-seven patients were randomized. In total, 94.4% of patients treated for 9 months with topical verapamil experienced improvement in curvature with an average percent curvature change of 61.1% compared with 43.6% curvature improvement at 3 months. At 9 months the average percent plaque change was 84.7% compared with 55% at 3 months. Pain resolution at 9 months was 100% compared with 87.5% at 3 months. Patient perception of erection quality also increased at 9 months to 81.8% compared with 72.7% at 3 months.

CONCLUSIONS:

Topical verapamil gel proved effective in eliminating pain on erection, decreasing the size of plaque, decreasing curvature, and improving erection quality in patients with Peyronie's Disease. Treatment results improved significantly after 9 months' treatment as compared with 3 months' treatment.


Anyone?
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james1947

To good to be true.
The results are like silver bullet for Peyronies 8)
Almost 6 years from the publishing time it should be by now be the mainstream treatment for Peyronies.
Maybe I am wrong and have no reason why the leading urologists don't support that.
Xiaflex seems also much less effective.

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

MattFoley

Thank you, James, I'm having a hard time trying to get any info on this. The results of that study are nothing short of amazing yet no one is talking about it. I guess long-term treatment and surgery just brings more money in for the doctors. Perhaps the answer goes back to money again. I don't know what is going on but I aim to find out.

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james1947

Matt

You are right regarding money. It not supposed to be the main drive for a doctor, unfortunately, not like in the old times when I was kid it is today for many. :( It is natural in our materialistic world. :(
It is an interesting subject, hope in some two weeks I will have Internet again at home (from a bar now) and I will go true all the posts to collect the information (positive or negative) regarding topical Verapamil.

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

BrooksBro

Even if it is not commercially available, if you can get a doctor to write the prescription with the exact percentage of ingredients, there are compounding pharmacies which can make it.  

This past year I used a prescription lotion made from five different pain medicines.  This was mixed by a compounding pharmacy and supplied in four 480 gm tubes.  Fortunately, the cost was mostly covered by my private insurance.  My out-of-pocket was $200 US.  The total medication cost was about $18 US per gram.  Dose was 1/2-2 grams four times per day.

MattFoley

I would be happy to talk to my doctor and a compounding pharmacy about this but I have no idea what the chemical mix is as per the article in question. If anyone knows, please share. Thank you.



Quote of the Day:

Don't forget, Jesus loves you but He loves me more. :)
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Knight

Just to weigh in on this subject - I have been using transdermal verapamil for about 4 months now and have noticed minimal to zero results. It's a pain in the rear to apply twice everyday and it does cause irritation. I've threatened myself to quit renewing the prescription but continue to trudge forward in the hope that it might magically start working. I have my doubts.

I did call and talk to the pharmacist about my concerns when I renewed my prescription and she ran the same "double the dosage by applying 4 times day" as you will read in previous posts on this and other threads. In my case they did not offer to send me additional medication free of charge but offered to contact my doctor to have him double my prescription dose. I politely refused the offer.

I'm thinking this treatment is a waste of time and money. I will update as I proceed and let you know if anything changes for the better or worse.

james1947

Knight
The posts that are saying the trans-dermal Verapamil has helped are very few.
Even in the cases that it "helped", it may be because of the massaging of the place and not the Verapamil.

Matt
Very late answer, almost one year, but your Quote of the day:
QuoteDon't forget, Jesus loves you but He loves me more. :)
Is completely WRONG.
HE loves all of us the same, including the bad between us  :)

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

MattFoley

James, thank you for the belated response. :)

Of course. I just like to say that in order to get a reaction from people. I'm always trying to get people to laugh. :)
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james1947

Humor Matt is always good and especially good if you have Peyronies also 8)

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

Pey-penis

I'm new to this forum but have read many articles about. It may be a long message but I have to state some important theorems. First of all is fundamental: there is no the one cause of our problems. Medicine does not know what is the cause of our problems and doctors treat us like in the dark :-) Average urologist doesn't know more than prescribe a pill to You mostly vitamin E. Because disease progresses not only waiting it's waste of time generally I think. One of possible causes is problem with blood circulation other maybe inflammation so there is no one manner for all hence there is a lot of conflicting advices.
I take two of them. "DMSO doesn't work with Verapamil transport to bead under the skin". Who really checked that DMSO is capable to make such transport for Verapamil? :-) I use DMSO and know that it can transport only few known drugs because no one makes such tests because of less profitability. DMSO is cheap and cannot be patented :-( I know that it can transport iodine what I checked by myself (and some chemotherapy ingredients). It is unlikely that it can transport the Verapamil so the results of skin mixture described somewhere here were only from iodine (softening of the lesion) and elimination of inflammation (pain reliever) which DMSO does by itself.
The next one is that Iontophoresis doesn't work. There are some technical details one must to know when he wants to use this technology. First is the polarization of drug used to introduce this way and proper polarity of the electrodes Iontophoresis devices. If the drug has a positive polarity must be placed under the positive electrode device to flow through the body to the negative electrode. Not everyone physiotherapist knows drug polarizations and it and can easily be mistaken.
Apparatus for iontophoresis is simple and easy to make. For whom who want to do i can send a schematic. Photo of my own attached. Sorry I cannot attach.

Freemason

I wouldn't say that DSMO can't transport Veraprimil. it should actually. The new H 100 product currently In trial is using Veraprimil, Possibly DMSO. But likely Emu Oil, and Superoxide Dismutase. I've found the patent for their product and they give exact compounding details to the product for compounding pharmacies. I can provide the link if anyone might be interested. Think I'm going to have a local one where I'm at make it for me. Can't hurt.