Aspirin Found Effective for Erectile Dysfunction

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Paolo

A couple of links on erectile improvement using common aspirin (100mg);

ww.renalandurologynews.com/erectile-dysfunction-Erectile Dysfunction/aspirin-erectile-dysfunction/article/740011/ dead link
https://link.springer.com/article/10.1007%2Fs11255-018-1786-0

I believe it should be taken for a minimum of 6 weeks  :)
Paul.
Whenever you find yourself on the side of the majority, it is time to pause and reflect.

swiss

Makes sense to me. Asprin thins the blood. I heard that ED is effectively the first sign of problems with the heart.  

betterbend

For many people ED is caused by poor circulation into the small blood vessels and capillaries into the penis.  The heart is also fed by small vessels and capillaries, so if you are having problems in one there is a good chance you are having problems in the other.  We obviously notice ED, where we might not notice it in the heart until its too late.  So the lesson is that if there is ED issues without a know reason, you should be checked out by a cardiologist ...  
55 - Onset May 2017.  38 degree bend up.  Failed Xiaflex treatment.  Still functional so I decided to stop treatments.  Only take 400mg Co-Q10 and occasionally use Restorex

Gabriel

Wow very interesting Paolo, thanks for the link!!!
- 35 yo, Peyronies Disease with chronic pain, general hourglassing with girth and length loss since 09/01/17.
- Pain almost cured with Hirudoid cream and diet/lifestyle changes (see my topics on this); deformity still here, but partly reduced with traction + VED.

james1947

I am taking 100 mg aspirin from the age of 48, it means 22 years.
The doctor advised me after having a light hearth attack.
It didn't helped me not to get Peyronies or ED.
But it increases blood flow and helping fight deposits on the veins walls, so is good to take it.
Take it after meal, cam make stomach upset  :)

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

PeetyPeet

Regular use of Aspirin has recently been associated with an increased likelihood of skin cancer in men.

Just mentioning it so people can make an informed decision to use it.

I experimented with aspirin several years ago, it didn't do much for me. As the article suggests, perhaps it only really works for people with high mpv.

The best 'blood thinner' I have ever taken for ed was pentox, the effects of which were significant. Shame you can't get it anymore.  

skunkworks

This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

PeetyPeet

Pentox is a non-selective pde inhibitor so presumably it inhibits pde5 amongst others.

Based on my own experiments with pentox, judging by the effects it had on me, 3 x 400mg a day appeared to be equivalent to maybe 1-2mg of cialis. It also gave me a fuller, softer flaccid, which cialis does not, which lead me to believe that the primary action was its blood thinning properties.

From what I've read ed caused by Peyronies is due to the scar tissue/plaque on the tunica albuginea preventing the TA from expanding sufficiently to close off the outflow veins. I suspect aspirin will have limited affect in these cases.

james1947

Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum

skunkworks

No I guess technically it makes red blood cells more flexible.
This is an emotionally destructive condition, we all have it, let's be nice to each other.

Review of current treatment options by Levine and Sherer]

PeetyPeet

Hmm I could very well be wrong here but my understanding was that pentox reduced blood viscosity (as well as increasing red blood cell deformability) and was therefore a blood thinner in the true sense of the term.

I also was under the impression that the kind of drugs which are often referred to as 'blood thinners' - for example Warfarin - are anticoagulants and don't in truth reduce blood viscosity at all, just reduce clotting.

If I'm wrong I'd welcome correction.....




james1947

QuoteMechanism of Action
Trental (pentoxifylline) is a xanthine derivative. It belongs to a group of vasoactive drugs which improve peripheral blood flow and thus enhance peripheral tissue oxygenation. The mechanism by which Trental achieves this effect has not been determined, but it is likely that the following factors are involved:
Trental, as with other xanthine derivatives, relaxes certain smooth muscles including those of the peripheral vessels, thus causing vasodilatation or preventing spasm. This action, however, may have a limited role in patients with chronic obstructive arterial disease when peripheral vessels are already maximally dilated.
Trental improves flexibility of red blood cells. This increase in the flexibility of red blood cells probably contributes to the improvement of the ability of blood to flow through peripheral vessels (haemorheologic action). This property was seen during in vitro and in vivo experiments with Trental but the correlation between it and the clinical improvement of patients with peripheral vascular diseases has not been determined.
Trental promotes platelet deaggregation.

QuoteImprovement of red blood cell flexibility and platelet deaggregation contribute to the decrease in blood viscosity.
Quote
So it decreases blood viscosity IF platelets count is lowered. If platelets count is not lowered, viscosity not decreased.

QuoteWarfarin inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decreased prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.

QuoteThe analgesic, antipyretic, and anti-inflammatory effects of acetylsalicylic acid are due to actions by both the acetyl and the salicylate portions of the intact molecule as well as by the active salicylate metabolite. Acetylsalicylic acid directly and irreversibly inhibits the activity of both types of cyclooxygenase (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. This makes acetylsalicylic acid different from other NSAIDS (such as diclofenac and ibuprofen) which are reversible inhibitors. Salicylate may competitively inhibit prostaglandin formation. Acetylsalicylic acid's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms; the therapeutic effects are not due to pituitary-adrenal stimulation. The platelet aggregation-inhibiting effect of acetylsalicylic acid specifically involves the compound's ability to act as an acetyl donor to cyclooxygenase; the nonacetylated salicylates have no clinically significant effect on platelet aggregation. Irreversible acetylation renders cyclooxygenase inactive, thereby preventing the formation of the aggregating agent thromboxane A2 in platelets. Since platelets lack the ability to synthesize new proteins, the effects persist for the life of the exposed platelets (7-10 days). Acetylsalicylic acid may also inhibit production of the platelet aggregation inhibitor, prostacyclin (prostaglandin I2), by blood vessel endothelial cells; however, inhibition prostacyclin production is not permanent as endothelial cells can produce more cyclooxygenase to replace the non-functional enzyme.

James
Age 71, Peyronies from Jan 2009 following penis fracture during sex. Severe ED.
Lost 2" length and a lot of girth. Late start, still VED, Cialis & Pentox helped. Prostate surgery 2014.
Got amazing support on the forum